CTBP2 contributes to cisplatin resistance in lung adenocarcinoma by inhibiting generation of reactive oxygen species.

Background: Cisplatin (CP) is commonly used for the initial treatment of lung adenocarcinoma (LUAD). Resistance to CP has long been recognized as a significant obstacle to achieving improved therapeutic outcomes. Nevertheless, the intricate molecular mechanisms underlying the phenomenon remain incompletely understood.

Constructing of efficient interface solar evaporator: In-situ colloid foaming strategy for solar desalination and visible light response sewage purification.

The shortage of drinking water has become a global problem, coastal cities can make full use of abundant seawater resources by desalination technology to ease the contradiction between supply and demand. However, fossil energy consumption contradicts the goal of reducing carbon dioxide emissions. Currently, researchers favor interfacial solar desalination devices relying only on clean solar energy.

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity.

Carbon dots (CDs) have been widely used as antimicrobials due to their active surface, but some CDs suffer instability. Therefore, the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process.

Engineering a bacterial sialyltransferase for di-sialylation of a therapeutic antibody.

Terminal α-2,6-sialylation of N-glycans is a humanized glycosylation that affects the properties and efficacy of therapeutic glycoproteins. Fc di-sialylation (a biantennary N-glycan with two α-2,6-linked sialic acids) of IgG antibodies imparts them with enhanced anti-inflammatory activity and other roles. However, the microheterogeneity of N-glycoforms presents a challenge for therapeutic development.

Tat peptide-mediated soluble expression of the membrane protein LSECtin-CRD in Escherichia coli.

The human liver and lymph node sinusoidal endothelial cell C-type lectin (hLSECtin), a type II integral membrane protein, containing a Ca(2+)-dependent carbohydrate recognition domain (CRD), has a well-established biological activity, yet its three-dimensional structure is unknown due to low expression yields and aggregation into inclusion bodies. Previous study has demonstrated that the HIV-1 virus-encoded Tat peptide ('YGRKKRRQRRR') can increase the yields and the solubility of heterologous proteins. However, whether the Tat peptide could promote the high-yield and soluble expression of membrane proteins in Escherichia coli is not known.

Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma.

Background: African American patients disproportionately experience uncontrolled asthma. Treatment with an inhaled corticosteroid (ICS) is considered first-line therapy for persistent asthma.

Objective: We sought to determine the degree to which African American patients respond to ICS medication and whether the level of response is influenced by other factors, including genetic ancestry.

A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma.

Background: Inhaled corticosteroid (ICS) nonadherence is common among patients with asthma; however, interventions to improve adherence have often been complex and not easily applied to large patient populations.

Objective: To assess the effect of supplying patient adherence information to primary care providers.

Methods: Patients and providers were members of a health system serving southeast Michigan.

[Anticancer effects of a novel indolinone compound in nasopharyngeal carcinoma cells].

Objective: To develop novel targeted anticancer medicines for effective treatment of nasopharyngeal carcinoma (NPC), a prevalent malignant disease in southern China and southeast Asia.

Methods: CNE cells were treated with a novel indolinone IF239 synthesized by our research group. Cell viability was determined by the acid phosphatase assay (APA).

Race-ethnic differences in factors associated with inhaled steroid adherence among adults with asthma.

Rationale: Adherence to inhaled corticosteroid (ICS) medication is known to be low overall, but tends to be lower among African-American patients when compared with white patients.

Objectives: To understand the factors that contribute to ICS adherence among African-American and white adults with asthma.

Methods: Eligible individuals had a prior diagnosis of asthma, one or more ICS prescriptions, and were members of a large health maintenance organization in southeast Michigan.

Improving asthma care through recertification: a cluster randomized trial.

Background: As part of recertification, the American Board of Internal Medicine requires its diplomats to complete at least 1 practice improvement module (PIM). We assessed whether completing an asthma-specific PIM resulted in improved patient outcomes.

Methods: Practices were the unit of randomization in this cluster randomized trial.

Patients with asthma who do not fill their inhaled corticosteroids: a study of primary nonadherence.

Background: Adherence to inhaled corticosteroids (ICSs) is known to be poor among patients with asthma; however, little is known about patients who do not fill their ICS prescriptions (ie, primary nonadherence).

Objective: To estimate rates of primary nonadherence and to explore associated factors.

Methods: The study population was members of a large health maintenance organization in southeast Michigan who met the following criteria: age 5 to 56 years; previous diagnosis of asthma; at least 1 electronic prescription for an ICS between February 17, 2005, and June 1, 2006; and at least 3 months follow-up after the ICS prescription.