Numerical study on the evolution characteristics of contact and fluid flow in shear-induced rough joint.

In order to investigate the influence of shear on contact characteristics and fluid flow evolution of rough rock fractures, a series of shear-flow tests were carried out by numerical experiments. Firstly, a sandstone specimen with a rough fracture was made in the laboratory, and the numerical model of the fracture was reconstructed in FLAC3D software. Experiments were conducted to investigate the depth of penetration of the fracture under different normal stress (1, 3, and 5 MPa) and shear displacement (2, 4, 6, 8, and 10 mm).

Spatiotemporally Controlled T-Cell Combination Therapy for Solid Tumor.

Due to multidimensional complexity of solid tumor, development of rational T-cell combinations and corresponding formulations is still challenging. Herein, a triple combination of T cells are developed with Indoleamine 2,3-dioxygenase inhibitors (IDOi) and Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). To maximize synergism, a spatiotemporally controlled T-cell engineering technology to formulate triple drugs into one cell therapeutic, is established.

Experimental and numerical investigation of the mechanical properties and energy evolution of sandstone-concrete combined body.

Studying the mechanical properties of rock-concrete combined body is crucial to ensure the safety and stability of engineering structures. In this paper, laboratory tests and numerical simulations are used to investigate the mechanical properties of the sandstone-concrete combined body. Uniaxial compression tests and an acoustic emission monitoring system are used to analyze the failure characteristics of the sandstone-concrete sample and to validate the accuracy of the numerical model.