To analyze the differences and dynamic changes in the color, odor, and major chemical components of Astragali Radix during honey processing, this study used a CM-5 spectrophotometer and Hercules NEO ultra-fast gas phase electronic nose for analysis. High performance liquid chromatography was employed to determine the content of calycosin, calycosin-7-glucoside, formononetin, and ononin in the Astragali Radix decoction pieces processed with honey to different degrees. Multivariate statistical analyses including partial least squares-discriminant analysis(PLS-DA), orthogonal partial least squares-discriminant analysis(OPLS-DA), differential factor analysis(DFA), and Bayesian discriminant analysis were adopted to differentiate the Astragali Radix decoction pieces processed with honey to different degrees and evaluate the correlations between visual characteristics and chemical composition.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Surgical resection and high-dose radiotherapy constitute the standard therapeutic approaches for chordoma. However, the efficacy of radiotherapy is often compromised by the tumor microenvironment's hypoxic conditions, which confer radiation resistance, and by the potential damage to adjacent spinal cord and neural structures from elevated radiation doses. To address these challenges, we employed high biocompatible poly(vinylpyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) as a potent radiosensitizer to augment the radiotherapy sensitivity of chordoma.
View Article and Find Full Text PDFis a major producer of ochratoxin A (OTA), a highly toxic and carcinogenic mycotoxin found in various food and feed products. produces excessive amount of OTA under various water activity (a) conditions that occur during food and feed storage. The biosynthetic gene clusters associated with OTA production include , which plays a key role in controlling mycotoxin production in response to environmental conditions.
View Article and Find Full Text PDFPlant Cell Physiol
December 2024
Rocketing labor cost is a major challenge threatening agricultural sustainability and food security worldwide. The replacement of manual pruning of horticultural plants with chemical pruning has long been a goal for saving cost and reducing virus spreading. Here, guided by the structure-function relationship of allelochemical benzoic acid derivatives, we have identified 4-(2-phenylethynyl)-benzoicacid (PEBA) as a highly bioactive compound.
View Article and Find Full Text PDFMorphological changes of trehalose crystals during drying and reprocessing lead to a series of post-processing problems, which result in a significant investment in production costs. In this work, the mechanism of drying temperature on the morphology and caking behavior of trehalose was investigated. When the drying temperature was too high (≥393.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Ionic thermoelectric materials, renowned for their high Seebeck coefficients, are gaining prominence for their potential in harvesting low-grade waste heat. However, the theoretical underpinnings for enhancing the performance of these materials remain underexplored. In this study, the Hoffmeister effect was leveraged to augment the thermoelectric properties of hydrogel-based ionic thermoelectric materials.
View Article and Find Full Text PDFIn this study, an eco-friendly and designable aqueous two-phase system (ATPS) was developed using natural deep eutectic solvents (DES) and short-chain alcohols. The formation mechanism and influence of various factors on phase behavior were investigated. Optimal extraction parameters were determined through single-factor experiments and response surface methodology (RSM): 45 °C temperature, 45 % -propanol, 40 % DES, and 0.
View Article and Find Full Text PDFAt present, the matrix interference in traditional Chinese medicine (TCM) is still a great challenge for multi-residue pesticides analysis. Herein, an alcohol/salt aqueous two-phase system (ATPS) based on n-propanol and (NH)SO was developed by comparing the binodal curve phase diagrams and the extraction rates of pesticides. The specific extraction conditions, including the composition of the ATPS, temperature, pH, and extraction time were explored through single factor experiments, and subsequently optimized using orthogonal array design and response surface methodology.
View Article and Find Full Text PDFIn this study, the drying kinetics and multidimensional quality of Gastrodia elata (GE) obtained through five different drying methods were analyzed. The Page model provided the best fit. Though widely used, hot-air drying (HA-D) showed mediocre performance.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2024
Proteins belonging to the STAND (signal transduction ATPases with numerous domains) family have been implicated in crucial functions across various signal transduction pathways, encompassing both apoptosis and innate immune responses. In this study, we have identified NWD1, a member of the STAND superfamily, as a gene that regulates neurite outgrowth. This was confirmed by siRNA knockdown assay in E18 neurons.
View Article and Find Full Text PDFSpatial information and dynamic locomotor behaviours are equally important for achieving locomotor goals during spatial navigation. However, it remains unclear how spatial and locomotor information is integrated during the processing of self-initiated spatial navigation. Anatomically, the retrosplenial cortex (RSC) has reciprocal connections with brain regions related to spatial processing, including the hippocampus and para-hippocampus, and also receives inputs from the secondary motor cortex.
View Article and Find Full Text PDFAcute liver failure (ALF) is characterized by the rapidly progressive deterioration of hepatic function, which, without effective medical intervention, results in high mortality and morbidity. Here, using proteomic and transcriptomic analyses in murine ALF models, we found that the expression of multiple splicing factors was downregulated in ALF. Notably, we found that KH-type splicing regulatory protein (KHSRP) has a protective effect in ALF.
View Article and Find Full Text PDFThe melt pools, the most basic units of the components fabricated by the selective laser melting (SLM) technology, play an important role in the mechanical properties of the structures. A self-developed in-situ tensile observation platform was used to carry out the in-situ tensile test of SLMed AlSi10Mg alloy specimens under the observation of optical microscope. With a series of obtained experimental data on mechanical properties and metallurgical images, combined with the digital image correlation(DIC) technology, the melt pool of the specimen and the strain of defects were analyzed, and the deformation and fracture mechanism of the SLMed AlSi10Mg alloy specimens was obtained.
View Article and Find Full Text PDFGene Expr Patterns
September 2024
Wnt signal is crucial to correctly regenerate tissues along the original axis in many animals. Lizards are able to regenerate their tails spontaneously, while the anterior-posterior axis information required for the successful regeneration is still elusive. In this study, we investigated the expression pattern of Wnt ligands and HOX genes during regeneration.
View Article and Find Full Text PDFLow-light images are prevalent in intelligent monitoring and many other applications, with low brightness hindering further processing. Although low-light image enhancement can reduce the influence of such problems, current methods often involve a complex network structure or many iterations, which are not conducive to their efficiency. This paper proposes a Zero-Reference Camera Response Network using a camera response model to achieve efficient enhancement for arbitrary low-light images.
View Article and Find Full Text PDFBackground: Masked hypertension is associated with target organ damage (TOD) and adverse health outcomes, but whether antihypertensive treatment improves TOD in patients with masked hypertension is unproven.
Methods: In this multicentre, randomised, double-blind, placebo-controlled trial at 15 Chinese hospitals, untreated outpatients aged 30-70 years with an office blood pressure (BP) of <140/<90 mm Hg and 24-h, daytime or nighttime ambulatory BP of ≥130/≥80, ≥135/≥85, or ≥120/≥70 mm Hg were enrolled. Patients had ≥1 sign of TOD: electrocardiographic left ventricular hypertrophy (LVH), brachial-ankle pulse wave velocity (baPWV) ≥1400 cm/s, or urinary albumin-to-creatinine ratio (ACR) ≥3.
Backgrounds: Current observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated. Consequently, this study is designed to evaluate the causal interconnection between ankylosing spondylitis and cardiovascular-related conditions utilizing a bidirectional two-sample Mendelian Randomization (MR) methodology.
View Article and Find Full Text PDFIntroduction: Pepper ( spp.) is a vegetable that is cultivated globally and has undergone extensive domestication, leading to a significant diversification in its agronomic traits. With the advancement of genomics in pepper and the reduction in sequencing costs, the high-throughput detection of single nucleotide polymorphisms (SNPs) and small insertions-deletions (indels) has become increasingly critical for analyzing pepper germplasms and improving breeding programs.
View Article and Find Full Text PDFBackground: Inflammation triggers atherosclerotic plaque rupture, leading to acute myocardial infarction (AMI). Following AMI, peri-coronary adipose tissue (PCAT) undergoes a transition from lipid-rich to hydrophilic characteristics due to vascular inflammation. This study investigates PCAT changes and neutrophil-to-lymphocyte ratio levels during AMI.
View Article and Find Full Text PDFLarge-area oriented ZnO nanoarrays (including nanowire, nanorod, and nanotube) on ITO glass substrates are synthesized via the simple hydrothermal, electrodeposition, and electrochemical etching approach. The morphology of ZnO nanoarrays is controlled by adjusting the reaction temperature, reaction time, and current density. The scanning and transmission electron microscopy (SEM and TEM) results indicate the successful preparation of large-area oriented ZnO nanoarrays with different types, and the energy-dispersive X-microanalysis spectrum (EDS) and X-ray diffraction (XRD) results confirm that the composition of the obtained nanoarrays is ZnO.
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