Adaptation of a HIV Prevention Mobile App for Transmasculine People: A Pilot Acceptability and Feasibility Study.

Purpose: Using a community-engaged approach, we adapted a human immunodeficiency virus (HIV) prevention smartphone app, Transpire, to meet the HIV and sexually transmitted infection (STI) prevention needs of transgender men and other transmasculine people. We conducted a pilot study to assess the feasibility and acceptability of the app among participants in two cities in the southeastern United States.

Methods: Participants were recruited online and through community partners.

Preferences for and Experiences of an HIV-Prevention Mobile App Designed for Transmasculine People: Pilot Feasibility Trial and Qualitative Investigation.

Background: Transmasculine people are at risk for HIV; yet few HIV prevention interventions have been developed for this population. We adapted an existing HIV prevention smartphone app for cisgender men who have sex with men to meet the sexual health needs of transmasculine people.

Objective: This study aims to assess the acceptability of the adapted app, Transpire, among transmasculine people living in Atlanta, Georgia, and Washington, DC, via in-depth interviews of participants in a pilot feasibility trial.

Carbon and nitrogen footprint of different peanut rotation systems in Hubei Province, China.

Clarifying carbon and nitrogen emissions of different peanut rotation planting system can provide an effective reference to achieve high yield, high efficiency, and low carbon and nitrogen emissions. Based on field surveys on agricultural inputs and field managements, we calculated the carbon footprint and nitrogen footprint of three planting modes (rape-peanut rotation, wheat-peanut rotation and peanut monoculture) in Huanggang, Hubei Province. The results showed that compared with wheat-peanut rotation, carbon emission per unit area of rape-peanut rotation decreased by 7.

Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH.

Phenylketonuria is an inborn error of metabolism caused by loss of function of the liver-expressed enzyme phenylalanine hydroxylase and is characterized by elevated systemic phenylalanine levels that are neurotoxic. Current therapies do not address the underlying genetic disease or restore the natural metabolic pathway resulting in the conversion of phenylalanine to tyrosine. A family of hepatotropic clade F adeno-associated viruses (AAVs) was isolated from human CD34 hematopoietic stem cells (HSCs) and one (AAVHSC15) was utilized to deliver a vector to correct the phenylketonuria phenotype in Pah mice.

Priming With the Green Leaf Volatile (Z)-3-Hexeny-1-yl Acetate Enhances Salinity Stress Tolerance in Peanut ( L.) Seedlings.

Green leaf volatiles play vital roles in plant biotic stress; however, their functions in plant responses to abiotic stress have not been determined. The aim of this study was to investigate the possible role of (Z)-3-hexeny-1-yl acetate (Z-3-HAC), a kind of green leaf volatile, in alleviating the salinity stress of peanut () seedlings and the underlying physiological mechanisms governing this effect. One salt-sensitive and one salt-tolerant peanut genotype were primed with 200 μM Z-3-HAC at the 4-week-old stage before they were exposed to salinity stress.

Contribution of root uptake to cadmium accumulation in two peanut cultivars: evidence from a split-column soil experiment.

Cadmium (Cd) accumulation and internal Cd translocation in the peanut (Arachis hypogaea L.) are highly related to root uptake, which may largely depend on the cultivar variation and the depth of the Cd-contaminated soil. A split-column soil experiment was conducted using two common Chinese peanut cultivars (Huayu-20 and Huayu-23) known to relocate Cd to different tissues.

[Effects of root cutting under different seedling conditions on root system distribution and senescence character of peanut].

The effects of root cutting on root system distribution and senescence character of peanut (Arachis hypogaea) under different seedling conditions were investigated by using the box culture method. The results showed that, with three types of peanut seedlings, including overgrowing, strong and week seedlings, root cutting all first restricted and then promoted the root system growth, especially promoted the root growth to deep soil. This effect was stronger on the overgrowing and strong seedlings, while relatively weaker on the weak seedlings.

[Effects of light quality on photosynthetic pigment contents and photosynthetic characteristics of peanut seedling leaves].

This study explored the effects of different light quality on photosynthetic pigment contents and photosynthetic characteristics of peanut (Qinhua 6) seedling leaves. The results showed that, compared with natural light, blue light (445-470 nm) could significantly improve the specific leaf area (SLA), chlorophyll a/b value and carotenoid content of peanut seedlings. Meanwhile, the net photosynthetic rate, stomatal conductance, and transpiration rate were higher, the intercellular CO2 content was lower, and the photosynthetic efficiency was improved significantly under blue light.

[Effects of different cultivation modes on the leaf photosynthetic characteristics and yield of summer-sowing peanut].

Taking the Arachis hypogaea cv. 'Qinghua 7' as test material, a field experiment was conducted to study the effects of different cultivation modes on the leaf photosynthetic characteristics and yield of summer-sowing peanut after wheat harvest. As compared with conventional cultivation mode, high-yield protective cultivation mode promoted the leaf growth, significantly improved the leaf area index (LAI), and maintained a longer time of high LAI and chlorophyll content.

[Physiological responses of different peanut (Arachis hypogaea L.) varieties to cadmium stress].

To have a deep understanding on the mechanisms of cadmium (Cd) toxicity on peanut plants is of theoretical and practical significances for the selection and utilization of Cd-resistant peanut germ plasm resources. With fourteen peanut varieties as test materials and taking the chlorophyll content of functional leaves, malondialdehyde (MDA) content and cell membrane permeability of roots and leaves, and oxidative vitality of roots at flowering stage as test physiological parameters, a sand culture experiment was conducted in an artificial climate chamber to investigate the physiological responses of different peanut varieties to six levels of Cd stress. The results showed that within the range of 0-60 mg Cd x L(-1) addition, the chlorophyll content of functional leaves and the oxidative vitality of roots decreased significantly with increasing Cd addition, while the MDA content and cell membrane permeability of leaves and roots were in adverse.

Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.

Vitamin B12 deficiency may be induced by long-term use of metformin, which may in turn lead to hyperhomocysteinemia. Thus, hyperhomocysteinemia may increase the risk of vascular thrombosis in diabetic patients, when metformin is used and a homozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation is present. We report a 65-year-old Taiwanese diabetic woman who was treated with metformin for 6 years and who had suffered from swelling of the left lower extremity for 3 months.

[The effects of nitrogenous fertilizer on carbon metabolism characteristics of Glehnia littoralis].

The effects of different nitrogenous fertilizer on carbon metabolism in Glehnia littoralis were studied under the field condition. The results showed that the Sucrose Phosphat Synthase (SPS) activities and the content of soluble sugar in leaves showed the pattern of single peak curve during the growth period, and both highest level were similary appeared in the middle stage. The suitable rate of nitrogenous fertilizer can improve the SPS activities, the content of soluble sugar, the root Sucrose Synthase (SS) activities, and also kept low level of leaves soluble sugar in harvest.

The ERK/MAPK pathway regulates the activity of the human tissue factor pathway inhibitor-2 promoter.

Human tissue factor pathway inhibitor-2 (hTFPI-2) is a 32-kDa serine protease inhibitor that is associated with the extracellular matrix. hTFPI-2 inhibits several extracellular matrix-degrading serine proteases and may play a role in tumor invasion and metastasis. To study the signal transduction pathway that leads to the activation of the hTFPI-2, we cloned the potential promoter region of this gene adjacent to a heterologous luciferase reporter gene.