The Molecular Mechanism of a Complex1-Induced Apoptosis in Cancer Cells of the Esophagus.

Background: Esophageal Cancer (EC) is a commonly occurring cancer of the digestive tract. The bismuth compounds from thiosemicarbazones have been observed to be active against cancer cells. However, a synthetic nine-coordinate bismuth (III) complex (complex 1) has never been assessed so far for its anticancer in the esophageal squamous cell carcinoma cell line (EC109).

A study on the variation of cytokine and electrolyte levels in rhesus macaques, cynomolgus monkeys, and Assamese macaques.

Background: Non-human primates (NPHs), such as rhesus macaques, cynomolgus monkeys, and Assamese macaques, play a crucial role in biomedical research. However, baseline cytokine and electrolyte data for these three species, particularly data stratified by age and sex, are limited. Therefore, the aim of this study was to establish and analyze age- and sex-specific cytokine and electrolyte profiles in these three species.

High-Efficiency Broad-Spectrum Antibacterial Activity of Chitosan/Zinc Ion/Polyoxometalate Composite Films for Water Treatment.

The development of multifunctional films with rapidly killing microorganisms and adsorbing residual antibiotics in wastewater remains a challenging endeavor. In this work, the chitosan/zinc ion/polyoxometalate (CS/Zn/POM) multifunctional films were prepared by the freeze-drying method using chitosan, ZnO, and POM. Notably, the CS/Zn/POM films exhibited excellent bactericidal properties against Gram-positive/negative bacterial strains including (, 99.

Soil Emissions of Reactive Oxidized Nitrogen Reduce the Effectiveness of Anthropogenic Source Control in China.

Nitrogen dioxide (NO) has decreased by ∼33% across over 1200 monitoring sites in China during 2015-2023, following a series of clean air policies. However, most of these sites are located in or near cities, leading to uncertainties in NO trends beyond urban regions due to limited observations. Here, we used satellite measurements to examine the differences in NO trends between urban and rural China.

Establishment of a rhesus macaque model for coxsackievirus A6 infection: Pilot study to evaluate infection initiated through the respiratory or digestive track.

Coxsackievirus A6 (CVA6) is a primary pathogen associated with hand, foot, and mouth disease (HFMD) and is typified by fever, rashes or herpetic lesions at distinct locations. Although HFMD patients exhibit mild symptoms, a subset of patients may develop severe complications, such as viral encephalitis, myocarditis, pneumonia, and neurological disorders. However, in addition to rodent models, such as the CVA6-infected mouse model, no definitive nonhuman primate animal model or related research or analysis tool is available, which makes the development of suitable nonhuman primate animal models particularly crucial.

Polyoxometalates and their composites for antimicrobial applications: Advances, mechanisms and future prospects.

The overuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be even more difficult to treat and pose an even greater threat to public health. In order to address the issue of antibiotic-resistant bacteria, researchers currently are exploring alternative methods of sterilization that are both effective and sustainable. Polyoxometalates (POMs), as emerging transition metal oxide compounds, exhibit significant potential in various applications due to their remarkable tunable physical and chemical performance, especially in antibacterial fields.

Combination of oxidative and reductive effects of phenolic compounds on the degradation of aniline disinfection by-products by free radicals.

In this study, we selected 13 phenolic compounds containing -COOH, -CHO, -OH, and -COCH functional groups as model compounds for dissolved organic matter (DOM), and explored the redox reactions during the co-degradation of phenolic compounds with aniline disinfection by-products (DBPs) at the molecular level. When phenolic compounds and aniline DBPs were degraded, phenoxy radicals and aniline radicals were the most important intermediates. Phenoxy radicals can degrade aniline DBPs via hydrogen atom abstraction (HAA) reactions, and the reaction rates were related to the reduction potentials of the compounds.

Theoretical evidence for a pH-dependent effect of carbonate on the degradation of sulfonamide antibiotics.

Carbonate (CO/HCO) have a significant impact on advanced oxidation processes (AOPs) by consuming reactive free radicals such as HO to generate CO. However, research on the mechanisms and kinetics of CO remains limited. This study investigates the degradation mechanism and kinetics of sulfonamide antibiotics (SAs) by CO through theoretical calculations.

A 3-month-old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism.

Coxsackievirus B1 (CVB1), an enterovirus with multiple clinical presentations, has been associated with potential long-term consequences, including hand, foot, and mouth disease (HFMD), in some patients. However, the related animal models, transmission dynamics, and long-term tissue tropism of CVB1 have not been systematically characterized. In this study, we established a model of CVB1 respiratory infection in rhesus macaques and evaluated the clinical symptoms, viral load, and immune levels during the acute phase (0-14 days) and long-term recovery phase (15-30 days).

A novel controllable capacitor commutation based superconducting hybrid direct current breaker.

Featuring low power loss and high reliability, voltage source converter medium voltage direct current (VSC-MVDC) systems have been widely employed for grid-tied renewable energy applications. To maintain high operational safety, circuit breakers are needed to isolate faulted powerlines by comprehensively considering response speed and installation cost. Research efforts have been put to realizing DC fault isolation by coordinating resistive type superconducting fault current limiter (R-SFCL) and integrated-gate-commutated-thyristor (IGCT) based hybrid DC circuit breaker.

Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey.

Coxsackievirus B3 (CVB3) is the pathogen causing hand, foot and mouth disease (HFMD), which manifests across a spectrum of clinical severity from mild to severe. However, CVB3-infected mouse models mainly demonstrate viral myocarditis and pancreatitis, failing to replicate human HFMD symptoms. Although several enteroviruses have been evaluated in Syrian hamsters and rhesus monkeys, there is no comprehensive data on CVB3.

Microbial community, pathogenic bacteria and high-risk anti-biotic resistance genes at two tropical coastal beaches adjacent to villages in Hainan, China.

Objective: The aim of the study was to explore the correlation between characteristics of microbial community, pathogenic bacteria and high-risk antibiotic-resistant genes, between coastal beaches and a multi-warm-blooded host, as well as to determine potential species biomarkers for faecal source contamination on tropical coastal beaches in China.

Material And Methods: The 'One-Health' approach was used in a microbiological study of beaches and warm-blooded hosts. The microbial.

A Compact RF Energy Harvesting Wireless Sensor Node with an Energy Intensity Adaptive Management Algorithm.

This paper presents a compact RF energy harvesting wireless sensor node with the antenna, rectifier, energy management circuits, and load integrated on a single printed circuit board and a total size of 53 mm × 59.77 mm × 4.5 mm.

A Compact Stacked RF Energy Harvester with Multi-Condition Adaptive Energy Management Circuits.

This paper presents a compact stacked RF energy harvester operating in the WiFi band with multi-condition adaptive energy management circuits (MCA-EMCs). The harvester is divided into antennas, impedance matching networks, rectifiers, and MCA-EMCs. The antenna is based on a polytetrafluoroethylene (PTFE) substrate using the microstrip antenna structure and a ring slot in the ground plane to reduce the antenna area by 13.

Effect of pH on UV/HO-mediated removal of single, mixed and halogenated parabens from water.

Adjusting pH values in aqueous environments can significantly improve the efficiency by which parabens and halo-parabens are removed. In this study, 20 neutral and deprotonated species were selected as models to investigate their pH-dependent removal mechanisms and kinetics by a UV/HO process using density functional theory (DFT). Compared to neutral species, deprotonated species exhibit higher reactivity to HO due to their high electron cloud density.

Differences in the degradation behavior of disinfection by-products in UV/PDS and UV/HO processes and the effect of their chemical properties.

In this work, sixteen typical chlorinated and brominated aromatic disinfection by-products (DBPs) were selected as examples to investigate their different degradation mechanisms initiated by HO• and SO•. Addition reactions were the main mode of degradation of DBPs by HO•, while SO• dominated H-abstraction reactions and single electron transfer reactions. Chlorinated compounds had higher reactivity than brominated compounds.

Homogeneous and heterogeneous atmospheric ozonolysis of chlorobenzene:Mechanism, kinetics and ecotoxicity assessment.

The reactions between chlorobenzene(CB) and ozone have been studied comprehensively in this paper. Chlorobenzene is a commonly found chlorinated aromatic volatile organic compound(VOC), and its emission into the atmosphere can cause harm to the ecosystem and human health. The frequent occurrence of mineral particles from sandstorms exerts a significant influence on the atmospheric chemistry of the troposphere.

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1.

Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it is crucial. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) have been shown to be harmless to COVID-19 patients, but it remains elusive whether ACEIs/ARBs have protective benefits to them.

Efficient removal of Cl-DBPs by direct-indirect continuous hydrodechlorination reduction reaction on TiCX surface: A theoretical calculation.

Degradation of Chlorine-containing disinfection by-products(Cl-DBPs) on surface by electrocatalytic hydrodechlorination (EHDC) is considered a promising advanced water treatment method. Cl-DBPs have ecological toxicity and health risks so that it is urgent to degrade DBPs. We designed and verified the degradation performance of the EHDC of 18 kinds of DBPs (TAAs, TANs, TALs, TNMs, TAcAms, THMs) with different substituents led by the TiCX(X = O/OH) system by the first-principles.