EYA4 reduces chemosensitivity of osteosarcoma to doxorubicin through DNA damage repair.

Previous studies have demonstrated that Eyes Absent 4 (EYA4) influences the proliferation and migration of tumor cells. Notably, studies have established that EYA4 can also limit tumor sensitivity to chemotherapeutic agents. The objective of this study was to investigate the effect of EYA4 in conferring drug resistance in osteosarcoma (OS).

A new particle filter algorithm filtering motion artifact noise for clean electrocardiogram signals in wearable health monitoring system.

With the evolution of wearable systems, more and more people tend to wear wearable devices for health monitoring during sports. However, a large amount of motion artifact noise is introduced at this time, which is difficult to filter out due to its stochasticity. The amplitude and characteristics of motion artifact noise vary with changes in motion intensity.

Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury.

Neuroinflammation is associated with poor outcomes in patients with spinal cord injury (SCI). Recent studies have demonstrated that stimulator of interferon genes (Sting) plays a key role in inflammatory diseases. However, the role of Sting in SCI remains unclear.

Compression-Softening Bond Model for Non-Water Reactive Foaming Polyurethane Grouting Material.

In this study, the uniaxial compression and cyclic loading and unloading experiments were conducted on the non-water reactive foaming polyurethane (NRFP) grouting material with a density of 0.29 g/cm, and the microstructure was characterized using scanning electron microscope (SEM) method. Based on the uniaxial compression and SEM characterization results and the elastic-brittle-plastic assumption, a compression softening bond (CSB) model describing the mechanical behavior of micro-foam walls under compression was proposed, and it was assigned to the particle units in a particle flow code (PFC) model simulating the NRFP sample.

Efficacy and safety of pharmacologic therapies for prevention of osteoporotic vertebral fractures in postmenopausal women.

Background: There are many pharmaceutical interventions available to prevent osteoporotic vertebral fractures in postmenopausal women, but the efficacy and safety of these drugs are unknown. This study aimed to investigate the efficacy and safety of drugs in the prevention of osteoporotic vertebral fractures.

Methods: PubMed, Embase, and the Cochrane Library were comprehensively searched for randomized controlled trials (RCTs) published up to February 15, 2020, including postmenopausal women with osteoporosis.

Clinical study of Tongdu Shujin decoction in the treatment of ankylosing spondylitis with cold-dampness obstruction type: Study protocol for a randomized controlled trial.

Background: Ankylosing spondylitis (AS) has a high incidence, and severe cases can lead to spinal deformity and even joint fusion, which causes a huge burden on patients life, work and psychology. Tongdu Shujin decoction (TDSJ) has a definite effect in the treatment of ankylosing spondylitis, so we designed a randomized controlled trial to observe the efficacy of TDSJ in the treatment of AS, and to evaluate its safety.

Methods: In this randomized controlled trial, 80 eligible patients were randomly assigned in a 1:1 ratio to a treatment group TDSJ and a control group (celecoxib capsules in combination with thalidomide tablets) for 8 weeks.

Comparison of posterior decompression techniques and conventional laminectomy for lumbar spinal stenosis.

Objectives: To compare the efficacy of posterior decompression techniques with conventional laminectomy for lumbar spinal stenosis.

Methods: The Embase, PubMed, and Cochrane Library databases were searched with no language limitations from inception to January 13, 2022. The main outcomes were functional disability, perceived recovery, leg and back pain, complications.

Physical exercise improved muscle strength and pain on neck and shoulder in military pilots.

To evaluate the effects of physical exercise on neck and shoulder muscle strength and pain in military pilots. Embase, PubMed, and Cochrane Library databases were searched studies published up to April 1, 2022. Studies that met the screening criteria were included in the final meta-analysis.

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma.

Glioblastoma (GBM) is the most malignant tumor of the central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role in the treatment of GBM. However, major impediments to effective treatment are postoperative tumor recurrence and acquired resistance to chemoradiotherapy.

Decompression alone or decompression and fusion in degenerative lumbar spondylolisthesis.

Background: Clinically, there are substantive practice variations in surgical management of degenerative lumbar spondylolisthesis. We aimed at evaluating whether decompression alone outcomes for patients with degenerative lumbar spondylolisthesis are comparable to those of decompression with fusion.

Methods: In this meta-analysis, the Embase, PubMed, and Cochrane Library databases were searched from inception to February 16th, 2022.

Oblique Lateral Interbody Fusion vs. Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Spinal Stenosis: A Retrospective Cohort Study.

Background: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an effective surgical option for lumbar spinal stenosis (LSS) with spondylolisthesis. However, few studies have discussed oblique lateral interbody fusion (OLIF) with MIS-TLIF.

Objective: To evaluate postoperative improvements, complications, and reoperation rates between patients with LSS undergoing OLIF or MIS-TLIF.

A strong anti-noise segmentation algorithm based on variational mode decomposition and multi-wavelet for wearable heart sound acquisition system.

Wearable devices have now been widely used in the acquisition and measurement of heart sound signals with good effect. However, the wearable heart sound acquisition system (WHSAS) will face more noise compared with the traditional system, such as Gaussian white noise, powerline interference, colored noise, motion artifact noise, and lung sound noise, because users often wear these devices for running, walking, jumping or various strong noise occasions. In a strong noisy environment, WHSAS needs a high-precision segmentation algorithm.

Exploring the Pharmacological Potential of Metformin for Neurodegenerative Diseases.

Metformin, one of the first-line of hypoglycemic drugs, has cardioprotective, anti-inflammatory and anticancer activities, in addition to its proven hypoglycemic effects. Furthermore, the preventive and therapeutic potential of metformin for neurodegenerative diseases has become a topic of concern. Increasing research suggests that metformin can prevent the progression of neurodegenerative diseases.

Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma.

Background: Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated.

Methods: Genome-wide CRISPR screening combined with transcriptomic sequencing were used to identify the critical genes of doxorubicin resistance. Analysis of clinical samples and datasets, and in vitro and in vivo experiments (including CCK-8, apoptosis, western blot, qRT-PCR and mouse models) were applied to confirm the function of these genes.

Algorithms for accurate spectrum measurement of high-resolution analog-to-digital converter with non-coherent sampling.

In Analog-to-Digital Converter (ADC) spectrum measurement, the realization of coherent sampling is difficult to implement, which has always been one of the bottlenecks. When coherent sampling is not available, researchers have been looking for some precise methods to test high-resolution ADCs under non-coherent sampling conditions. This study introduces two algorithms to, respectively, resolve harmonic distortion and ADC amplitude clipping problems with non-coherent sampling based on the idea of replacement.

LncRNA promotes the malignant progression of colorectal cancer by regulating the miR-214-5p-JAG1 axis.

Background: Long non-coding RNAs (lncRNAs) have recently been found to be vital regulators of various cancers, including colorectal cancer (CRC). It has been previously reported that the dysregulated expression of lncRNA Five prime to Xist () is involved in carcinogenesis. However, the role of lncRNA in the progression of CRC is still unclear.

Therapeutic Effect of Large Channel Endoscopic Decompression in Lumbar Spinal Stenosis.

Percutaneous endoscopic decompression (PED) is a minimally invasive surgical technique that is now used for not only disc herniation but also lumbar spinal stenosis (LSS). However, few studies have reported endoscopic surgery for LSS. Therefore, we conducted this study to evaluate the outcomes and safety of large channel endoscopic decompression.

Comparison of Different Operative Approaches for Lumbar Disc Herniation: A Network Meta-Analysis and Systematic Review.

Background: New approaches and technologies can be beneficial for patients but also bring corresponding complications. Traditional pairwise meta-analyses cannot be used to comprehensively rank all surgical approaches.

Objectives: The purpose of this systematic review and network meta-analysis (NMA) was to compare the outcomes of different surgical approaches for lumbar disc herniation (LDH).

Management for lumbar spinal stenosis: Protocol for a network meta-analysis and systematic review.

Introduction: Lumbar spinal stenosis (LSS) is caused by structural changes of the spine, which lead to several severe symptoms, including back pain, leg pain, numbness and tingling in the legs, as well as reduced physical function. However, there is little evidence suggesting whether a patient with LSS should be treated with surgery. If surgery is recommended, which type of surgery benefits the patient most? To answer these questions, we will conduct a network meta-analysis and a systematic review to compare surgical and nonsurgical interventions in terms of efficacy as well as safety in adult patients with LSS.

Management for lumbar spinal stenosis: A network meta-analysis and systematic review.

Background: Conventional paired meta-analyses have shown inconsistent results regarding the safety and efficacy of different interventions.

Objective: To perform a network meta-analysis (NMA) and systematic review based on randomized controlled trials (RCTs) evaluating the efficacies of different interventions for lumbar spinal stenosis (LSS).

Methods: We searched PubMed, Embase, Cochrane Library, Web of Science, and major scientific websites from inception to October 10, 2019, for randomized controlled trials comparing the nine most commonly used interventions for LSS.

Coflex interspinous process dynamic stabilization for lumbar spinal stenosis: Long-term follow-up.

Objective: To evaluate the long-term efficacy of Coflex dynamic stabilization device in the treatment of lumbar spinal stenosis.

Methods: The clinical and imaging data of 73 patients undergoing Coflex dynamic stabilization surgery from July 2008 to June 2012 were retrospectively analyzed. All patients had a minimum of 8 years of follow-up.

Preparation and Characterization of Emulsion-based Peony Seed Oil Microcapsule.

Microcapsules were constructed with starch sodium octenyl succinate (SSOS), β-cyclodextrin (β-CD), and pectin walls and peony seed oil cores. A rheological phenomenon occurred in which the emulsion initially behaved like a shear-thickening fluid and then a shear-thinning fluid within a shear range. The emulsion exhibited good stability under low amplitude stress; however, as amplitude increased the concentration of pectin played an important role in maintaining the stability of the emulsion system.

Recombinant Expression of Outer Membrane Phospholipase A (A1) in and Immobilization With Graphene Oxide-Based FeO Nanoparticles for Rapeseed Oil Degumming.

Enzymatic degumming is an effective approach to produce nutritional, safe, and healthy refined oil. However, the high cost and low efficiency of phospholipase limit the application of enzymatic degumming. In this study, an 879 bp outer membrane phospholipase A (A1) (OM-PLA1) gene encoding 292 amino acid residues was isolated from the genome of .

Dispersion of Multi-Walled Carbon Nanotubes Stabilized by Humic Acid in Sustainable Cement Composites.

Multi-walled carbon nanotubes (MWCNTs) are promising nanoreinforcing materials for cement-based composites due to their superior material properties. Dispersion of MWCNTs is key for achieving the most effective way of enhancing efficiency, which is challenging in an alkaline cementitious environment. In this study, humic acid (HA) was used to stabilize the degree of dispersion of MWCNTs in an alkaline environment.