Sleep disturbances among older adults from the Russian Far East experiencing social loss: is there a sex difference?

Background: Maintaining sleep health in the elderly is of great significance for promoting health equity. The elderly usually experience more social losses, which may lead to many health problems. Few studies have revealed the relationship between social losses and sleep disturbance in the elderly.

The multidimensional orientation toward dying and death inventory: cross-cultural translation and validated in Mainland China participants.

Background: The negative impact of over-treatment in end-of-life individuals has led to attention to the value of death. Reassessing the attitude of death and dying can improve care and improve the quality of life. Therefore, the use of multidimensional tools to comprehensively assess the attitudes of individuals on dying and death, identify attitude tendencies and causes meaningful, and evaluate the effectiveness of the tools is an important prerequisite.

Enhancing the Stability of Sweet Protein Neoculin for Food Applications Using Computational Strategies.

Sweet proteins, known for their high sweetness and low caloric content, offer great potential as safe, low-calorie sweeteners without the negative health effects associated with sugar or artificial alternatives. Neoculin, unique for its dual properties of sweetness and taste-modifying, holds significant promise for food industry applications. However, its low thermal stability limits its broader use in food processing, highlighting the need to improve its stability.

[Mini-barcode combined with ITS2 for identification of bulk Artemisiae Scopariae Herba].

Artemisiae Scoporiae Herba is derived from Artemisia scoparia or A. capillaris. The accurate identification of the herbs, particularly when dealing with bulk samples, is critical for ensuring the quality and efficacy of the medicinal product.

Engineering a cpGFP-based biosensor for enhanced quantification of glycolate production in Escherichia coli.

The growing demand for glycolate, fueled by economic development, requires the advancement of production methods. Escherichia coli (E. coli), a preferred host for glycolate production, has undergone extensive metabolic engineering to improve yield.

Bibliometric and visual analyses of vaccine literacy research from 1982 to 2023.

Vaccine literacy (VL) is an important part of health literacy (HL), which is of great significance in reducing vaccine hesitancy and improving vaccine coverage rate. We aimed to perform a bibliometric analysis of VL research conducted from 1982 to 2023 to evaluate its current status and prospects. All relevant publications were retrieved from the Web of Science Core Collection database and the Scopus database.

Optimizing prolyl hydroxylation for functional recombinant collagen in Escherichia coli.

Collagen, a key extracellular matrix component, is renowned for its biocompatibility, biodegradability, and bioactivity, finding wide applications in food, medicine, cosmetics, and industry. Recombinant collagen expression in Escherichia coli offers advantages such as shorter production cycles and lower costs compared to extraction from animal tissues, though it is known to lack essential post-translational modifications, such as proline hydroxylation, which are crucial for its stability and biological function. Studies have shown that certain prolyl hydroxylases, including BaP4H, DsP4H, and L593, exhibit relatively high modification efficiency in the E.

Healthcare workers perceptions of patient safety culture in selected Ghanaian regional hospitals: a qualitative study.

Background: Patient safety culture is an integral part of healthcare delivery both in Ghana and globally. Therefore, understanding how frontline health workers perceive patient safety culture and the factors that influence it is very important. This qualitative study examined the health workers' perceptions of patient safety culture in selected regional hospitals in Ghana.

A Cysteine-Maleimide-Based Design for Hemostatic, Antibacterial, and Biodegradable Wound Dressing.

The field of clinical surgery frequently encounters challenges related to atypical wound tissue healing, resulting in the development of persistent chronic wounds or aesthetically displeasing scar tissue. The use of wound dressings crafted from mussel adhesive proteins and hyaluronic acid has demonstrated the potential in mitigating these undesirable outcomes. However, the synergistic effects of these two biomaterials remain underexplored.

Computational design towards a boiling-resistant single-chain sweet protein monellin.

Sweet proteins offer a promising solution as sugar substitutes by providing a sugar-like sweetness without the negative health impacts linked to sugar or artificial sweeteners. However, the low thermal stability of sweet proteins has hindered their applications. In this study, we took a computational approach utilizing ΔΔG calculations in PyRosetta to enhance the thermostability of single-chain monellin (MNEI).

The need for digital health education among next-generation health workers in China: a cross-sectional survey on digital health education.

Background: Digital health is important for sustainable health systems and universal health coverage. Since the outbreak of COVID-19, many countries, including China, have promoted the introduction of digital health in their medical services. Developing the next generation of physicians with digital health knowledge and skills is a prerequisite for maximizing the potential of digital health.

Corrigendum to "Overview and analysis of the text mining applications in the construction industry" [Heliyon 8 (12) (December 2022) Article e12088].

[This corrects the article DOI: 10.1016/j.heliyon.

Overview and analysis of the text mining applications in the construction industry.

The data generation in the construction industry has increased dramatically. The major portion of the data in the architecture, engineering and construction (AEC) domain are unstructured textual documents. Text mining (TM) has been introduced to the construction industry to extract underlying knowledge from unstructured data.

Challenges in current construction and demolition waste recycling: A China study.

China produced a large amount of construction and demolition (C&D) waste, owing to the rapid development of construction industry. Although a set of policies and regulations are being drafted in China for promoting C&D waste recycling, execution of these policies in practice seems to be far from effective. Currently, approximately 75% of Chinese cities are still surrounded by large volumes of C&D waste.

Mixed receptors of AMPA and NMDA emulated using a 'Polka Dot'-structured two-dimensional conjugated polymer-based artificial synapse.

In a biological synapse, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate fast excitatory neurotransmission, whereas N-methyl-d-aspartate (NMDA) receptors trigger an enhanced memory effect; the complementary roles of AMPA and NMDA are essential in short-term plasticity (STP) to enhance memory effect (EME) transition. Herein, we report the design and fabrication of the first two-dimensional (2D) conjugated polymer (CP)-based synaptic transistor. The special design of the 2D CP with nanoscale-segregated 'polka dot'-structured crystalline phases and adjacent amorphous phases emulate the different receptors of NMDA and AMPA on the postsynaptic membrane for the first time.

Evolution of Bio-Inspired Artificial Synapses: Materials, Structures, and Mechanisms.

Artificial synapses (ASs) are electronic devices emulating important functions of biological synapses, which are essential building blocks of artificial neuromorphic networks for brain-inspired computing. A human brain consists of several quadrillion synapses for information storage and processing, and massively parallel computation. Neuromorphic systems require ASs to mimic biological synaptic functions, such as paired-pulse facilitation, short-term potentiation, long-term potentiation, spatiotemporally-correlated signal processing, and spike-timing-dependent plasticity, etc.

Artificial synapses based on nanomaterials.

Artificial synapses emulate biological synaptic signals in neuromorphic systems to attain brain-like computation and autonomous learning behaviors in non-von-Neumann systems. Several classes of materials have been applied to this field to achieve numerous functionalities of biological synapses. Nanomaterials (NMs), such as one-dimensional (1D) and two-dimensional (2D) NMs have shown great potential due to their nanometer feature size (1D) and molecular-level thickness (2D).