[Ligustrazine alleviates the tissue injury of the submandibular glands by enhanceing the antioxidant and anti-inflammatory effects in diabetic rats].

Objective To study the effects of ligustrazine on the expression of heme oxygenase 1 (HO-1)/carbon monoxide (CO), inducible nitric oxide synthase (iNOS)/nitric oxide (NO) and tumor necrosis factor α (TNF-α) in the submandibular glands (SMGs) of diabetic rats and their implications. Methods Thirty SD rats were randomly divided into control group, diabetic mellitus (DM) group and ligustrazine group, with 10 rats in each group. The control group received no treatment.

Insulin on changes in expressions of aquaporin-1, aquaporin-5, and aquaporin-8 in submandibular salivary glands of rats with Streptozotocin-induced diabetes.

Objective: This study aimed to explore the relationship between diabetic xerostomia and changes in aquaporin-1 (AQP1), aquaporin-5 (AQP5), and aquaporin-8 (AQP8) expression in the submandibular glands (SMGs), to further study the pathogenesis of diabetic xerostomia and to observe the therapeutic effect of insulin (INS).

Methods: Thirty SD rats were randomized equally into 3 groups: control group, diabetic model (DM) group and insulin (INS) group (n=10, respectively). The control group received no treatment.