CeONPs relieve radiofrequency radiation, improve testosterone synthesis, and clock gene expression in Leydig cells by enhancing antioxidation.

The ratio of Ce/Ce in their structure confers unique functions on cerium oxide nanoparticles (CeONPs) containing rare earth elements in scavenging free radicals and protecting against oxidative damage. The potential of CeONPs to protect testosterone synthesis in primary mouse Leydig cells during exposure to 1,800 MHz radiofrequency (RF) radiation was examined in vitro. Leydig cells were treated with different concentrations of CeONPs to identify the optimum concentration for cell proliferation.

[Effects of cerium oxide nanoparticles on cognitive function in 48 h sleep deprived male mice].

Objective: To study the effects of cerium oxide nanoparticles( CeO_2 NPs)on cognitive function in 48 hours of sleep deprived male mice and explore its mechanism.

Methods: Thirty-six healthy clean ICR male mice( four weeks old) were randomly divided into 6 groups: blank control group, solvent control group, sleep deprivation control group, low, medium and high dose groups of CeO_2 NPs. 1 m L of distilled water were given to mice of blank group, 1 m L of solvent were given to mice of solvent control and sleep deprivation control group, 1 mL of CeO_2 NPs solvent( 4, 8, 16 mg/kg) were administered to mice of low, medium and high dose groups of CeO_2 NPs.