Publications by authors named "Mingna Zhang"
Article Synopsis
- mRNA neoantigen cancer vaccines show potential in immunotherapy by stimulating specific T cell responses but face challenges like poor neoantigen prediction and low delivery efficiency.
- Researchers developed a lipopolyplex (LPP)-formulated mRNA cancer vaccine that effectively triggered strong CD8 T cell responses in mouse models, significantly suppressing tumor growth.
- The LPP vaccine showed promise in patients, inducing T cell responses and clinical effects, suggesting it warrants further clinical trials for cancer treatment.
Therapeutic cancer vaccines: advancements, challenges, and prospects.
Signal Transduct Target Ther
December 2023
With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over the past decades. Recently, therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens, including tumor-associated antigens and tumor-specific antigens. The objective was to amplify and diversify the intrinsic repertoire of tumor-specific T cells.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on liver cancer and the role of leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) tumor-initiating cells (TICs) and cancer-associated fibroblasts (CAFs) in tumor development.
- Researchers created a three-dimensional (3D) organoid model combining LGR5-expressing TICs and CAFs to examine their interactions, overcoming limitations of previous models.
- Successful establishment of the co-culture organoid model allows for further investigation into how CAFs influence LGR5 TICs, potentially impacting tumor formation and metastasis in liver cancer.
Designing a Needs-Oriented Psychological Intervention for Chinese Women Undergoing an Abortion.
Int J Environ Res Public Health
December 2022
Accessing good quality abortion care is a fundamental human right and contributes to achieving Sustainable Development Goals. However, well-designed abortion care that meets women's needs is limited. This study aims to systematically develop an intervention to promote the psychological well-being of Chinese women undergoing an abortion.
View Article and Find Full Text PDFBackground: A high tendency of intention to leave has been noted for nurses in China. The nursing profession is currently unstable.
Methods: A sample of 51406 nurses from 311 hospitals in China who completed the self-administered questionnaire online was recruited via the China Nursing Association by email and phone using a simple random sampling method.
[Pulmonary hypertension in chronic obstructive pulmonary disease can not be ignored].
Zhonghua Jie He He Hu Xi Za Zhi
April 2013
Legumain: a biomarker for diagnosis and prognosis of human ovarian cancer.
J Cell Biochem
August 2012
Legumain is a member of the asparaginyl endopeptidase family that is over-expressed in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs). Here, we demonstrate that elevated expression of legumain in ovarian cancer by a proteomic approach using isobaric tags for relative and absolute quantification (iTRAQ) followed by liquid chromatography-mass spectrometry (LC-MS/MS). To investigate the relationship between legumain expression and ovarian cancer development, we tested legumain expression in malignant human ovarian tumors (n = 60), borderline ovarian tumors (n = 20), benign ovarian tumors (n = 20), and normal ovary samples (n = 20) using immunohistochemical assay (IHC).
View Article and Find Full Text PDF