Shuanglongjiegu pill promoted bone marrow mesenchymal stem cell osteogenic differentiation by regulating the miR-217/RUNX2 axis to activate Wnt/β-catenin pathway.

This study aimed to investigate the effects of Shuanglongjiegu pill (SLJGP) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and explore its mechanism based on miR-217/RUNX2 axis. Results found that drug-containing serum of SLJGP promoted BMSCs viability with a dose-dependent effect. Under osteogenic differentiation conditions, SLJGP promoted the expression of ALP, OPN, BMP2, RUNX2, and the osteogenic differentiation ability of BMSCs.

Antioxidant and anti‑inflammatory effects of esculin and esculetin (Review).

is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of and its glycoside form is called esculin.

miR-155-5p improves oocyte maturation in porcine cumulus cells through connexin 43-mediated regulation of MPF activity.

In this study, we aimed to investigate the effect of the expression of miR-155-5p and its target genes on oocyte maturation. We analyzed the expression of miR-155-5p and its target genes in cumulus cells and oocytes using quantitative real-time reverse-transcription polymerase chain reaction. Using carboxyfluorescein, porcine cumulus cells were transfected with mimics and inhibitors of ssc-miR-155-5p to induce in vitro maturation, and subsequently, cumulus expansion, oocyte maturation, and cleavage rate were measured.

Bending modulus of the rippled graphene: the role of thickness.

Bending modulus is a key parameter to characterize the stiffness of materials. Commonly, it is believed that the bending modulus is closely related to the thickness as described by the thin plate theory. However, the thin plate theory fails in multilayer van der Waals materials like multilayer graphene, suggesting a more complex relationship between the bending modulus and thickness.

Dynamic analysis of a SIQR epidemic model considering the interaction of environmental differences.

Infectious diseases have a devastating impact on individual health and social development. Different external environmental factors will affect the scale and the speed of disease outbreaks, such as sanitary conditions and policy interventions. In this paper, we attempt to establish a dual-system susceptible-infectious-quarantine-recovered model with different environmental impacts to explore it.

Nickel-vanadium layered double hydroxide nanosheets as the saturable absorber for a passively Q-switched 2 µm solid-state laser.

Nickel-vanadium (NiV)-layered double hydroxide (LDH) was fabricated into a novel saturable absorber (SA) by the liquid phase exfoliation method and utilized as the laser modulator for the first time, to our best knowledge. We investigated a passive -switched Tm:YAG ceramic laser at 2 µm with the NiV-LDH SA. Under an absorbed pump power of 7.

Role of ferroptosis in neurological diseases.

Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides which leads to oxidative stress and cell death. Recent studies have indicated that ferroptosis plays an essential role in the pathology of neurological diseases, such as intracerebral hemorrhage, ischemic stroke, epilepsy, neurodegenerative diseases, traumatic brain injury and brain cancer. This review focuses on the latest researches on the relationship of ferroptosis with nervous system diseases, highlighting the ferroptosis-based mechanisms, and elaborating the new perspective therapeutic targets of neurological disorders.

Scutellarin regulates osteoarthritis by inhibiting the PI3K/AKT/mTOR signaling pathway.

Osteoarthritis (OA) is a highly prevalent disease worldwide that causes disability and diminishes the quality of life of affected individuals. The disease is characterized by cartilage destruction, increased inflammatory responses and cholesterol metabolic disorder. Scutellarin is the major active ingredient extracted from , and it has been demonstrated to possess various pharmacological functions in the treatment of the disease.

High efficiency, linearly polarized, directly diode-pumped Er:YAG laser at 1617 nm.

An efficient, directly diode-pumped Er:YAG laser at 1617 nm was demonstrated. A folding mirror with high reflectivity for the s-polarized light at the laser wavelength was used to achieve a linearly polarized laser. A maximum continuous-wave output power of 7.

In-band pumped polarized, narrow-linewidth Er:YAG laser at 1645 nm.

We report a polarized, narrow-linewidth Er:YAG laser operating at 1645 nm, in-band pumped by a continuous-wave (CW), narrowband 1532 nm fiber-coupled laser diode (LD). A maximum polarized continuous wave output power of 8.45 W was obtained, resulting in an optical conversion efficiency of 56% with respect to the absorbed pump power.

[Association between left ventricular diastolic function and blood pressure variability in essential hypertensive patients].

Objective: To investigate the relationship between blood pressure variability (BPV) and left ventricular diastolic function in patients with essential hypertension.

Methods: Left ventricular diastolic function of 252 hypertensive patients were assessed by early (E) diastolic transmitral flows to early diastolic mitral annular velocity (Ea) (E/Ea) ratio derived from Doppler echocardiography. Patients were divided into two groups according to normal left ventricular diastolic function group (E/Ea<15, n = 168) and left ventricular diastolic dysfunction group (E/Ea ≥ 15, n = 84).

High-energy directly diode-pumped Q-switched 1617 nm Er:YAG laser at room temperature.

We describe high-energy Erbium-doped yttrium aluminum garnet (Er:YAG) lasers operating at 1617 nm, resonantly pumped using 1532 nm fiber-coupled laser diodes. A maximum continuous wave output power of 4.3 W at 1617 nm was achieved with an output coupler of 20% transmission under incident pump power of 29.

Efficient all-solid-state mid-infrared optical parametric oscillator based on resonantly pumped 1.645 μm Er:YAG laser.

We first report an all-solid-state tunable mid-infrared singly resonant optical parametric oscillator based on a 1532 nm laser diode resonantly pumped, Q-switched 1.645 μm Er:YAG laser. An MgO-doped periodically poled lithium niobate was used as the nonlinear material.

Efficient 1645 nm continuous-wave and Q-switched Er:YAG laser pumped by 1532 nm narrow-band laser diode.

Energy transfer upconversion induced thermal effects are mainly responsible for the low efficiency of laser diode pumped Er:YAG lasers. The current work adopts Er:YAG rods with 0.25% Er(3+) doping concentration, instead of the commonly used rods with 0.

Equivalent optical model for lenslike gain medium in continuously single-end-pumped solid-state laser.

In order to conveniently and precisely estimate the spot size of laser modes in continuously single-end-pumped solid-state lasers, a ray matrix for the thermal-induced lenslike medium with exponential heat distribution along the axial direction is, for the first time to our best knowledge, derived under assumptions of only radial heat flow and uniform pump spot size. An equivalent optical model is also developed and especially modified for a lenslike gain medium in a continuously single-end-pumped solid-state laser. The result is verified by discussing how it fits the practical cases much better than the previous simplified model and by numerical simulation in a practice problem.

Continuous wave and passively Q-switched Nd:Lu xY1-x VO4 laser at 1.34 μm with V3+:YAG as the saturable absorber.

We demonstrated a diode-pumped continuous wave and passively Q-switched Nd:Lu(x)Y(1-x)VO4 laser at 1.34 μm with V3+:YAG as the saturable absorber. The crystal Nd:Lu(x)Y(1-x)VO4 with equal ionic ratio (x = 0.

Efficient Q-switched Tm:YAG ceramic slab laser.

Characteristics of Tm:YAG ceramic for high efficient 2-μm lasers are analyzed. Efficient diode end-pumped continuous-wave and Q-switched Tm:YAG ceramic lasers are demonstrated. At the absorbed pump power of 53.

Some polycyclic aromatic hydrocarbons in vegetables from northern China.

Nine important vegetables were collected from northern Chinese wholesale markets and analyzed for polycyclic aromatic hydrocarbon (PAH) contents. Anthracene, flupranthene, benzo(a)anthracene and benzo(a)pyrene were determined. The contents of the four PAH congeners were at the same level with the mean concentrations 6.