Publications by authors named "Mingkai Yang"
Considering the indispensable significance and utilities of meta-substituted pyridines in medicinal, chemical as well as materials science, a direct meta-selective C-H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. In general, established methods for meta C-H functionalization of pyridines rely on the utilization of tailored electrophilic reagents to realize the intrinsic polarity match. Herein, we report a complementary electrochemical methodology; diverse nucleophilic sulfinates allow meta-sulfonylation of pyridines through a redox-neutral dearomatization-rearomatization strategy by a tandem dearomative cycloaddition/hydrogen-evolution electrooxidative C-H sulfonation of the resulting oxazino-pyridines/acid-promoted rearomatization sequence.
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- Hair follicles go through cycles of growth, rest, and regression supported by stem cells, and certain mutations can disrupt these processes, leading to hair loss and skin inflammation.
- An overexpression of the Gsdma3 gene in mice causes significant disruptions in hair cycling, including cell death during key stages that leads to hair follicle degeneration.
- The study reveals that while immune cells are present in the affected areas, they do not seem to directly cause hair follicle damage, suggesting that Gsdma3 plays a critical role in maintaining the hair follicle stem cell environment.