Meynert nucleus-related cortical thinning in Parkinson's disease with mild cognitive impairment.

Background: Cognitive impairment in Parkinson's disease (PD) involves the cholinergic system and cholinergic neurons, especially the nucleus basalis of Meynert (NBM/Ch4) located in the basal forebrain (BF). We analyzed associations between NBM/Ch4 volume and cortical thickness to determine whether the NBM/Ch4-innervated neocortex shows parallel atrophy with the NBM/Ch4 as disease progresses in PD patients with cognitive impairment (PD-MCI).

Methods: We enrolled 35 PD-MCI patients, 48 PD patients with normal cognition (PD-NC), and 33 age- and education-matched healthy controls (HCs), with all participants undergoing neuropsychological assessment and structural magnetic resonance imaging (MRI).

Morphological parameters of middle cerebral arteries associated with aneurysm formation.

Purpose: The objective of this work was to investigate the correlation between morphological parameters of the MCA and the formation of aneurysms.

Methods: MCA aneurysms were diagnosed in 122 cases using CT angiography (including 30 cases of M1 proximal aneurysms, 70 cases of M1 bifurcation aneurysms, and 22 cases of distal aneurysms). Images from these cases were retrospectively compared with images from 50 healthy controls.

Changes of brain structural network connection in Parkinson's disease patients with mild cognitive dysfunction: a study based on diffusion tensor imaging.

Introduction: Previous studies have found that white matter (WM) alterations might be correlated in Parkinson's disease (PD) patients with cognitive impairment. This study aimed to investigate WM structural network connectome alterations in PD patients with mild cognitive impairment (PD-MCI) and assess the relationship between cognitive impairment and structural topological network changes in PD patients.

Methods: All 31 healthy controls (HCs) and 71 PD patients (43 PD-NC and 28 PD-MCI) matched for age, sex and education underwent 3.

The clinical characteristics and cognitive features of mild cognitive impairment in Parkinson's disease and the analysis of relevant factors.

The purpose of this work is to investigate the clinical characteristics, cognitive impairment features, and subgroup types of Parkinson's disease (PD) subjects with mild cognitive impairment (PD-MCI) in the Chinese population and to analyze relevant risk factors for PD-MCI. A total of 234 non-dementia PD subjects were collected. Standardized neuropsychological assessments of overall cognitive level and four cognitive domains (memory, executive function, attention and visuospatial function) were performed using MDS Task Force diagnostic criteria for PD-MCI.

Changes in Cortical Thickness in Patients With Early Parkinson's Disease at Different Hoehn and Yahr Stages.

This study was designed to explore changes in cortical thickness in patients with early Parkinson's disease (PD) at different Hoehn and Yahr (H-Y) stages and to demonstrate the association of abnormally altered brain regions with part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III). Sixty early PD patients and 29 age- and gender-matched healthy controls (HCs) were enrolled in this study. All PD patients underwent comprehensive clinical and neuropsychological evaluations and 3.

Changes of brain structure in Parkinson's disease patients with mild cognitive impairment analyzed via VBM technology.

Objective: To analyze changes in cerebral grey matter volume and white matter density in non-dementia Parkinson's disease patients using voxel-based morphometry (VBM) technology; to investigate features of brain structure changes in Parkinson's disease patients with mild cognitive impairment (PD-MCI), and reveal their intrinsic pathological changes.

Methods: Based on the diagnostic criteria of PD-MCI, 23 PD-MCI patients, 23 Parkinson's disease patients with normal cognition (PD-NC), and 21 age- and gender-matched healthy people were recruited for the study. Scans were performed on all subjects on a 3.