Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis.

Retinal ischemia‒reperfusion (I/R) injury can cause significant damage to human retinal neurons, greatly compromising their functions. Existing interventions have been proven to have little effect. Ferroptosis is a newly discovered type of programmed cell death that has been found to be involved in the process of ischemia‒reperfusion in multiple organs throughout the body.

Fulvic acid degradation in Fenton-like system with bimetallic magnetic carbon aerogel Cu-Fe@CS as catalyst: Response surface optimization, kinetic and mechanism.

In this study, Cu-Fe bimetallic magnetic chitosan carbon aerogel catalyst (Cu-Fe@CS) was prepared by the sol-gel method to degrade Fulvic acid (FA) in Fenton-like system. Degradation experiment results showed bimetallic catalyst Cu-Fe@CS can degrade more FA than monometallic catalysts (Cu@CS and Fe@CS) due to the synergistic effect between the copper and iron. Plackett Buiman (PB) design showed that pH and temperature exhibited significant influence on FA degradation.

Optimization of heterogeneous Fenton-like process with Cu-Fe@CTS as catalyst for degradation of organic matter in leachate concentrate and degradation mechanism research.

The heterogeneous Fenton-like process with bimetallic chelated magnetic chitosan aerogel (Cu-Fe@CTS) as catalyst was applied to treat pre-coagulated leachate nanofiltration concentrate. The process conditions were optimized by Box-Behnken Design (BBD) and the maximum UV removal reached 96.06% under the conditions of temperature 87.

Huoxue-Tongluo-Lishui-Decoction is visual-protective against retinal ischemia-reperfusion injury.

Retinal ischemia reperfusion injury (IRI) is a leading cause of visual impairment or blindness, and an effective way to prevent the visual loss needs to be developed. Although decades of clinical application of Huoxue-Tongluo-Lishui-Decoction (HTLD) has demonstrated its reliable clinical efficacy against retinal IRI, no convincing randomized controlled trials were conducted in humans or animals, and the associated mechanism still needs to be explored. To confirm the protective effect of HTLD against retinal IRI and to explore its underlying mechanisms, a standard retinal IRI animal model, randomized controlled trials, objective evaluation and examination methods were adopted in this study.

Reversible Transformation between Amorphous and Crystalline States of Unsaturated Polyesters by Cis-Trans Isomerization.

An aliphatic polyester has been prepared from ethylene oxide and maleic anhydride that undergoes reversible transformation between amorphous (T =18 °C) and crystalline (T =124 °C) states through cis-trans isomerization of the C=C bonds in the polymer backbone without any change in either the molecular weight or dispersity of the polymer. A similar transformation was also observed in chiral unsaturated polyesters formed from enantiopure terminal epoxides, such as epichlorohydrin, phenyl glycidyl ether, and (2,3-epoxypropyl)benzene. These unsaturated polyesters with 100 % E-configuration in the crystalline state were prepared by quantitative isomerization of their Z-configuration analogues in the presence of a catalytic amount of diethylamine, while in the presence of benzophenone, irradiation with 365 nm UV light resulted in the transformation of about 30 % trans-alkene to cis-maleate form, thereby affording amorphous polyesters.

CareerVis: Hierarchical Visualization of Career Pathway Data.

We present our CareerVis system, an interactive visualization tool to aid career education for high school and freshman college students. In additional to its practical use, we believe our design approach has potential to inspire the design community to develop simple visualizations that convey complex information to novice users.

Highly efficient conversion of CO to cyclic carbonates with a binary catalyst system in a microreactor: intensification of "electrophile-nucleophile" synergistic effect.

An intensification of the "electrophile-nucleophile" synergistic effect was achieved in a microreactor for the coupling reaction of CO and epoxides mediated by the binary Al complex/ternary ammonium salt catalyst system. The microreactor technology is proven to be a powerful tool for the preparation of cyclic carbonates with an improved reaction rate and a wide substrate scope.