Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus.

SARS-CoV-2 infection poses a major threat to public health, and understanding the mechanism of viral replication and virion release would help identify therapeutic targets and effective drugs for combating the virus. Herein, we identified E3 ubiquitin-protein ligase Itchy homolog (ITCH) as a central regulator of SARS-CoV-2 at multiple steps and processes. ITCH enhances the ubiquitination of viral envelope and membrane proteins and mutual interactions of structural proteins, thereby aiding in virion assembly.

Multiplex Biomimetic SLIPS With Super-Lubricity to Multiphase Matters.

In recent years, slippery liquid infused porous surfaces (SLIPS) renowned for their exceptional liquid repellency and anti-fouling properties, have garnered considerable attention. However, the instability of both structural integrity and the oil film severely restricts their practical applications. This study is inspired by superwetting biological surfaces, such as fish scales, seashells, and Nepenthes, to design and fabricate a multiplex biomimetic and robust lubricant-infused textured surface (LITMS) using laser-coating composite processing technology.

Structure-based design and screening of hydrogel copolymer/FeO composite microspheres for magnetic solid phase extraction of bisphenol A from aqueous samples.

It is of great significance to monitor bisphenol A (BPA) in the environment because of its potential environmental and health risks. However, the detection of trace or ultratrace BPA in complicated environmental samples is challenging due to the relatively low affinity and poor selectivity of existing adsorbents used in sample pretreatment. Herein, we report a high-affinity, low environment-dependent and strong interference-resistant abiotic affinity ligand, a N-methacryloyl-l-lysine-NH (MLys)-based hydrogel copolymer (HP 17) screened from a small focused polymer library engineered by incorporating various combinations and ratios of candidate functional monomers.

Interactions between cetaceans and aquatic debris in Chinese waters: A study based on social media data.

Aquatic debris is considered a major threat to cetaceans. China is subject to severe marine plastic waste that may threaten cetaceans. However, the impact of aquatic debris on cetaceans in Chinese waters has remained poorly studied.

TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy.

Background: Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression and autoimmune disease activity. As B cell differentiation and autoantibody production exacerbate autoimmune disease, the signaling pathways involved in these processes were explored.

The moderation effect of GSTM1/GSTT1 gene polymorphisms on the association of sperm mitochondrial DNA copy number and sperm mobility.

Oxidative stress (OS) is believed to be a significant factor in the decline of semen quality, with mitochondrial DNA copy number (mtDNAcn) serving as a sensitive biomarker for both semen quality and mitochondrial dysfunction resulting from oxidative stress. While glutathione S-transferases (GSTs) are commonly known as 'antioxidant' enzymes, there is ongoing debate regarding the relationship between GST genotypes and semen quality. In a study involving 568 male volunteers from the outpatient department of Puyang Reproductive Medicine Center, sperm mtDNAcn, semen quality, and GSTM1/GSTT1 genotypes were analyzed to investigate the potential link between GSTM1/GSTT1 gene variations and semen quality, as well as the impact of GSTs gene variations on the connection between sperm mtDNAcn and semen quality.

Dysregulation of lncRNA TFAP2A-AS1 is involved in the pathogenesis of pulpitis by the regulation of microRNA-32-5p.

Objective: This study was designed to evaluate TFAP2A-AS1 expression in the dental pulp of teeth with or without pulpitis and to determine the function of TFAP2A-AS1 in pulp cells.

Methods: GSE92681 was analyzed to filter out differentially expressed lncRNAs. Pulp samples from teeth with pulpitis and healthy teeth (control) were examined using real-time (RT) quantitative polymerase chain reaction (qPCR).

Navigating the Landscape of Coronary Microvascular Research: Trends, Triumphs, and Challenges Ahead.

Coronary microvascular dysfunction (CMD) refers to structural and functional abnormalities of the microcirculation that impair myocardial perfusion. CMD plays a pivotal role in numerous cardiovascular diseases, including myocardial ischemia with non-obstructive coronary arteries, heart failure, and acute coronary syndromes. This review summarizes recent advances in CMD pathophysiology, assessment, and treatment strategies, as well as ongoing challenges and future research directions.

Comprehensive scRNA-seq analysis to identify new markers of M2 macrophages for predicting the prognosis of prostate cancer.

Background: Prostate cancer (PCa) has become the highest incidence of malignant tumor among men in the world. Tumor microenvironment (TME) is necessary for tumor growth. M2 macrophages play an important role in many solid tumors.

Impact of several sludge dewatering conditioners on municipal sludge pyrolysis properties, kinetics, by-products, and environmental risk assessment.

The pyrolysis characteristics of four different types of conditioned sludge were ascertained, and PAM, CaO, KFeO, and KFeO-CaO-PAM (KCP) conditioners were employed as sludge dewatering conditioners. The sludge pyrolysis reaction's activation energy (E) dropped with the addition of four conditioners. CaO, PAM, KCP, and KFeO were the sequences of E needed for the pyrolysis of four different types of conditioned sludge.

Regulation of ginseng adventitious root growth in Panax ginseng by the miR156-targeted PgSPL24-09 transcription factors.

MicroRNA (miRNA) is a class of non-coding endogenous small-molecule, single-stranded RNAs, and it is involved in post-transcriptional gene expression regulation in plants and plays an important role in plant growth and development. Among them, miRNA156 regulates members of target SPL gene family and thus participates in plant growth and development, hormonal response and adversity stress. However, it has not been reported in ginseng.

Individual and combined effects of famine exposure and obesity parameters on type 2 diabetes in middle-aged and older adults: A population-based cross-sectional study.

Malnutrition early in life may have adverse effects on health later in life. The relationship between malnutrition and obesity parameters (body mass index [BMI] and waist circumference [WC]) and type 2 diabetes is inconsistent. This study aimed to identify the effects of famine exposure and obesity parameters on type 2 diabetes individually or in combination among middle-aged and older adults in China.

Evaluation of the inhibitory effects of sitamaquine on Babesia infections.

The treatment strategies for either human or animal babesiosis have been established and used for many years. With the rising indications of drug resistance and adverse side effects, finding effective and alternative therapies is urgently needed. Sitamaquine (SQ) is an 8-aminoquinoline that was first synthesized as a part of the collaborative anti-malarial program that led to primaquine.

Green light all the way: Triple modification synergistic modification effect to enhance the photoelectrochemical water oxidation performance of BiVO photoanode.

The recombination of photogenerated electron-hole pairs of the photoanode seriously impairs the application of bismuth vanadate (BiVO) in photoelectrochemical water splitting. To address this issue, we prepared a Yb:BiVO/CoO/FeOOH composite photoanode by employing drop-casting and soaking methods to attach CoO/FeOOH cocatalysts to the surface of ytterbium-doped BiVO. The prepared Yb:BiVO/CoO/FeOOH photoanode demonstrates a high photocurrent density of 4.