Publications by authors named "Mingyang Zhuo"
Compatible solutes are key for the ability of halophilic bacteria to resist high osmotic stress. They have received wide attention from researchers for their excellent osmotic protection properties. Hydroxyectoine is a particularly important compatible solute, but its production by microbes faces several challenges, including low titer/yield, the presence of the byproduct ectoine, and the requirement of high salinity.
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- Microbial production of N-acetyl-glucosamine is becoming competitive, but glucose consumption limits yield due to competition with central carbon metabolism.
- The study developed a strain (GLALD-7) that effectively utilized glycerol for cell growth while saving glucose for N-acetyl-glucosamine synthesis by optimizing the ratio of glycerol to glucose.
- This strain achieved record production levels of 179.7 g/L N-acetyl-glucosamine in a bioreactor, indicating that managing carbon source utilization can enhance microbial chemical production.