Achieving Ultra-Narrow-Band Deep-Red Electroluminescence By a Soliton-type Dye Squaraine.

Due to the soliton-like electronic structural characteristics, cyanine dyes typically exhibit spectral behaviors such as large molar extinction coefficients, narrow spectra, and high fluorescence efficiency. However, their extensive applications as emitters in electroluminescence are largely ignored due to their serious emission quenching in the aggregation state. Herein, it is reported a squaraine dye (a type of cyanine) SQPhEt.

MPHGCL-DDI: Meta-Path-Based Heterogeneous Graph Contrastive Learning for Drug-Drug Interaction Prediction.

The combinatorial therapy with multiple drugs may lead to unexpected drug-drug interactions (DDIs) and result in adverse reactions to patients. Predicting DDI events can mitigate the potential risks of combinatorial therapy and enhance drug safety. In recent years, deep models based on heterogeneous graph representation learning have attracted widespread interest in DDI event prediction and have yielded satisfactory results, but there is still room for improvement in prediction performance.

Integrative bioinformatics analysis to screen key genes and signalling pathways related to ferroptosis in obesity.

Ferroptosis is closely associated with the development of disease in the body. However, there are few studies on ferroptosis-related genes (FRGs) in obesity. Therefore, key genes and signalling pathways related to ferroptosis in obesity were screened.

Advanced hormone receptor-positive/human epidermal growth factor receptor 2-positive invasive ductal carcinoma with cecal metastasis: A case report.

The incidence of gastrointestinal metastases from breast cancer (BC) is low. We report a special case of Luminal B (Hormone Receptor positive [HR+]/Human Epidermal Growth Factor receptor 2-positive [HER-2+]) BC. The patient presented with asymptomatic brain metastases two years after radical surgery for modified breast cancer and developed right lower abdominal pain during relief therapy.

Multi-trait analysis reveals large interspecific differences for phytoplankton in response to thermal change.

Understanding the responses of multiple traits in phytoplankton, and identifying interspecific variabilities to thermal changes is crucial for predicting the impacts of ocean warming on phytoplankton distributions and community structures in future scenarios. Here, we applied a trait-based approach by examining the patterns in multi-traits variations (eight traits) and interspecific variabilities in five phytoplankton species (two diatoms, three dinoflagellates) in response to a wide range of ecologically relevant temperatures (14-30 °C). Our results show large inter-traits and interspecific variabilities of thermal reaction norms in all of the tested traits.

Attach importance to the individualized treatment of adult portal hypertension based on etiology and pathogenesis: A review.

There are many factors that can cause portal hypertension and secondary symptoms such as ascites, splenomegaly, and variceal hemorrhage, can seriously affect patients' quality of life and even threaten their lives. In this paper, we summarize various causes of portal hypertension based on etiology and pathogenesis and give individualized treatment strategies in order to remind clinicians to pay attention to the identification of different causes and select corresponding treatment, so that patients are provided with the optimal treatment strategies and benefit from them.

Long-term adaptation to elevated temperature but not CO alleviates the negative effects of ultraviolet-B radiation in a marine diatom.

Multifaceted changes in marine environments as a result of anthropogenic activities are likely to have a compounding impact on the physiology of marine phytoplankton. Most studies on the combined effects of rising pCO, sea surface temperature, and UVB radiation on marine phytoplankton were only conducted in the short-term, which does not allow to test the adaptive capacity of phytoplankton and associated potential trade-offs. Here, we investigated populations of the diatom Phaeodactylum tricornutum that were long-term (∼3.

Investigation of Asian Dyes and Pigments from the Artifact of "Murongzhi" and the Silk Road in China.

In this paper, a series of modern analysis methods, including Raman spectroscopy, X-ray diffraction, UV-vis spectrophotometry, and ultra-high-pressure liquid chromatography coupled with a thermoelectric LTQ-Orbitrap XL ETD mass spectrometer (UHPLC-MS/MS), were applied to analyze and accurately identify the chemical composition of plant dyes and the mineral pigment from the samples collected from grave goods. As a result, the textiles were dyed by the madder, Kermes, , indigo, L., and so forth.

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery.

Introduction: Bleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established.

Directional Migration and Distribution of Magnetic Microparticles in Polypropylene-Matrix Magnetic Composites Molded by an Injection Molding Assisted by External Magnetic Field.

Surface-functionalized polymer composites with spherical particles as fillers offer great qualities and have been widely employed in applications of sensors, pharmaceutical industries, anti-icing, and flexible electromagnetic interference shielding. The directional migration and dispersion theory of magnetic microparticles in polypropylene (PP)-matrix magnetic composites must be studied to better acquire the functional surface with remarkable features. In this work, a novel simulation model based on multi-physical field coupling was suggested to analyze the directed migration and distribution of magnetic ferroferric oxide (FeO) particles in injection molding assisted by an external magnetic field using software.

Fenofibrate Improves Insulin Resistance and Hepatic Steatosis and Regulates the Let-7/SERCA2b Axis in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice.

Fenofibrate is widely used in clinical therapy to effectively ameliorate the development of non-alcoholic fatty liver disease (NAFLD); however, its specific molecular mechanism of action remains largely unknown. MicroRNAs (miRNAs) are key mediators in regulating endoplasmic reticulum (ER) stress during NAFLD, and the deregulation of miRNAs has been demonstrated in NAFLD pathophysiology. The present study aimed to identify whether fenofibrate could influence miRNA expression in NAFLD and investigate the specific mechanism of action of fenofibrate in lipid metabolism disorder-associated diseases.

Combined Approach of Compression Molding and Magnetic Attraction to Micropatterning of Magnetic Polydimethylsiloxane Composite Surfaces with Excellent Anti-Icing/Deicing Performance.

The accumulation of ice and contaminants on the surface of composite insulators will cause high energy consumption or even major hazards to power systems. In this work, the polydimethylsiloxane (PDMS) silicone rubber was modified by surface micropatterning and material compositing. Highly crosslinked poly(cyclotriphosphazene--4,4'-sulfonyldiphenol) (PZS) was used to directly coat ferroferric oxide (FeO) nanoparticles.

Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line.

Background: Vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori (H. pylori). It was previously believed that VacA can trigger the cascade of apoptosis on mitochondria to lead to cell apoptosis.

Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy.

Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, and hyperlipidemia. Metformin is commonly used to treat type 2 diabetes mellitus and, in recent years, it was found to play a potential role in the amelioration of NAFLD. However, the mechanisms underlying the protective effect of metformin against NAFLD remain largely unknown.

Long-Lived T-Shaped Micropillars with Submicron-Villi on PP/POE Surfaces with Grinding-Enhanced Water Repellency Fabricated via Hot Compression Molding.

Superhydrophobic properties are derived from the roughness of the surface of micro/nanostructures and low-surface-energy materials. However, they are both easy to damage on superhydrophobic surfaces after mechanical abrasion in practical applications, resulting in the transition from the Cassie-Baxter state to the Wenzel state and even the loss of water repellency. In this work, the mechanical properties of polypropylene (PP) toughened with poly(ethylene--octene) (POE) were improved for the fabrication of long-lived T-shaped micropillars with submicron-villi on top by a combined method of compression molding and grinding.

Constructing a Green Light Photodetector on Inorganic/Organic Semiconductor Homogeneous Hybrid Nanowire Arrays with Remarkably Enhanced Photoelectric Response.

We demonstrate that a novel photodetector is constructed by CdS/poly( p-phenylene vinylene) (PPV) homogeneous hybrid nanowire arrays via a simple template-assisted electrochemical codeposition approach. Owing to the well-matched energy levels between CdS and PPV, the recombination of photogenerated electrons and holes in CdS/PPV hybrid nanowire arrays is greatly inhibited. It is found that the homogeneous hybrid nanowire arrays exhibit remarkably enhanced photoelectric response and the ON/OFF ratio by 17 times compared to the individual CdS component.

Total endoscopic repair of atrial septal defect under on-pump beating heart.

Background: We previously reported the techniques for total endoscopic atrial septal defect (ASD) repair on hearts arrested with cardioplegia through three small incisions in the chest wall without aid of a surgical robotic system. The optimal results motivated us to use total thoracoscopic technology for ASD on perfused beating hearts.

Methods: From 2010 to 2017, 161 patients with a mean age of 28.