Arene-Cucurbiturils: Benzene-Containing Cucurbituril[2,4] and Benzene-Containing Cucurbituril[3,6].

Benzene-containing cucurbituril[2,4] and benzene-containing cucurbituril[3,6], the structures of cucurbit[]urils with some glycoluril units replaced by benzene rings, are constructed through condensation of specific benzene-containing motifs. These novel macrocycles inherit cucurbit[]urils' concave cavity and provide chemical modification potentiality and chromophores. Benzene-containing cucurbituril[2,4] shows a -symmetric macrocycle, while benzene-containing cucurbituril[3,6] exhibits a distinctive two-cavity structure (one big and one small) that resembles a gourd and could potentially accommodate two guests different in size simultaneously.

Dexmedetomidine Attenuated Neuron Death, Cognitive Decline, and Anxiety-Like Behavior by Inhibiting CXCL2 in CA1 Region of AD Mice.

Purpose: β-amyloid overload-induced neuroinflammation and neuronal loss are key pathological changes that occur during the progression of Alzheimer's disease (AD). Dexmedetomidine (Dex) exhibits neuroprotective and anti-inflammatory effects on the nervous system. However, the effect of Dex in AD mice remains unclear, and its neuroprotective regulatory mechanism requires further investigation.