Publications by authors named "Mingqing Kuang"
Background: Type 2 diabetes mellitus (T2DM) is a global disease with growing prevalence that is difficult to cure. Rosa roxburghii Tratt is an edible and medicinal plant, and modern pharmacological studies have shown that it has potential anti-diabetic activity. This is the first study to explore the active components and potential mechanisms of Rosa roxburghii Tratt fruit for treating T2DM based on UPLC-Q-Exactive Orbitrap/MS and network pharmacology.
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- The study focuses on Dorsal, an NF-κB family transcription factor in the crab species Scylla paramamosain, which is crucial for immune regulation and shows strong similarities to Dorsal proteins in other crustaceans.
- SpDorsal is primarily expressed in hemocytes and its levels change significantly upon immune stimulation, particularly when exposed to Gram-positive bacteria like Staphylococcus aureus.
- Inhibition of SpDorsal through RNA interference led to higher mortality rates in crabs infected with S. aureus, suggesting its key role in the immune response specifically against Gram-positive bacterial infections.