Publications by authors named "Minghui Gao"

Alteration or abnormal activation of RTKs have been recurrently observed and recognized as an important driving factor in the progression of many human cancers. Ferroptosis, an iron-dependent form of regulated necrosis triggered by the accumulation of lethal lipid peroxides on cell membranes, has been implicated in various tumor types. Here we reported that oncogenic RTKs/RAS/RAF/c-Myc axis promotes cancer cells to ferroptosis.

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  • Relative permeability curves play a vital role in understanding how multiphase flow operates in petroleum reservoirs, impacting heavy oil recovery during emulsion flooding.
  • This study develops a model that incorporates emulsification and emulsion transport to accurately characterize relative permeability, using parameters like emulsion concentration and capillary number.
  • The results indicate that the inversion method used to estimate relative permeability curves aligns closely with experimental data, showing less than a 10% error margin, thus confirming the model's effectiveness for predicting flow behavior in heavy oil reservoirs.
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Extrahepatic cholangiocarcinoma (ECC), a highly malignant type of cancer with increasing incidence, has a poor prognosis due to limited treatment options. Based on genomic analysis of ECC patient samples, here we report that aldo-keto reductase family 1 member C1 (AKR1C1) is highly expressed in human ECC tissues and closely associated with ECC progression and poor prognosis. Intriguingly, we show that inducible AKR1C1 knockdown triggers ECC cells to undergo ferroptosis.

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Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19--rhynchophylloside A (), 7--rhynchophylloside A (), and 7--anthocephalusine A (), were isolated from the hook-bearing branches of . The structures and absolute configurations of were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids and showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.

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  • - Twelve compounds were identified from the leaves and twigs of a specific plant, including four new compounds: 6,7α-limondiol, ethyl 19-hydroxyisoobacunoate diosphenol, -benzoyl 3-prenyltyramine, and 9--methyl integrifoliodiol.
  • - The structures of these compounds were determined using mass spectrometry (MS), nuclear magnetic resonance (NMR), and single-crystal X-ray diffraction techniques.
  • - The compounds showed immunosuppressive effects, inhibiting the growth of T lymphocytes and B cells stimulated by ConA and LPS, respectively.
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The negative regulation on neurogenesis has been implicated in fluoride neurotoxicity, while the evidence is limited. To explore whether fluoride interferes with neurogenesis via the Notch1 signaling and the potential alleviation effects of carvacrol (CAR), we conducted in vivo and in vitro experiments, as well as epidemiological analyses in this study. The results showed that urinary fluoride levels and circulating Notch1 levels were associated with IQ levels in boys.

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Capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-CD) has proven to be an efficient technique for the separation and detection of charged inorganic, organic, and biochemical analytes. It offers several advantages, including cost-effectiveness, nanoliter injection volume, short analysis time, good separation efficiency, suitability for miniaturization, and portability. However, the routine determination of common inorganic cations (NH, K, Na, Ca, Mg, and Li) and inorganic anions (F, Cl, Br, NO, NO, PO, and SO) in water quality monitoring typically exhibits limits of detection of about 0.

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Correction for 'A compact and high-performance setup of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-CD)' by Lin Li , , 2024, https://doi.org/10.1039/d4an00354c.

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Capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-CD) has the advantages of high throughput (simultaneous detection of multiple ions), high separation efficiency (higher than 10 theoretical plates) and rapid analysis capability (less than 5 min for common inorganic ions). A compact CE-CD system is ideal for water quality control and on-site analysis. It is suitable not only for common cations ( Na, K, Li, NH, Ca, .

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Ferroptosis is an iron-dependent and lipid peroxides (LPO)-overloaded programmed damage cell death, induced by glutathione (GSH) depletion and glutathione peroxide 4 (GPX4) inactivation. However, the inadequacy of endogenous iron and reactive oxygen species (ROS) restricts the efficacy of ferroptosis. To overcome this obstacle, a near-infrared photo-responsive FeP@PEG NPs is fabricated.

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Article Synopsis
  • - Macroautophagy is a complex process that can lead to cell death, influenced by various cell types and stressors, while ferroptosis is a specific kind of cell death related to lipid damage and iron dependency.
  • - Certain types of autophagy, like ferritinophagy and lipophagy, play a role in triggering ferroptotic cell death by degrading protective proteins, whereas others, such as reticulophagy, help protect cells from this damage.
  • - The review seeks to clarify the relationship between autophagy and ferroptosis, focusing on defining terms, outlining key components, discussing experimental techniques, and providing interpretation guidelines for ongoing research.
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Genetically engineered macrophages (GEMs) have emerged as an appealing strategy to treat cancers, but they are largely impeded by the cell availability and technical challenges in gene transfer. Here, we develop an efficient approach to generate large-scale macrophages from human induced pluripotent stem cells (hiPSCs). Starting with 1 T150 dish of 10 hiPSCs, more than 10 mature macrophages (iMacs) could be generated within 1 month.

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Emergency myelopoiesis (EM) is essential in immune defense against pathogens for rapid replenishing of mature myeloid cells. During the EM process, a rapid cell-cycle switch from the quiescent hematopoietic stem cells (HSCs) to highly proliferative myeloid progenitors (MPs) is critical. How the rapid proliferation of MPs during EM is regulated remains poorly understood.

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Background: Rice taste is closely associated with endosperm composition, which varies among different rice layers. Although clarifying the relationship between this difference and nutritional taste can guide rice breeding and cultivation practices, research on this topic is limited.

Results: Here, typical rice varieties having excellent and poor taste characteristics were selected to analyze the distribution characteristics and differences of their components.

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The underlying mechanism of fluorosis has not been fully elucidated. The purpose of this study was to explore the mechanism of fluorosis induced by sodium fluoride (NaF) using proteomics. Six offspring rats exposed to fluoride without dental fluorosis were defined as group A, 8 offspring rats without fluoride exposure were defined as control group B, and 6 offspring rats exposed to fluoride with dental fluorosis were defined as group C.

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(TV) may have an impact on other reproductive tract infections. Studies on the connection between the infection of TV and human papillomavirus (HPV) have been inconsistent. We performed a systematic review of the relevant articles through keywords that satisfy the criteria and filtered the articles according to the inclusion and exclusion criteria.

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  • The study explored the prevalence of a specific pathogen causing trichomoniasis among men in Xinxiang, collecting 634 clinical samples from semen, prostate fluid, and urine over a 14-month period.
  • Out of these samples, 32 tested positive for the pathogen, leading to detection rates of 7.87% in semen, 4.65% in prostate fluid, and 2.97% in urine.
  • Genetic analysis identified the strains as genotype E, showing high homology with a previously published strain, highlighting the importance of these genetic markers in understanding trichomoniasis in men, though further research is needed on genotype-pathogenicity links.
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Itch is an uncomfortable and complex sensation that elicits the desire to scratch. The nucleus accumbens (NAc) activity is important in driving sensation, motivation, and emotion. Excitatory afferents from the medial prefrontal cortex (mPFC), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor D1-expressing and D2-expressing medium spiny neurons (Drd1-MSN and Drd2-MSN) in the NAc.

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Cryptosporidium parvum has gained much attention as a major cause of diarrhea in the world, particularly in those with compromised immune systems. The data currently available on how the immune system recognizes C. parvum are growing rapidly, but we lack data on the interactions among host major histocompatibility complex (MHC) diversity and parasitic T-cell epitopes.

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The (Boulenger, 1900) is a small Cyprinidae fish that has a wide distribution in China. In this study, we characterized the complete mitochondrial genome of by the Illumina NovaSeq sequencing platform in Guangxi, China. The assembled mitogenome is 16,647 base pairs (bp) and consists of 13 protein-coding genes (PCGs), 22 transfer RNAs, two ribosomal RNAs, and a control region (D-loop).

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The deposition of wax on the surface of the pipeline or the facilities is harmful to oil industries, which can cause serious safety problems and economic loss. To address this problem, a degradable glutinous rice/chitosan-phytic acid composite coating (GR/CS-PA) was prepared. The GR can serve as an adhesive, and it can also enhance the flexibility of CS-PA.

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Given the high incidence and high mortality of cervical cancer (CC) among women in developing countries, identifying reliable biomarkers for the prediction of prognosis and therapeutic response is crucial. We constructed a prognostic signature of cuproptosis-related long non-coding RNAs (lncRNAs) as a reference for individualized clinical treatment. A total of seven cuproptosis-related lncRNAs closely related to the prognosis of patients with CC were identified and used to construct a prognostic signature via least absolute shrinkage and selection operator regression analysis in the training set.

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  • Fluoride intake can lead to dental fluorosis, and this study analyzed the effects of sodium fluoride on offspring rats by comparing a fluorosis group to a control group.
  • Advanced techniques like liquid chromatography and mass spectrometry identified a total of 169 differently expressed proteins and metabolites in the rats' blood, highlighting significant biological changes.
  • Two key pathways associated with dental fluorosis were identified: the HIF-1 pathway and glycolysis/gluconeogenesis, indicating that these pathways play a significant role in the condition.
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Herein, we describe the copper-catalyzed arylalkylation of activated alkenes via hydrogen-atom transfer and aryl migration strategy. The reaction was carried out through a radical-mediated continuous migration pathway using -fluorosulfonamides as the alkyl source. The primary, secondary, and tertiary alkyl radicals formed by intramolecular hydrogen-atom transfer proceeded smoothly.

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A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine--oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group compatibility and broad substrate scope.

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