Publications by authors named "Mingpan Yan"
A simple and efficient methodology for the synthesis of large sterically hindered triarylamines in a single step was developed. A direct ,-diarylation of 8-aminoquinoline with sterically hindered bromides, making use of inexpensive nickel as a catalyst and simple sodium salt as a base, gives the products in good to excellent yields. Various bromides and substituted 8-aminoquinolines are tolerated.
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- The reaction involves trifluoroacetyl amides reacting with Grignard reagents, replacing the CF group with various alkyl or aryl groups.
- A range of functional groups and halogens like F, Cl, and Br are compatible in this process.
- The reaction likely goes through an isocyanate intermediate or a combination of alkoxide and amide intermediates.