Systemic immune inflammation mediates the association of serum omega-3 and omega-6 polyunsaturated fatty acids with biological aging: a national population-based study.

Objective: This study aimed to explore the association between serum omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and biological aging, along with the potential mediating role of systemic immune inflammation (SII).

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were used for analyses. Accelerated aging in participants was assessed by calculating the difference between phenotypic age (PhenoAge) and chronological age.

An Unusual Cause of Complete Atrioventricular Block and Aortic Regurgitation.

We report a rare case of Behçet's disease (BD) causing aortic regurgitation and complete atrioventricular block (AVB) in conjunction with pacemaker pocket infection. We emphasize the need to consider the possibility of BD in young and middle-aged patients who present with aortic valve prolapse with regurgitation combined with complete AVB with elevated inflammatory markers.

Target organ damage in untreated hypertensive patients with primary aldosteronism.

An increased risk of target organ damage (TOD) has been reported in patients with primary aldosteronism (PA). However, there is relatively little related research on the correlation between the degree of TOD and those with and without PA in newly diagnosed hypertensive patients. The aim of this study was to assess the association between PA and TOD among patients with newly diagnosed hypertension.

Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment.

Aims/hypothesis: Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, identifying HFpEF in individuals with type 2 diabetes early on is often challenging due to a limited array of biomarkers. This study aims to investigate specific biomarkers associated with the progression of HFpEF in individuals with type 2 diabetes, for the purpose of enabling early detection and more effective management strategies.

Statin Therapy Is Associated With a Lower Risk of Heart Failure in Patients With Atrial Fibrillation: A Population-Based Study.

Background: Whether statin use can reduce the risk of heart failure (HF) remains controversial. The present study evaluates the association between statin use and HF in patients with atrial fibrillation.

Methods And Results: Patients with newly diagnosed atrial fibrillation from 2010 to 2018 were included.

Conditionals in context: Brain signatures of prediction in discourse processing.

Comprehenders are known to generate expectations about upcoming linguistic input at the sentence and discourse level. However, most previous studies on prediction focused mainly on word-induced brain activity rather than examining neural activity preceding a critical stimulus in discourse processing, where prediction actually takes place. In this EEG study, participants were presented with multiple sentences resembling a discourse including conditional sentences with either only if or if, which are characterized by different semantics, triggering stronger or weaker predictions about the possible continuation of the presented discourses, respectively.

Habitual physical activity improves outcomes among patients with myocardial infarction.

Purpose: This study evaluates the association between habitual physical activity (HPA) and the outcomes of patients with myocardial infarction (MI).

Methods: Patients newly diagnosed with MI were divided into two groups based on whether they engaged in HPA, defined as an aerobic activity with a duration of no less than 150 min/week, before the index admission. The primary outcomes included major adverse cardiovascular events (MACEs), cardiovascular (CV) mortality, and cardiac readmission rate 1 year following the index date of admission.

Language and face in interactions: emotion perception, social meanings, and communicative intentions.

Introduction: Human emotions can be complex to interpret as they have multiple sources and are often times ambiguous, for example, when the signals sent by different channels of communication are inconsistent. Our study investigates the interaction of linguistic and facial expressions of emotions.

Methods: In two experiments, participants read short scenarios in German containing a direct utterance with positive or negative emotive markers, in combination with different facial expressions as still images of the speaker (i.

Situating language register across the ages, languages, modalities, and cultural aspects: Evidence from complementary methods.

In the present review paper by members of the collaborative research center "Register: Language Users' Knowledge of Situational-Functional Variation" (CRC 1412), we assess the pervasiveness of register phenomena across different time periods, languages, modalities, and cultures. We define "register" as recurring variation in language use depending on the function of language and on the social situation. Informed by rich data, we aim to better understand and model the knowledge involved in situation- and function-based use of language register.

Cardioprotective Effect of Paeonol on Chronic Heart Failure Induced by Doxorubicin Regulating the miR-21-5p/S-Phase Kinase-Associated Protein 2 Axis.

Background: This study primarily explored the role of paeonol in doxorubicin (DOX)-induced chronic heart failure (CHF), considering the cardioprotective effect of paeonol on an epirubicin-induced cardiac injury.

Methods: DOX-induced CHF-modeled rats were treated with paeonol. Cardiac function and myocardial damage in rats were evaluated by using the multifunction instrument, and the histopathology, apoptosis, and the expression of miR-21-5p and S-phase kinase-associated protein 2 (SKP2) in myocardium were detected.

Processing Attenuating NPIs in Indicative and Counterfactual Conditionals.

Both indicative and counterfactual conditionals are known to be licensing contexts for negative polarity items (NPIs). However, a recent theoretical account suggests that the licensing of attenuating NPIs like English in the conditional antecedent is sensitive to pragmatic differences between various types of conditionals. We conducted three behavioral experiments in order to test key predictions made by that proposal.

Role of Cardiomyocyte-Derived Exosomal MicroRNA-146a-5p in Macrophage Polarization and Activation.

Myocardial infarction arises from an excessive or prolonged inflammatory response, leading to ventricular remodeling or impaired cardiac function. Macrophages exhibit different polarization types associated with inflammation both at steady state and after myocardial infarction. Exosomal miR-146a-5p has been identified as an important molecule in the cardiovascular field in recent years.

Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques.

Variants of concern (VOCs) like Delta and Omicron, harbor a high number of mutations, which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies (NAbs). In this study, Rhesus macaques immunized with 2-dose inactivated vaccines (Coronavac) were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine, or a bivalent inactivated vaccine (Beta and Delta) to determine the effectiveness of sequential immunization. The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type, Beta, Delta, and Omicron.

Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants.

Background: The Omicron (B.1.1.

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted on mink farms between minks and humans in many countries. However, the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown. Here, we demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation (dpi).

Antilocality effect without head-final dependencies.

Antilocality effects provide strong evidence for expectation-based sentence parsing models. Previous discussion of the antilocality effect, however, largely focused on the argument-verb dependencies in verb-final constructions, for which a memory retrieval-based account has been argued to be equally adequate. To test whether the principles of expectation/memory-based accounts hold for a wider range of dependencies, we report on two self-paced reading experiments that compared two different determiners in German: the morphologically complex determiner 'the-jenig,' which obligatorily requires a relative clause, and the bare determiner 'the,' which does not trigger such expectations.

The Processing of Negation and Polarity: An Overview.

Negation is a universal component of human language; polarity sensitivity (i.e., lexical distributional constraints in relation to negation) is arguably so while being pervasive across languages.

Bias and Modality in Conditionals: Experimental Evidence and Theoretical Implications.

The concept of bias is familiar to linguists primarily from the literature on questions. Following the work of Giannakidou and Mari (Truth and Veridicality in Grammar and Thought: Modality, Mood, and Propositional Attitudes, University of Chicago Press, Chicago, 2021), we assume "nonveridical equilibrium" (implying that p and ¬p as equal possibilities) to be the default for epistemic modals, questions and conditionals. The equilibrium of conditionals, as that of questions, can be manipulated to produce bias (i.

Semantics Processing of Conditional Connectives: German wenn 'if' Versus nur wenn 'only if'.

In this paper, the meaning and processing of the German conditional connectives (CCs) such as wenn 'if' and nur wenn 'only if' are investigated. In Experiment 1, participants read short scenarios containing a conditional sentence (i.e.