A nanofiltration and electrocatalytic membrane reactor with ozone oxidation integrated system for dyeing wastewater treatment and NaSO recovery.

Removal of organic pollutants while recovering NaSO is crucial for the dyeing wastewater resourcefulness. In this study, nanofiltration (NF) was used for the treatment of industrial dyeing wastewater (COD=294.2 mg L, the concentration of NaSO = 3.

Nitazoxanide inhibits pili assembly by targeting BamB to synergize with polymyxin B against drug-resistant Escherichia coli.

Gram-negative bacteria rely on pili assembly for pathogenicity, with the chaperone-usher (CU) pathway regulating pilus biogenesis. Nitazoxanide (NTZ) inhibits CU pathway-mediated P pilus biogenesis by specifically interfering with the proper folding of the outer membrane protein (OMP) usher, primarily mediated by the β-barrel assembly machinery (BAM) complex. In this study, we identified the BAM complex components BamB and the BamA POTRA2 domain as key binding targets for NTZ.

CSEL-BGC: A Bioinformatics Framework Integrating Machine Learning for Defining the Biosynthetic Evolutionary Landscape of Uncharacterized Antibacterial Natural Products.

The sluggish pace of new antibacterial drug development reflects a vulnerability in the face of the current severe threat posed by bacterial resistance. Microbial natural products (NPs), as a reservoir of immense chemical potential, have emerged as the most promising avenue for the discovery of next generation antibacterial agent. Directly accessing the antibacterial activity of potential products derived from biosynthetic gene clusters (BGCs) would significantly expedite the process.

Mortality in patients admitted to hospital with heart failure in China: a nationwide Cardiovascular Association Database-Heart Failure Centre Registry cohort study.

Background: China has the largest burden of heart failure worldwide. However, large-scale studies on heart failure mortality are scarce. We aimed to investigate mortality and identify risk factors for mortality among patients with heart failure in China.

Replacing Spartina alterniflora with northward-afforested mangroves has the potential to acquire extra blue carbon.

Climate change provides an opportunity for the northward expansion of mangroves, and thus, the afforestation of mangroves at higher latitude areas presents an achievable way for coastal restoration, especially where invasive species S. alterniflora needs to be clipped. However, it is unclear whether replacing S.

In situ surface turbidity sensor based on localized light scattering from tilted fiber Bragg gratings.

We propose a compact fiber-optic sensor for in situ and continuous turbidity monitoring, based on surface optical scattering of polarized evanescent waves from targeted particles. The sensor is composed of a tilted fiber Bragg grating (TFBG) packaged inside a microfluidic capillary. The transmission spectrum of the TFBG provides a fine comb of narrow cladding resonances that are highly sensitive to the turbidity due to the localized light scattering of polarized evanescent waves from the microparticles near the fiber surface (as opposed to traditional bulk/volumetric turbidity measurement).

Functioning and mechanisms of PTMs in renal diseases.

Post-translational modifications (PTMs) are crucial epigenetic mechanisms that regulate various cellular biological processes. The use of mass spectrometry (MS)-proteomics has led to the discovery of numerous novel types of protein PTMs, such as acetylation, crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, protein propionylation and butyrylation, succinylation, malonylation, lactylation, and histone methylation. In this review, we specifically highlight the molecular mechanisms and roles of various histone and some non-histone PTMs in renal diseases, including diabetic kidney disease.

Implication of different frailty criteria in older people with atrial fibrillation: a prospective cohort study.

Background: the prevalence of physical and multidimensional frailty and their prognostic impact on clinical outcomes in patients with atrial fibrillation (AF) is unclear.

Objective: to evaluated frailty in a cohort of patients with AF according to different criteria, and studied the prevalence and its prognostic impact on clinical outcomes.

Methods: in this multicenter prospective cohort, 197 inpatients ≥ 65 years old with AF were recruited from September 2018 to April 2019.

Clinical significance of the series of variants, an unignorable predictor of warfarin sensitivity in Chinese population.

Backgrounds: Gene polymorphisms are critical for variations in warfarin dose. To date, more than 70 alleles have been identified. This study was designed to clarify the clinical significance of variants to warfarin sensitivity in Chinese Han patients.

Identification and Validation of a Novel Glycolysis-Related Gene Signature for Predicting the Prognosis and Therapeutic Response in Triple-Negative Breast Cancer.

Introduction: A high malignancy rate and poor prognosis are common problems with triple-negative breast cancer (TNBC). There is increasing evidence that glycolysis plays vital roles in tumorigenesis, tumor invasion, immune evasion, chemoresistance, and metastasis. However, a comprehensive analysis of the diagnostic and prognostic significance of glycolysis in TNBC is lacking.

H S improves salt-stress recovery via organic acid turn-over in apple seedlings.

Signalling roles of hydrogen sulphide (H S) in stress biology are widely reported but not sufficiently established to urge its use in agronomic practice. Our lack of quantitative understanding of the metabolic rewiring in H S signalling makes it difficult to elucidate its functions in stress tolerance on the biochemical level. Here, Malus hupehensis Rehd.

Application of Massive Open Online Course to Grammar Teaching for English Majors Based on Deep Learning.

The study aims to explore the roles of Massive Open Online Courses (MOOCs) based on deep learning in college students' English grammar teaching. The data are collected using a survey. After the experimental data are analyzed, it is found that students have a low sense of happiness and satisfaction and are unwilling to practice oral English and learn language points in English learning.

Development and Validation of an Electronic Frailty Index Using Routine Electronic Health Records: An Observational Study From a General Hospital in China.

This study aimed to develop and validate an electronic frailty index (eFI) based on routine electronic health records (EHR) for older adult inpatients and to analyze the correlations between frailty and hospitalized events and costs. We created an eFI from routine EHR and validated the effectiveness by the consistency of the comprehensive geriatric assessment-frailty index (CGA-FI) with an independent prospective cohort. Then, we analyzed the correlations between frailty and hospitalized events and costs by regressions.

Particulate plastics-plant interaction in soil and its implications: A review.

Particulate plastics (<5 mm), including macroplastics (1 μm to 5 mm), microplastics (100 nm to 1 μm) and nanoplastics (<100 nm), have become a global environmental problem due to their widespread occurrence, distribution and ecosystem risk. Although numerous studies on particulate plastics have been conducted in aquatic systems, investigations in the soil ecosystem are lacking. Soil is the main storage place of particulate plastics, conferring significant impacts on plant growth and development.

Prevalence and Incidence of Heart Failure Among Urban Patients in China: A National Population-Based Analysis.

Background: Large-scale and population-based studies of heart failure (HF) incidence and prevalence are scarce in China. The study sought to estimate the prevalence, incidence, and cost of HF in China.

Methods: We conducted a population-based study using records of 50.

Flexible Fiber Probe for Efficient Neural Stimulation and Detection.

Functional probes are a leading contender for the recognition and manipulation of nervous behavior and are characterized by substantial scientific and technological potential. Despite the recent development of functional neural probes, a flexible biocompatible probe unit that allows for long-term simultaneous stimulation and signaling is still an important task. Here, a category of flexible tiny multimaterial fiber probes (<0.

Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats.

Context: Rivaroxaban and ticagrelor are two common drugs for the treatment of atrial fibrillation and acute coronary syndrome. However, the drug-drug interaction between them is still unknown.

Objective: To investigate the effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats both and .

Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease.

The diagnosis of frailty is usually subjective, which calls for objective biomarkers in clinical medicine. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn) and 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) in urine are two aging biomarkers that have not been explored deeply in cases of frailty. A total of 508 elderly patients with cardiovascular disease (mean age 75.

Scalable In-Fiber Manufacture of Functional Composite Particles.

Advanced fabrication methods must be developed for magnetic-polymeric particles, which are used in medical diagnostics, drug delivery, separation, and environmental remediation. The development of scalable fabrication processes that enables simultaneously tuning of diameters and compositions of magnetic-polymeric particles remains a major challenge. Here, we proposed the production of high-quality magnetic-composite particles through a universal method based on the in-fiber Plateau-Rayleigh instability of polymeric fibers.

Suppression of Laccase 2 severely impairs cuticle tanning and pathogen resistance during the pupal metamorphosis of Anopheles sinensis (Diptera: Culicidae).

Background: Phenol oxidases (POs) catalyze the oxidation of dopa and dopamine to melanin, which is crucial for cuticle formation and innate immune maintenance in insects. Although, Laccase 2, a member of the PO family, has been reported to be a requirement for melanin-mediated cuticle tanning in the development stages of some insects, whether it participates in cuticle construction and other physiological processes during the metamorphosis of mosquito pupae is unclear.

Methods: The association between the phenotype and the expression profile of Anopheles sinensis Laccase 2 (AsLac2) was assessed from pupation to adult eclosion.

Tyrosine Hydroxylase is crucial for maintaining pupal tanning and immunity in Anopheles sinensis.

Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzyme during mosquito development. In the current study, silencing of AsTH during the time period of continuous high expression in Anopheles sinensis pupae led to significant impairment of cuticle tanning and thickness, imposing a severe obstacle to eclosion in adults.

MR image super-resolution reconstruction using sparse representation, nonlocal similarity and sparse derivative prior.

In magnetic resonance (MR) imaging, image spatial resolution is determined by various instrumental limitations and physical considerations. This paper presents a new algorithm for producing a high-resolution version of a low-resolution MR image. The proposed method consists of two consecutive steps: (1) reconstructs a high-resolution MR image from a given low-resolution observation via solving a joint sparse representation and nonlocal similarity L1-norm minimization problem; and (2) applies a sparse derivative prior based post-processing to suppress blurring effects.