Development and validation of a Multi-Causal investigation and discovery framework for knowledge harmonization (MINDMerge): A case study with acute kidney injury risk factor discovery using electronic medical records.

Objective: Accurate diagnoses and personalized treatments in medicine rely on identifying causality. However, existing causal discovery algorithms often yield inconsistent results due to distinct learning mechanisms. To address this challenge, we introduce MINDMerge, a multi-causal investigation and discovery framework designed to synthesize causal graphs from various algorithms.

Polydopamine-modified MOF-5-derived carbon as persulfate activator for aniline aerofloat degradation.

Residual flotation chemicals in beneficiation wastewater seriously threaten local ecosystems, such as groundwater or soil, and must be treated effectively. Currently, the degradation of organic pollutants using nitrided MOFs-derived carbon to activate persulfate (PDS) has attracted considerable attention. Hence, we developed a new synthetic strategy to load dopamine hydrochloride (PDA) onto MOF-5-derived porous carbon (PC) to form NPC, and the degradation of a typical flotation Aniline aerofloat (AAF) at high salinity by a low dose of the NPC/PDS system was investigated.

Generation and identification of O in catalysts/peroxymonosulfate systems for water purification.

Catalysts for peroxymonosulfate (PMS) activation are appealing in the purification of organic wastewater. Singlet oxygen (O) is widely recognized as a crucial reactive species for degrading organic contaminants in catalysts/PMS systems due to its adamant resistance to inorganic anions, high selectivity, and broad pH applicability. With the rapid growth of studies on O in catalysts/PMS systems, it becomes necessary to provide a comprehensive review of its current state.

Efficient degradation of norfloxacin by carbonized polydopamine-decorated g-CN activated peroxymonosulfate: Performance and mechanism.

The use of metal-free graphite carbon nitride (CN) to activate peroxymonosulfate (PMS) has attracted extensive attention for organic pollutants degradation. In this work, we prepared carbonized polydopamine-decorated g-CN (CP-700) for activation of PMS to degrade norfloxacin (NOR). The CP-700 composite was obtained by using CN as a base material on which dopamine underwent an autopolymerization reaction to form a CN-PDA complex, followed by pyrolysis.

FeN nanoparticles embedded in N-doped porous magnetic graphene for peroxymonosulfate activation: Radical and nonradical mechanism.

The persistence of pharmaceutical and personal care products (PPCPs) such as norfloxacin (NFX) poses a serious threat to the water environment, and the development of efficient and cost-effective advanced oxidation catalysts is an important step toward resolving this issue. Herein, Fe and N co-doped graphene (FeNGO) was synthesized from graphene oxide (GO), urea, and iron salt via simple impregnation pyrolysis, and applied for activating peroxymonosulfate (PMS) to degrade NFX. FeNGO possessed a two-dimensional porous sheet structure and was rich in defects, nitrogen species, and active sites.

Synthesis of Porous Biochar Containing Graphitic Carbon Derived From Lignin Content of Forestry Biomass and Its Application for the Removal of Diclofenac Sodium From Aqueous Solution.

Porous biochar containing graphitic carbon materials have received great attention from various disciplines, especially for environmental pollutant treatment, due to their cost-effective and specific textural properties. This study exhibited a two-step strategy to compose lignin-porous biochar containing graphitic carbon (LPGC) from pitch pine sawdust and investigated its adsorptive removal for diclofenac sodium (DCF) from an aqueous solution. Sulfuric acid (HSO) was utilized to obtain lignin content from biomass and potassium ferrate (KFeO) and was adopted to fulfill the synchronous carbonization and graphitization of LPGC.

Synthesis a graphene-like magnetic biochar by potassium ferrate for 17β-estradiol removal: Effects of AlO nanoparticles and microplastics.

A graphene-like magnetic biochar (GLMB) was synthesized using lotus seedpod and potassium ferrate with simple step and applied for E2 adsorption. GLMB was characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS), Raman, X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and BET surface area. Several common (solution pH, ionic strength, humic acid and foreign ions) and new (AlO nanoparticles and microplastics (MPs)) water experiment conditions were investigated.

Adsorption studies of 17β-estradiol from aqueous solution using a novel stabilized Fe-Mn binary oxide nanocomposite.

The removal of 17β-estradiol (E2) from contaminated water on nanoscale Fe-Mn binary oxide-loaded multiwalled carbon nanotubes (MWCNTs/FMBO) was evaluated in this work. The characterizations of the mesoporous adsorbent were analyzed by using SEM, TEM, VSM, XRD, XPS, and FTIR measurements. The effects of experimental conditions in E2 removal, including stabilizer additional level, adsorption time, initial E2 concentration, solution pH, reaction temperature, and foreign ions, were examined.

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. We discovered LSL-A6 (2-((2-carbamoyl-1-(3-(4-methoxyphenoxy)propyl)-1H-indol-6-yl)oxy)acetic acid) with a novel N-substituted indole scaffold to interfere Mcl-1 binding as a novel Mcl-1 inhibitor. Molecular modeling indicated that this compound binds with Mcl-1 by interaction with P2 and R263 hot-spots.