An AI recognition method for children's clinical operative pain by skin potential (SP) signal.

Objective And Rationale: Children's clinical pain phenotypes are complex, and there is a lack of objective biological diagnostic markers and cognitive patterns. Detecting physiological signals through wearable devices simplifies disease diagnosis and holds the potential for remote medical applications.

Method And Results: This research established a pain recognition model based on AI skin potential (SP) signal analysis.

Experimental and Numerical Analysis of Bolted Repair for Composite Laminates with Delamination Damage.

Composite materials are widely used in aircraft due to the urgent need for high-quality structures in aerospace engineering. In order to verify the effectiveness of complex bolt repairs on composite structures, compression tests have been performed on three types (intact, damaged, and repaired) of composite plate specimens, and finite element simulation results of these three types' specimens were obtained. The experimental results show that for damaged composite laminates, the strength recovery after bolt repair can reach an impressive 107%, and the delamination propagation caused by over-buckling deformation is considered to be the main cause of failure, which also suggests that although bolt repair can improve the strength of the specimens, it has a limited ability to inhibit delamination propagation.

The MnO/GelMA Composite Hydrogels Improve the ROS Microenvironment of Annulus Fibrosus Cells by Promoting the Antioxidant and Autophagy through the SIRT1/NRF2 Pathway.

Intervertebral disc degeneration (IVDD) is a worldwide disease that causes low back pain and reduces quality of life. Biotherapeutic strategies based on tissue engineering alternatives, such as intervertebral disc scaffolds, supplemented by drug-targeted therapy have brought new hope for IVDD. In this study, to explore the role and mechanism of MnO/GelMA composite hydrogels in alleviating IVDD, we prepared composite hydrogels with MnO and methacrylate gelatin (GelMA) and characterized them using compression testing and transmission electron microscopy (TEM).

Influence of proteolytic enzyme treatment on the changes in volatile compounds and odors of beef longissimus dorsi.

Enzymatic tenderization is extensively applied in the meat industry, whereas its influence on meat flavor has seldom been evaluated. Proteinase K, papain, bromelain and Flavourzyme® were used to treat beef muscle, and the changes in volatile compounds and odors were subsequently analyzed. Proteolysis by proteinase K was found to elevate the average bitterness of the identified peptides by generating peptides with high Q values, whereas proteolysis by papain generated the highest level of amino acids.