Developing an orbitally shaken bioreactor featuring a square vessel wall with a large circular chamfer.

The impact of orbitally shaking bioreactors (OSRs) on the biopharmaceutical industry is becoming increasingly important. In the preliminary exploration of the orbitally shaking bioreactor performance, the vessel wall shape has a crucial influence on the mixing and mass transfer in the bioreactor. However, the shape of OSRs still maintains a cylindrical structure, significantly limiting the advantages of the orbital shaking mixing.

Anti-Asthma Effect of an Active Components Group from Decoction of and Its Chemical Composition Characterized by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry.

The decoction of is used as a traditional medicine for treatment of asthma in China with a long clinical history. The aim of the study was to investigate the anti-asthma activities of an active components group obtained from the decoction of in histamine and ovalubumin induced asthma guinea pigs. The experimental asthma model was established with spray of histamine and ovalbumin (OVA) followed by intragastric administration of extract and fractions.