Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities.

Tricyclic cytosines (tC and tC(O) frameworks) have emerged as a unique class of fluorescent nucleobase analogues that minimally perturb the structure of B-form DNA and that are not quenched in duplex nucleic acids. Systematic derivatization of these frameworks is a likely approach to improve on and diversify photophysical properties, but has not so far been examined. Synthetic methods were refined to improve on tolerance for electron-donating and electron-withdrawing groups, resulting in a series of eight new, fluorescent cytidine analogues.

The use of transcutaneous acupoint electrical stimulation for preventing nausea and vomiting after laparoscopic surgery.

Unlabelled: Nonpharmacologic techniques may be effective in preventing postoperative nausea and vomiting (PONV). This sham-controlled, double-blinded study was designed to examine the antiemetic efficacy of transcutaneous acupoint electrical stimulation (TAES) in a surgical population at high risk of developing PONV. We studied 221 outpatients undergoing laparoscopic cholecystectomy with a standardized general anesthetic technique in this randomized, multicenter trial.

Mandated human services restructuring: a case study in local collaboration from Colorado.

The Colorado State Legislature has undertaken an historic restructuring of human services ranging from child welfare, mental health, and nursing services to substance abuse prevention, institutionalization, and health care financing. Significant steps in this process include an overhaul of child welfare legislation, major revisions to legislation affecting group health insurance policies, and a restructuring of the state departments that provide human services. A Democratic Governor and a Republican-dominated legislature have worked together hand-in-hand, although not always harmoniously, in moving these changes forward.

Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group.

In a multicentre, randomized, double-blind, placebo-controlled dose-ranging study, 1030 patients undergoing outpatient surgery with general anaesthesia received i.v. dolasetron mesylate (12.

Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial.

Study Objectives: To compare repeat intravenous (i.v.) dosing of ondansetron 4 mg with placebo for the treatment of postoperative nausea and vomiting (PONV) in patients for whom prophylactic, preoperative ondansetron 4 mg i.

Reduced resource utilization in patients treated for postoperative nausea and vomiting with dolasetron mesylate. MCPR44 Study Group.

Study Objective: To compare the effect of four different increasing increasing intravenous (i.v.) doses of dolasetron mesylate (12.

Remifentanil versus propofol as adjuncts to regional anesthesia. Remifentanil 3010 Study Group.

Study Objective: To compare the safety and efficacy of remifentanil and propofol as adjuncts to regional anesthesia in patients undergoing orthopedic or urogenital surgery.

Design: Prospective, randomized study.

Setting: Multicenter university hospitals.

Prolonged surgery increases the likelihood of admission of scheduled ambulatory surgery patients.

Study Objective: To identify variables influencing the likelihood of unanticipated admission following scheduled ambulatory surgery.

Design: Retrospective case-controlled chart review study.

Setting: A large academic tertiary care hospital.

Propofol permits tracheal intubation but does not affect postoperative myalgias.

Study Objective: To determine the effect of propofol without succinylcholine on intubating conditions and postoperative myalgias in ambulatory surgical patients undergoing general anesthesia.

Design: Prospective, double-blind, randomized study.

Setting: Ambulatory surgery adult patients.

Surgical patients' attitudes regarding participation in clinical anesthesia research.

We designed a questionnaire to identify the factors influencing both day of admission surgery (DAS) and ambulatory (AMB) patients in their decision whether to participate in and give informed consent for clinical anesthesia research. On the day of surgery, 276 patients were approached to complete a questionnaire and a visual analog scale (VAS) to assess anxiety. The data collected were observational and are presented as percentages for each group (DAS and AMB).

Recovery advantages of regional anesthesia compared with general anesthesia: adult patients.

The data support but do not conclusively prove, that RA results in a superior recovery compared with GA. However, several questions need to be answered. Even though the patient may leave the hospital or surgicenter sooner after RA, how does the patient treat pain at home once the block has "worn off"? Since short-acting sedatives and opioids are so commonly used with RA, to what extent is recovery due to them and to what extent is recovery due to the RA alone? Many of the studies examining beneficial effects of RA have been poorly conducted, combining RA with GA and producing inconclusive results.

Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron.

Background: Postoperative nausea and vomiting following outpatient surgery can significantly delay discharge. This study evaluates the safety and efficacy of ondansetron (a new 5-HT3 antagonist) in the treatment of postoperative nausea and vomiting in patients following outpatient surgery.

Methods: Five hundred outpatient surgical patients (53 male and 447 female), receiving general endotracheal anesthesia, were studied at ten centers.

Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study.

The safety and efficacy of ondansetron were evaluated in the treatment of postoperative nausea and vomiting. Five hundred patients who experienced nausea or vomiting in the Post-Anaesthesia Care Unit within the first 2 h of recovery were randomized to receive either 1, 4, or 8 mg of ondansetron, or placebo. All patients had undergone ambulatory surgery with general endotracheal anaesthesia.

Attenuation of suxamethonium myalgias. Effect of midazolam and vecuronium.

We studied the incidence of fasciculations and postoperative myalgias in 100 female outpatients who had laparoscopy under thiopentone, N2O, isoflurane anaesthesia. Four groups of 20 patients each were pretreated with saline (group 1), tubocurarine 0.05 mg/kg (group 2), vecuronium 0.

A defasciculating dose of d-tubocurarine causes resistance to succinylcholine.

Forty-four patients, ASA physical status I or II, undergoing thiamylal, fentanyl, N2O/O2 anaesthesia were studied to determine the dose-response to succinylcholine (Sch) without prior defasciculation (24 pt - Group 1), or three minutes following d-tubocurarine (dTC), 0.043 mg.kg-1 (20 pt - Group 2).