Publications by authors named "Mingjun Ao"
Protein phosphorylation is a pivotal post-translational modification modulating various cellular processes. In Gram-positive bacteria, the protein arginine kinase McsB, along with its activator McsA, has a key role in labeling misfolded and damaged proteins during stress. However, the activation mechanism of McsB by McsA remains elusive.
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- Despite progress in HIV treatment through antiretroviral therapy (ART), limitations like lifelong medication and viral resistance drive the need for new approaches.
- Ibalizumab is currently the only approved CD4-specific antibody, and research into anti-CD4 nanobodies, particularly one called Nb457 from an alpaca, shows promise for better efficacy against HIV-1.
- Nb457, especially in its engineered trimeric form, not only surpasses Ibalizumab in effectiveness but also demonstrates significant therapeutic benefits in mouse models, indicating potential for future clinical applications.
Electrochemical Monitoring of Real-Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette.
Angew Chem Int Ed Engl
September 2024
The microtubule-associated protein tau participates in neurotransmission regulation via its interaction with synaptic vesicles (SVs). The precise nature and mechanics of tau's engagement with SVs, especially regarding alterations in vesicle dynamics, remain a matter of discussion. We report an electrochemical method using a synapse-mimicking nanopipette to monitor vesicle dynamics induced by tau.
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