Clinical treatment of diabetic refractory ulcers is impeded by chronic inflammation and cell dysfunction associated with wound healing. The significant clinical application of bFGF in wound healing is limited by its instability . Sulfur has been applied for the treatment of skin diseases in the clinic for antibiosis.
View Article and Find Full Text PDFShark cartilage was created as a cancer-fighting diet because it was believed to have an element that may suppress tumor growth. Due to overfishing, sharks have become endangered recently, making it impossible to harvest natural components from shark cartilage for therapeutic development research. Previously, we identified a peptide SAIF from shark cartilage with an-tiangiogenic and anti-tumor effects, successfully expressed it in by using genetic engineering techniques.
View Article and Find Full Text PDFBioengineering (Basel)
June 2023
Peptides pose a challenge in drug development due to their short half-lives in vivo. In this study, we conducted in vitro degradation experiments on SAIF, which is a shark-derived peptide that we previously studied. The degradation fragments were sequenced and a truncated peptide sequence was identified.
View Article and Find Full Text PDFPharmaceuticals (Basel)
April 2023
Liver fibrosis represents a significant health hazard with a high morbidity rate and an increased risk of liver cancer. Targeting overactivated Fibroblast growth factor receptor 2 (FGFR2) is a promising strategy to counteract collagen accumulation during liver fibrosis. However, there is a shortage of drugs to specifically block the activation of FGFR2 in liver fibrosis patients.
View Article and Find Full Text PDFFlocculation is an important pretreatment technology for sludge dewatering, and the flocculant's performance is the key factor to determine the flocculation effect. Cationic polyacrylamide (CPAM) is commonly used in dewatering and conditioning of printing and dyeing sludge (PD sludge), and the research of high-efficiency flocculant is a hot spot in the field of PD sludge dewatering. Hydrophobic butylacrylate (BA) and (2-(Methacryloyloxy)ethyl) trimethylammonium chloride (DMC) were introduced into the copolymer, and amphiphilic (hydrophilic/lipophilic) CPAM, namely TP-ADB, with microblock structure was synthesized by ultrasonic initiated template copolymerization in this study.
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