MGFusion: a multimodal large language model-guided information perception for infrared and visible image fusion.

Existing image fusion methods primarily focus on complex network structure designs while neglecting the limitations of simple fusion strategies in complex scenarios. To address this issue, this study proposes a new method for infrared and visible image fusion based on a multimodal large language model. The method proposed in this paper fully considers the high demand for semantic information in enhancing image quality as well as the fusion strategies in complex scenes.

Penpulimab and Anlotinib in PDL1 high-expression pulmonary giant cell carcinoma with cerebral metastases: case report and review.

Pulmonary giant cell carcinoma (PGCC) is a rare subtype of non-small cell lung cancer (NSCLC) characterized by complex pathology, high rates of misdiagnosis or missed diagnosis, an aggressive clinical course, rapid progression, and poor prognosis. This case report describes a 67-year-old Chinese male with a left upper lobe lung mass, diagnosed CT-guided lung biopsy as PGCC with symptomatic multiple cerebral metastases. The tumor showed strong PD-L1 positivity, and genetic testing revealed a TP53 exon 4 c.

Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-κB signaling.

Aims: Cerebral aneurysm (CA) has been considered one of the most common cerebrovascular diseases, affecting millions of people worldwide. A therapeutic agent is currently missing for the treatment of CA. Nesfatin-1 (Nes-1) is an 82-amino acid adipokine which possesses a wide range of biological functions.

The dissociation of HO on the-U (110) and (100) surfaces: anstudy.

The dissociation of HO on-U (110) and-U (100) surfaces has been studied by usingmolecular dynamics simulations at an elevated temperature of 800 K. The simulation results show the dissociation of HO into the OH group and H atom, which are finally adsorbed on the uranium surface. The dissociation results from electronic interactions between surface uranium 6d/5 f states and the s orbitals of H and the 2p orbitals of O.

Context-aware lightweight remote-sensing image super-resolution network.

In recent years, remote-sensing image super-resolution (RSISR) methods based on convolutional neural networks (CNNs) have achieved significant progress. However, the limited receptive field of the convolutional kernel in CNNs hinders the network's ability to effectively capture long-range features in images, thus limiting further improvements in model performance. Additionally, the deployment of existing RSISR models to terminal devices is challenging due to their high computational complexity and large number of parameters.

New insights into the distribution and interaction mechanism of microplastics with humic acid in river sediments.

Information on the distribution and interaction of microplastics (MPs) and humic acids (HAs) in river sediment has not been fully explored. This study assessed the distribution and interaction of MPs with HAs at different depths in river sediments. The results delineated that the average abundance of MPs in the 0-10 cm layer (190 ± 20 items/kg) was significantly lower than that in the 11-20 cm and 21-30 cm layers (211 ± 10 items/kg and 238 ± 18 items/kg, respectively).

Solution-processed whispering-gallery-mode microsphere lasers based on colloidal CsPbBrperovskite nanocrystals.

Perovskite nanocrystals (NCs) have emerged as attractive gain materials for solution-processed microlasers. Despite the recent surge of reports in this field, it is still challenging to develop low-cost perovskite NC-based microlasers with high performance. Herein, we demonstrate low-threshold, spectrally tunable lasing from ensembles of CsPbBrNCs deposited on silica microspheres.

LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10.

Long non-coding RNAs are essential regulators of the inflammatory response, especially for transcriptional regulation of inflammatory genes. It has been reported that the expression of transmembrane channel-like 3 (TMC3)-AS1 is increased following lipopolysaccharide stimulation. However, the potential function of TMC3-AS1 in immunity is largely unknown.

A Long Noncoding RNA, Antisense IL-7, Promotes Inflammatory Gene Transcription through Facilitating Histone Acetylation and Switch/Sucrose Nonfermentable Chromatin Remodeling.

Long noncoding RNAs are important regulators of gene expression in innate immune responses. Antisense IL-7 (IL-7-AS) is a newly discovered long noncoding RNA in human and mouse that has been reported to regulate the expression of IL-6. However, the potential function of IL-7-AS in innate immune system is not fully understood.

The NF-κB-Responsive Long Noncoding RNA FIRRE Regulates Posttranscriptional Regulation of Inflammatory Gene Expression through Interacting with hnRNPU.

Long noncoding RNAs, a newly identified class of noncoding RNAs, are important regulators of gene expression in innate immunity. We report in this study that the transcription of FIRRE, a conserved long noncoding RNA between humans and mice, is controlled by NF-κB signaling in macrophages and intestinal epithelial cells. Functionally, FIRRE appears to positively regulate the expression of several inflammatory genes in macrophages or intestinal epithelial cells in response to LPS stimulation via posttranscriptional mechanisms.

Proteolytic activation of pro-macrophage-stimulating protein by hepsin.

Macrophage-stimulating protein (MSP) is a plasminogen-related growth factor and ligand for the receptor tyrosine kinase RON. The MSP/RON system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response. MSP binding to RON requires proteolytic conversion of the inactive single-chain form (pro-MSP) into the disulfide-linked α/β heterodimer.

Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

Although the signal transduction mechanisms of the receptor tyrosine kinase MET are well defined, less is known about its close relative RON. MET initiates intracellular signaling by autophosphorylation on specific cytoplasmic tyrosines that form docking sites for the adaptor proteins Grb2 and Gab1. Grb2 binds directly and is essential for all of the biological activities of MET.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to identify cDNA clones encoding putative secreted proteins. A second strategy utilized various algorithms that recognize features such as the hydrophobic properties of signal sequences to identify putative proteins encoded by expressed sequence tags (ESTs) from human cDNA libraries.

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23.

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.

The angiopoietin family of secreted factors is functionally defined by the C-terminal fibrinogen (FBN)-like domain, which mediates binding to the Tie2 receptor and thereby facilitates a cascade of events ultimately regulating blood vessel formation. By screening expressed sequence tag data bases for homologies to a consensus FBN-like motive, we have identified ANGPTL3, a liver-specific, secreted factor consisting of an N-terminal coiled-coil domain and the C-terminal FBN-like domain. Co-immunoprecipitation experiments, however, failed to detect binding of ANGPTL3 to the Tie2 receptor.