Tactile Sensing and Rendering Patch with Dynamic and Static Sensing and Haptic Feedback for Immersive Communication.

Wearable human-machine interface (HMI) with bidirectional and multimodal tactile information exchange is of paramount importance in teleoperation by providing more intuitive data interpretation and delivery of tactilely related signals. However, the current sensing and feedback devices still lack enough integration and modalities. Here, we present a Tactile Sensing and Rendering Patch (TSRP) that is made of a customized expandable array which consists of a piezoelectric sensing and feedback unit fused with an elastomeric triboelectric multidimensional sensor and its inner pneumatic feedback structure.

Intelligent Cubic-Designed Piezoelectric Node (iCUPE) with Simultaneous Sensing and Energy Harvesting Ability toward Self-Sustained Artificial Intelligence of Things (AIoT).

The evolution of artificial intelligence of things (AIoT) drastically facilitates the development of a smart city comprehensive perception and seamless communication. As a foundation, various AIoT nodes are experiencing low integration and poor sustainability issues. Herein, a cubic-designed intelligent piezoelectric AIoT node iCUPE is presented, which integrates a high-performance energy harvesting and self-powered sensing module a micromachined lead zirconate titanate (PZT) thick-film-based high-frequency (HF)-piezoelectric generator (PEG) and poly(vinylidene fluoride--trifluoroethylene) (P(VDF-TrFE)) nanofiber thin-film-based low-frequency (LF)-PEGs, respectively.

Analysis of Sequential Micromixing Driven by Sinusoidally Shaped Induced-Charge Electroosmotic Flow.

Multi-fluid micromixing, which has rarely been explored, typically represents a highly sought-after technique in on-chip biochemical and biomedical assays. Herein, we propose a novel micromixing approach utilizing induced-charge electroosmosis (ICEO) to implement multicomplex mixing between parallel streams. The variations of ICEO microvortices above a sinusoidally shaped floating electrode (SSFE) are first investigated to better understand the microvortex development and the resultant mixing process within a confined channel.

Augmented tactile-perception and haptic-feedback rings as human-machine interfaces aiming for immersive interactions.

Advancements of virtual reality technology pave the way for developing wearable devices to enable somatosensory sensation, which can bring more comprehensive perception and feedback in the metaverse-based virtual society. Here, we propose augmented tactile-perception and haptic-feedback rings with multimodal sensing and feedback capabilities. This highly integrated ring consists of triboelectric and pyroelectric sensors for tactile and temperature perception, and vibrators and nichrome heaters for vibro- and thermo-haptic feedback.

Soft Modular Glove with Multimodal Sensing and Augmented Haptic Feedback Enabled by Materials' Multifunctionalities.

Immersive communications rely on smart perception based on diversified and augmented sensing and feedback technologies. However, the increasing of functional components also raises the issue of increased system complexity. Here, we propose a modular soft glove with multimodal sensing and feedback functions by exploring and utilizing the multiple properties of glove materials.

FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia.

Synapse loss and memory decline are the primary features of neurodegenerative dementia. However, the molecular underpinnings that drive memory loss remain largely unknown. Here, we report that FAM69C is a kinase critically involved in neurodegenerative dementia.

RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis.

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, with a prevalence of 25% worldwide. However, the underlying molecular mechanism involved in the development and progression of the NAFLD spectrum remains unclear. Single-stranded DNA-binding protein replication protein A1 (RPA1) participates in DNA replication, recombination, and damage repair.

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

The ovarian-tumor-domain-containing deubiquitinases (OTUDs) block ubiquitin-dependent protein degradation and are involved in diverse signaling pathways. We discovered a rare OTUD3 c.863G>A mutation in a family with an early age of onset of diabetes.

PTENα is responsible for protection of brain against oxidative stress during aging.

Neural cells are continuously subjected to oxidative stress arising from electrochemical activity, and cellular protection systems can turn on the oxidative stress response to detect and alleviate adverse conditions. However, the function and mechanism of the protective systems are complicated and remain largely elusive. We report that PTENα, an isoform of the PTEN family, mediates defense signaling in response to oxidative stress during brain aging.

All in One, Self-Powered Bionic Artificial Nerve Based on a Triboelectric Nanogenerator.

Sensory and nerve systems play important role in mediating the interactions with the world. The pursuit of neuromorphic computing has inspired innovations in artificial sensory and nervous systems. Here, an all-in-one, tailorable artificial perception, and transmission nerve (APTN) was developed for mimicking the biological sensory and nervous ability to detect and transmit the location information of mechanical stimulation.

Artificial Intelligence of Things (AIoT) Enabled Virtual Shop Applications Using Self-Powered Sensor Enhanced Soft Robotic Manipulator.

Rapid advancements of artificial intelligence of things (AIoT) technology pave the way for developing a digital-twin-based remote interactive system for advanced robotic-enabled industrial automation and virtual shopping. The embedded multifunctional perception system is urged for better interaction and user experience. To realize such a system, a smart soft robotic manipulator is presented that consists of a triboelectric nanogenerator tactile (T-TENG) and length (L-TENG) sensor, as well as a poly(vinylidene fluoride) (PVDF) pyroelectric temperature sensor.

Low cost exoskeleton manipulator using bidirectional triboelectric sensors enhanced multiple degree of freedom sensory system.

Rapid developments of robotics and virtual reality technology are raising the requirements of more advanced human-machine interfaces for achieving efficient parallel control. Exoskeleton as an assistive wearable device, usually requires a huge cost and complex data processing to track the multi-dimensional human motions. Alternatively, we propose a triboelectric bi-directional sensor as a universal and cost-effective solution to a customized exoskeleton for monitoring all of the movable joints of the human upper limbs with low power consumption.

PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.

The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme complex that regulates many fundamental cellular processes. PP2A is involved in tumorigenesis because mutations in the scaffold subunit, PPP2R1B, were found in several types of cancers. However, the biological function of PPP2R1B remains largely unknown.

Triboelectric nanogenerator sensors for soft robotics aiming at digital twin applications.

Designing efficient sensors for soft robotics aiming at human machine interaction remains a challenge. Here, we report a smart soft-robotic gripper system based on triboelectric nanogenerator sensors to capture the continuous motion and tactile information for soft gripper. With the special distributed electrodes, the tactile sensor can perceive the contact position and area of external stimuli.

Machine Learning Glove Using Self-Powered Conductive Superhydrophobic Triboelectric Textile for Gesture Recognition in VR/AR Applications.

The rapid progress of Internet of things (IoT) technology raises an imperative demand on human machine interfaces (HMIs) which provide a critical linkage between human and machines. Using a glove as an intuitive and low-cost HMI can expediently track the motions of human fingers, resulting in a straightforward communication media of human-machine interactions. When combining several triboelectric textile sensors and proper machine learning technique, it has great potential to realize complex gesture recognition with the minimalist-designed glove for the comprehensive control in both real and virtual space.

Haptic-feedback smart glove as a creative human-machine interface (HMI) for virtual/augmented reality applications.

Human-machine interfaces (HMIs) experience increasing requirements for intuitive and effective manipulation. Current commercialized solutions of glove-based HMI are limited by either detectable motions or the huge cost on fabrication, energy, and computing power. We propose the haptic-feedback smart glove with triboelectric-based finger bending sensors, palm sliding sensor, and piezoelectric mechanical stimulators.

An epidermal sEMG tattoo-like patch as a new human-machine interface for patients with loss of voice.

Throat cancer treatment involves surgical removal of the tumor, leaving patients with facial disfigurement as well as temporary or permanent loss of voice. Surface electromyography (sEMG) generated from the jaw contains lots of voice information. However, it is difficult to record because of not only the weakness of the signals but also the steep skin curvature.

PTENα promotes neutrophil chemotaxis through regulation of cell deformability.

Neutrophils are a major component of immune defense and are recruited through neutrophil chemotaxis in response to invading pathogens. However, the molecular mechanism that controls neutrophil chemotaxis remains unclear. Here, we report that PTENα, the first isoform identified in the PTEN family, regulates neutrophil deformability and promotes chemotaxis of neutrophils.

Self-Powered and Self-Functional Cotton Sock Using Piezoelectric and Triboelectric Hybrid Mechanism for Healthcare and Sports Monitoring.

Wearable devices rely on hybrid mechanisms that possess the advantages of establishing a smarter system for healthcare, sports monitoring, and smart home applications. Socks with sensing capabilities can reveal more direct sensory information on the body for longer duration in daily life. However, the limitation of suitable materials for smart textile makes the development of multifunctional socks a major challenge.

Triboelectric Self-Powered Wearable Flexible Patch as 3D Motion Control Interface for Robotic Manipulator.

Triboelectric nanogenerators and sensors can be applied as human-machine interfaces to the next generation of intelligent and interactive products, where flexible tactile sensors exhibit great advantages for diversified applications such as robotic control. In this paper, we present a self-powered, flexible, triboelectric sensor (SFTS) patch for finger trajectory sensing and further apply the collected information for robotic control. This innovative sensor consists of flexible and environmentally friendly materials, i.

PTENα regulates mitophagy and maintains mitochondrial quality control.

Unlabelled: PTEN plays an important role in tumor suppression, and PTEN family members are involved in multiple biological processes in various subcellular locations. Here we report that PTENα, the first identified PTEN isoform, regulates mitophagy through promotion of PARK2 recruitment to damaged mitochondria. We show that PTENα-deficient mice exhibit accumulation of cardiac mitochondria with structural and functional abnormalities, and PTENα-deficient mouse hearts are more susceptible to injury induced by isoprenaline and ischemia-reperfusion.

PTENα Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning.

PTEN (phosphatase and tensin homology deleted on chromosome 10) has multiple functions, and recent studies have shown that the PTEN family has isoforms. The roles of these PTEN family members in biologic activities warrant specific evaluation. Here, we show that PTENα maintains CaMKII in a state that is competent to induce long-term potentiation (LTP) with resultant regulation of contextual fear memory and spatial learning.

USP9X destabilizes pVHL and promotes cell proliferation.

Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential for tumor growth. Previous studies reported reduction of VHL protein, rather than mRNA in VHL-related tumor patients, suggesting that instability of the pVHL protein itself is a primary cause of dysfunction.

PTEN regulates RPA1 and protects DNA replication forks.

Tumor suppressor PTEN regulates cellular activities and controls genome stability through multiple mechanisms. In this study, we report that PTEN is necessary for the protection of DNA replication forks against replication stress. We show that deletion of PTEN leads to replication fork collapse and chromosomal instability upon fork stalling following nucleotide depletion induced by hydroxyurea.

Elevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.

Purpose: To explore the association between differential Tim-3 and PD-1 expression patterns and HIV disease progression, and to investigate the impact of common γ-chain cytokines on Tim-3 and PD-1 expression patterns on T cells.

Methods: Tim-3/PD-1 expression on the T cells of patients with early and chronic HIV infections was detected. The expression levels and functional profiles of T cells with differential Tim-3 and PD-1 expression patterns induced by γ-chain cytokines were studied.