Exploiting the Zebrafish Model for Sepsis Research: Insights into Pathophysiology and Therapeutic Potentials.

Sepsis, a severe condition instigated by infections, continues to be a primary global cause of death, typified by systemic inflammation and advancing immune dysfunction. Comprehending the complex pathological processes that underlie sepsis is integral to the creation of efficacious treatments. Despite the inability of animal models to entirely reproduce the clinical intricacies related to sepsis, they are invaluable instruments for the exploration and development of therapeutic approaches.

The 6-hour lactate clearance rate in predicting 30-day mortality in cardiogenic shock.

Background: Early evaluation of prognosis in cardiogenic shock (CS) is crucial for tailored treatment selection. Both lactate clearance and lactate levels are considered useful prognostic biomarkers in patients with CS. However, there is yet no literature comparing the 6-hour lactate clearance rate (Δ6Lac) with lactate levels measured at admission (L1) and after 6 h (L2) to predict 30-day mortality in CS.

A comprehensive assessment of photosynthetic acclimation to shade in C4 grass (Cynodon dactylon (L.) Pers.).

Background: Light deficit in shaded environment critically impacts the growth and development of turf plants. Despite this fact, past research has predominantly concentrated on shade avoidance rather than shade tolerance. To address this, our study examined the photosynthetic adjustments of Bermudagrass when exposed to varying intensities of shade to gain an integrative understanding of the shade response of C4 turfgrass.

Association of Thyroid Autoantibodies with Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients.

Background: Diabetic nephropathy (DN) is one of the most common and severe complications in patients with type 2 diabetes mellitus (T2DM). Thyroid dysfunction has been associated with diabetes and its complications but the relationship between thyroid autoantibodies and T2DM-DN remains unclear.

Objective: The study aims to investigate the association between thyroid autoantibodies and diabetic nephropathy in patients with T2DM and analyze the expression of serum thyroid hormone levels in T2DM-DN patients and its prognostic value.

BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages.

Background: Although the exosomes derived from mesenchymal stem cells (MSCs) display a therapeutic effect on inflammatory diseases, its application on OA has great limitations due to lack of specificity and targeting. The current study aimed to elucidate the potential therapeutic role of bone morphogenetic proteins-7(BMP-7) modified synovial mesenchymal stem cells-derived exosomes (SMSCs-exo) on OA and mechanism.

Methods: For in vitro experiments, LPS-treated macrophages RAW264.

Diversity analysis of agronomic and nutritional traits of hybrid offspring of forage bermudagrass.

Because of its excellent stress resistance and forage quality, the forage bermudagrass hybrid population had attracted the attention of scientific researchers in recent years. Studying its diversity could promote the breeding of desirable varieties. The variability in agronomic traits including fresh weight, dry weight, ash content, crude protein content, crude fat, phosphorus content, and relative feed value for 56 bermudagrass was investigated using Wrangler as an experimental reference.

The extended day length promotes earlier flowering of bermudagrass.

Day length is a very critical environmental factor affecting plant growth and development. The extension of light application time has been shown to promote flowering in the long-day plant and to shorten breeding time in some crops. However, previous research on the regulation of bermudagrass flowering by light application time is scarce.

Photosystem II photochemical adjustment of tall fescue against heat stress after melatonin priming.

High temperature is the key factor restricting the survival of tall fescue. Extreme summer hot events arise from global warming further increases this risk. As a candidate chemical priming agent previously reported, melatonin offers innovative solution to improve heat resistance of plants.

Relationship between Adverse Childhood Experiences and Mental Health in Chinese Adolescents: Differences among Girls and Boys.

The negative effects of adverse childhood experiences (ACEs) on individual mental health have been widely demonstrated, yet fewer studies have examined the impact of ACEs on depression and anxiety of Chinese adolescents and their sex differences. This cross-sectional study surveyed 12421 adolescents aged 10−17 in Hechi City, Guangxi Province, to measure their levels of ACEs, depression symptoms, and anxiety symptoms. The results found that: (1) Girls were more likely to experience ACEs than boys (37.

Seasonal to sub-seasonal variations of the Asian Tropopause Aerosols Layer affected by the deep convection, surface pollutants and precipitation.

The Asian Tropopause Aerosols Layer (ATAL) refers to an accumulation of aerosols in the upper troposphere and lower stratosphere during boreal summer over Asia, which has a fundamental impact on the monsoon system and climate change. In this study, we primarily analyze the seasonal to sub-seasonal variations of the ATAL and the factors potentially influencing those variations based on MERRA2 reanalysis. The ability of the reanalysis to reproduce the ATAL is well validated by CALIPSO observations from May to October 2016.

Impacts of meteorological parameters on the occurrence of air pollution episodes in the Sichuan basin.

Episodes of fine-particulate matter (PM) pollution are a widespread and common occurrence in China, and have potentially serious implications for human health. Meteorological conditions play an important role in air quality and influence the formation of regional air pollution episodes. This study applied a new classification method and daily PM concentration data to (a) evaluate different levels of air pollution in the Sichuan-Chongqing region between 2015 and 2017, and (b) investigate their relationships with meteorological parameters including atmospheric boundary layer height, wind speed, temperature inversion, weather type, and atmospheric transport.

The Older, the More Forgiving? Characteristics of Forgiveness of Chinese Older Adults.

This study explores the characteristics of forgiveness in the aging cohorts, which is regarded to be associated with healthy outcomes. Data were drawn from a sample of 308 older adults (aged from 60 to 98 years) who completed the forgiveness questionnaire: forgiving others of The Heartland Forgiveness Scale (HFS) to examine explicit forgiveness, and among the participants, 44 older adults were administrated on the variant single category of implicit association test (SC-IAT) to examine the implicit forgiveness. The results revealed that (1) there is no correlation between explicit forgiveness and implicit forgiveness of older adults.

Effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation.

To investigate the effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation. 70 patients with severe pneumonia complicated with respiratory failure who were treated with mechanical ventilation were selected and divided into the combined group and the control group. The control group underwent mechanical ventilation treatment and used dexmedetomidine for sedation and analgesia, while the combined group had sufentanil analgesia in addition to the treatment of the control group.

Water-soluble brown carbon in atmospheric aerosols along the transport pathway of Asian dust: Optical properties, chemical compositions, and potential sources.

As an important type of light-absorbing aerosol, brown carbon (BrC) has the potential to affect the atmospheric photochemistry and Earth's energy budget. A comprehensive field campaign was carried out along the transport pathway of Asian dust during the spring of 2016, including a desert site (Erenhot), a rural site (Zhangbei), and an urban site (Jinan), in northern China. Optical properties, bulk chemical compositions, and potential sources of water-soluble brown carbon (WS-BrC) were investigated in atmospheric total suspended particulate (TSP) samples.

A Pilot Study for Forgiveness Intervention in Adolescents With High Trait Anger: Enhancing Empathy and Harmony.

Forgiveness interventions benefit victims' mental health, reduce levels of anger, and promote forgiveness. However, forgiveness interventions are rarely used to improve the offender's anger and mental health, especially in specific situations such as juvenile correctional facilities. The offender is often also a victim, and reducing the offender's excessive anger may prevent or decrease the likelihood of future interpersonal violence.

Interannual variability of dust height and the dynamics of its formation over East Asia.

The vertical structure of dust layers is rarely investigated, despite its critical role in exploring the radiative and microphysical effects of dust aerosols. In this study, we primarily investigate the temporal variability of most probable dust height (MPDH) over dust source regions in East Asia and its interactions with climate parameters using CALIPSO lidar measurements under cloud-free conditions in spring from 2007 to 2018. The vertical profile of dust aerosols exhibits significant interannual variability over this time; dust is mainly concentrated below 7 km and associated with a dust occurrence frequency (DOF) of 0.

Dietary inflammatory index and cardiovascular risk and mortality: A meta-analysis of cohort studies.

Background: The role of dietary inflammatory index (DII) in cardiovascular disease (CVD) risk and mortality is still controversial. This systematic review and meta-analysis of cohort studies aimed to evaluate the effect of DII, indicating a pro-inflammatory diet, on the incidence and mortality of CVD.

Methods: A comprehensive literature search of articles published through August 2019 was performed in Medline, EMBASE, and Web of Science.

Alcohol Consumption and Risk for Venous Thromboembolism: A Meta-Analysis of Prospective Studies.

The association between alcohol consumption and venous thromboembolism (VTE) risk has been investigated by various observational studies with inconsistent results. We examined this association by performing a meta-analysis of prospective studies. A comprehensive literature search was carried out in the PubMed, EMBASE, and Web of Science from its inception to February 2020.

Inhibitory effect of 5-Fluorouracil on the proliferation of human osteosarcoma cells in vitro.

Purpose: To evaluate the inhibitory effect of 5-fluorouracil (5-FU) in combination with cisplatin on the proliferation of human osteosarcoma cells in vitro.

Methods: Three groups of human osteosarcoma U2OS cells were cultured in DMEM medium supplemented with the following drugs: 20 µg/mL 5-FU, 50 µg/mL 5-FU and 50 µg/mL 5-FU in combination with 0.5 mg/L cisplatin.

The effect of diabetes on the risk and mortality of acute lung injury/acute respiratory distress syndrome: A meta-analysis.

Background: The role of pre-existing diabetes in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is still controversial. This systematic review and meta-analysis of observational studies aimed to evaluate the effect of diabetes on the risk and mortality of ALI/ARDS.

Methods: A comprehensive literature search was performed in PubMed, Scopus, Cochrane Central Register of Controlled Trails and Web of Science for their inception to September 2018.

Effects of SI and PCV on respiratory mechanics, early central drive and hemodynamics in patients with ARDS.

Effects of sustained inflation (SI) and pressure- controlled ventilation (PCV) on respiratory mechanics, early central drive, and hemodynamics in patients with acute respiratory distress syndrome (ARDS) were investigated and compared. A retrospective analysis of 26 patients with ARDS, who were admitted to the Yiwu Central Hospital from March 2015 to March 2016, was performed. According to the ventilation method adopted by the patients with ARDS, 13 patients who received SI treatment were included in the SI group and 13 patients who received PCV treatment were included in the PCV group.

The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury.

Background: Fibrinogen-like protein 2 (FGL2) is an inflammatory procoagulant protein. We discerned the impact of serum FGL2 on trauma severity and 30-day mortality in patients with traumatic brain injury (TBI).

Methods: A total of 114 severe TBI patients were subjected to assessment of trauma severity using the Glasgow coma scale (GCS).

The effects of statin therapy on mortality in patients with sepsis: A meta-analysis of randomized trials.

Background: Much controversy persists regarding the role of statins therapy in patients with sepsis. This systematic review and meta-analysis of randomized trials aimed to evaluate the clinical efficacy of statin therapy on mortality from sepsis.

Methods: We comprehensively searched PubMed, Embase, and Cochrane controlled trials register for relevant clinical studies.

Effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response and antioxidant capacity of ARDS.

Acute respiratory distress syndrome (ARDS) is a disease that seriously threatens human life and health. The aim of the study was to investigate the effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response, as well as the antioxidant capacity of ARDS. Eighty patients with ARDS treated in Yiwu Central Hospital from January, 2015 to December, 2016 were enrolled in the present study and divided into the observation (n=40) and control (n=40) groups, using a random number table.