Publications by authors named "Mingyang Wen"
Article Synopsis
- Couples trying to have a baby may feel a lot of stress and worry, which could affect their chances of getting pregnant through treatments like IVF or ICSI.
- In a study, researchers looked at 450 women: 150 who didn’t get pregnant and 300 who did, to see if their stress affected their chances of success.
- They found that the level of psychological distress like anxiety and depression didn’t really change the outcome; both groups had similar chances of becoming pregnant.
Assisted reproductive technology and birth defects in a Chinese birth cohort study.
Lancet Reg Health West Pac
February 2021
Article Synopsis
- The study looked at babies born through assisted reproductive technology (ART) and found they have more birth defects than babies born naturally.
- In China, the research followed nearly 5,000 pregnant women and checked their babies for defects until they were one year old.
- Babies from ART pregnancies had a higher chance of defects at every stage, and certain treatments for getting pregnant also increased this risk.
Emerging evidence suggests that children conceived through assisted reproductive technology (ART) have a higher risk of congenital heart defects (CHDs) even when there is no family history. De novo mutation (DNM) is a well-known cause of sporadic congenital diseases; however, whether ART procedures increase the number of germline DNM (gDNM) has not yet been well studied. Here, we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.
View Article and Find Full Text PDFAim: To develop a prediction model to estimate the chances of live birth over multiple cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment.
Methods: A retrospective cohort study was launched in three reproductive centers including 10 824 couples who received 14 106 treatment cycles with known pregnancy outcomes by the end of 2016. Discrete time logistic regression was used to establish the model and a nomogram was developed to predict the chance of live birth on plain paper-based final predictors.