NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging.

Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) and inflammatory factors levels in the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays a vital role in this fatal lung injury. At present, we developed a novel class of polydopamine (PDA) coated cerium dioxide (CeO) nanozyme (Ce@P) that acts as the potent ROS scavenger for scavenging intracellular ROS and suppressing inflammatory responses against ALI.

Bioinformatics analyses of immune-related genes and immune infiltration associated with lung ischemia-reperfusion injury.

Background: Ischemia-reperfusion injury (IRI) is a significant complication that can occur following lung transplantation and is known to contribute to poor prognosis. Our research aimed to investigate the potential molecular targets and mechanisms involved in lung IRI (LIRI), in order to improve our understanding of this condition.

Method: We downloaded gene expression datasets (GSE127003 and GSE18995) linked to LIRI from the GEO database.

Genipin modified lyophilized platelet-rich fibrin scaffold for sustained release of growth factors to promote bone regeneration.

Lyophilized platelet-rich fibrin (L-PRF) was shown to further activate resident platelets in platelet-rich fibrin causing a higher amount of growth factors release. However, it still required further experimental studies to resolve the uncontrolled degradation and burst release problem. In this study, the nature crosslinker genipin is introduced to improve the performance of L-PRF scaffold.

The effect and mechanism of gene Fam20a on the development and function of salivary glands in mice.

Objective: The influence of the knockout of gene Fam20a on mice salivary glands was studied in this research, to provide a potential gene therapeutic target for salivary gland dysfunction.

Design: The control group with genotype Fam20a and conditional knockout (cKO) group with Fam20a;K14-Cre were constructed with Cre-Loxp. The influence of Fam20a on the salivary glands was studied in terms of morphology, functionality and molecular mechanism.

Analysis of Hub Genes Involved in Distinction Between Aged and Fetal Bone Marrow Mesenchymal Stem Cells by Robust Rank Aggregation and Multiple Functional Annotation Methods.

Stem cells from fetal tissue protect against aging and possess greater proliferative capacity than their adult counterparts. These cells can more readily expand and senesce later in culture. However, the underlying molecular mechanisms for these differences are still not fully understood.

Distributed measurement of dynamic strain based on multi-slope assisted fast BOTDA.

We propose and demonstrate a dynamic Brillouin optical fiber sensing based on the multi-slope assisted fast Brillouin optical time-domain analysis (F-BOTDA), which enables the measurement of a large strain with real-time data processing. The multi-slope assisted F-BOTDA is realized based on the double-slope demodulation and frequency-agile modulation, which significantly increases the measurement range compared with the single- or double- slope assisted F-BOTDA, while maintaining the advantage of fast data processing and being suitable for real-time on-line monitoring. A maximum strain variation up to 5000με is measured in a 32-m fiber with a spatial resolution of ~1m and a sampling rate of 1kHz.

Hyperexcitability to electrical stimulation and accelerated muscle fatiguability of taut bands in rats.

Objective: Myofascial trigger points contribute significantly to musculoskeletal pain and motor dysfunction and may be associated with accelerated muscle fatiguability. The aim of this study was to investigate the electrically induced force and fatigue characteristics of muscle taut bands in rats.

Methods: Muscle taut bands were dissected out and subjected to trains of electrical stimulation.