Widespread detection in soils and sediments underscores the potential threats posed by persistent, bioaccumulative and toxic perfluorooctane sulfonate (PFOS) to ecosystems and organisms. Nevertheless, the formidable energy of the C-F bond imparts stability and hampers degradation. This study investigates the potential of boron carbide (BC), a hard-ceramic material often utilized in armor and abrasion contexts, for degrading solid-phase PFOS through ball milling.
View Article and Find Full Text PDFAutomated clinical coding (ACC) has emerged as a promising alternative to manual coding. This study proposes a novel human-in-the-loop (HITL) framework, CliniCoCo. Using deep learning capacities, CliniCoCo focuses on how such ACC systems and human coders can work effectively and efficiently together in real-world settings.
View Article and Find Full Text PDFBackground: Dengue fever poses a significant global public health concern, necessitating the monitoring of Aedes mosquito population density. These mosquitoes serve as the disease vectors, making their surveillance crucial for dengue prevention. The objective of this study was to address the difficulty associated with identifying and counting mosquito eggs of wild strains during the monitoring of Aedes albopictus (Diptera: Culicidae) density via ovitraps in field surveys.
View Article and Find Full Text PDFBackground: Stroke ranks as the second leading cause of death worldwide. Meanwhile, headaches are considered the second leading cause of disability, and they often occur as a stroke complication. However, insufficient attention has been given to the treatment and rehabilitation of headaches among stroke patients, and the research on the epidemiology and risk factors of headaches in stroke patients in China is limited.
View Article and Find Full Text PDFThis study investigates the mass sensitivity of a quartz crystal microbalance (QCM) with a circular symmetric electrode (M-M type) operating in the third overtone mode and finds that its central mass sensitivity is nearly five times greater than that of the fundamental mode, as determined through a deposition experiment, rather than the three times greater central mass sensitivity predicted by classical theory. The reasons for this phenomenon were determined through a combination of theoretical calculation and finite element simulation. The results revealed that (1) compared with the fundamental mode, the third overtone mode exhibits a more pronounced energy trapping effect, leading to a sharper mass sensitivity distribution and a more concentrated sensitivity in the central region and (2) the third overtone resonance frequency is slightly higher than three times the fundamental resonance frequency.
View Article and Find Full Text PDFTunnels in the Western Plateau region of China often face numerous problems of high ground stress, as well as highly fractured and weak rock masses in deep sections of the tunnel, which results in an increased risk of large soft rock deformation in tunnels, posing substantial challenges to safe and efficient construction. Hence, risk assessment and establishment of an early safety warning system are essential. By examining factors affecting the large soft rock deformation in tunnels, a set of index system consisting of three primary indicators (i.
View Article and Find Full Text PDFOptimizing the transmit light beams unlocks the full potential of free-space optical systems. However, designing application-specific light beams remains a challenge, especially for those traversing random media. In this study, we address this gap by proposing a deep learning-based method to generate optimal beams for propagation through atmospheric turbulence.
View Article and Find Full Text PDFKnowledge of the biotransformation of tetrabromobisphenol A (TBBPA) and its related contaminants by human gut microbiota (GM) remains unexplored. Here, TBBPA and its four analogs were incubated with mixed GM strains, and nine rhamnosylated or debrominated transformation products (TPs) were discovered. Remarkably, rhamnosylation was identified as a common and unique microbial transformation pathway for these contaminants, and six of the seven rhamnosylated TPs were reported for the first time.
View Article and Find Full Text PDFFoundation model, trained on a diverse range of data and adaptable to a myriad of tasks, is advancing healthcare. It fosters the development of healthcare artificial intelligence (AI) models tailored to the intricacies of the medical field, bridging the gap between limited AI models and the varied nature of healthcare practices. The advancement of a healthcare foundation model (HFM) brings forth tremendous potential to augment intelligent healthcare services across a broad spectrum of scenarios.
View Article and Find Full Text PDFBackground: Previous studies have reported the link between hypoxic conditions and NLRP3 inflammasome-mediated pulpal inflammation in the progression of pulpitis. However, the underlying mechanism has not been fully elucidated. This study aimed to investigate the role of HIF-1α in the regulation of NLRP3 inflammasome pathway via NF-κB signaling under hypoxic conditions with or without LPS in human dental pulp fibroblasts (HDPFs) during the progression of pulpitis.
View Article and Find Full Text PDFSemi-interpenetrating polymer networks (SIPNs) have garnered significant interest due to their potential applications in self-healing materials, drug delivery systems, electrolytes, functional membranes, smart gels and, toughing. SIPNs combine the characteristics of physical cross-linking with advantageous chemical properties, offering broad application prospects in materials science and engineering. This perspective introduces the history of semi-interpenetrating polymer networks and their diverse applications.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) is a common metabolic disease that adversely impacts patient health. In this study, a T2DM model was established in ICR mice through the administration of a high-sugar and high-fat diet combined with the intraperitoneal injection of streptozotocin to explore the hypoglycemic effect of polysaccharides from L. After six weeks of treatment, the mice in the high-dosage group (800 mg/kg bw) displayed significant improvements in terms of fasting blood glucose concentration, glucose tolerance, serum insulin level, insulin resistance, and weight loss ( < 0.
View Article and Find Full Text PDFAmbitious action plans have been launched to address climate change and air pollution. Through coupling the IMED|CGE, GAINS, and IMED|HEL models, this study investigate the impacts of implementing carbon neutrality and clean air policies on the energy-environment-health-economy chain in the Beijing-Tianjin-Hebei-Henan-Shandong-Shanxi region of China. Results show that Shandong holds the largest reduction in energy consumption and carbon emissions toward the 1.
View Article and Find Full Text PDFGastric cancer is a common heterogeneous tumor. Most patients have advanced gastric cancer at the time of diagnosis and often need chemotherapy. Although 5-fluorouracil (5-FU) is widely used for treatment, its therapeutic sensitivity and drug tolerance still need to be determined, which emphasizes the importance of individualized administration.
View Article and Find Full Text PDFExtensive application of rare earth element oxide nanoparticles (REE NPs) has raised a concern over the possible toxic health effects after human exposure. Once entering the body, REE NPs are primarily processed by phagocytes in particular macrophages and undergo biotic phosphate complexation in lysosomal compartment. Such biotransformation affects the target organs and in vivo fate of REE NPs after escaping the lysosomes.
View Article and Find Full Text PDFAs a booming branch of online retailing, live-streaming e-commerce can present abundant information dimensions and diverse forms of expression. Live-streaming e-commerce has enabled online retailers to interact with customers face-to-face, resulting in widespread instances of emotional and impulse buying behavior. Prior research in live-streaming e-commerce has suggested that live streamers' characteristics, especially the live streamer's face, can affect customers' purchase intentions.
View Article and Find Full Text PDFBackground: Without timely and effective rehabilitation, hearing loss may profoundly affect human life quality. China has a large population of hearing-impaired individuals, which imposes a heavy health burden on society. Moreover, this population is projected to increase rapidly owing to China's aging society.
View Article and Find Full Text PDFAedes albopictus (Diptera: Culicidae) plays a crucial role as a vector for mosquito-borne diseases like dengue and zika. Given the limited availability of effective vaccines, the prevention of Aedes-borne diseases mainly relies on extensive efforts in vector surveillance and control. In multiple mosquito control methods, the identification and elimination of potential breeding sites (PBS) for Aedes are recognized as effective methods for population control.
View Article and Find Full Text PDFPlatinum (Pt) supported on high surface area carbon has been the most widely used electrocatalyst in proton exchange membrane fuel cell (PEMFC). However, conventional carbon supports are susceptible to corrosion at high potentials, leading to severe degradation of electrochemical performance. In this work, titanium carbonitride embedded in mesoporous carbon nanofibers (m-TiCN NFs) are reported as a promising alternative to address this issue.
View Article and Find Full Text PDFMillimeter-wave (mmWave) massive multiple-input multiple-output non-orthogonal multiple access (MIMO-NOMA) is proven to be a primary technique for sixth-generation (6G) wireless communication networks. However, the great increase in users and antennas brings challenges for interference suppression and resource allocation for mmWave massive MIMO-NOMA systems. This study proposes a spectrum-efficient and fast convergence deep reinforcement learning (DRL)-based resource allocation framework to optimize user grouping and allocation of subchannel and power.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
April 2024
Based on the spatially correlated effects of air pollution on regional innovation, theoretical hypotheses are proposed, and this paper employs a spatial Durbin model to conduct empirical tests using panel data from 267 Chinese cities from 2003 to 2019, and investigates the mediating effect of human capital. Research has shown that (1) air pollution significantly reduces regional innovation output and has a negative spatial spillover effect significantly in the short term; (2) in the process of regional innovation impacted by air pollution, human capital acts as a mediator role; and (3) analysis of heterogeneity reveals that, from the regional perspective, air pollution has significantly damaged regional innovation in eastern and middle cities, but not significantly influences western cities, and in terms of innovation types, there is a stronger detrimental effect on invention patents exerted by air pollution compared to non-innovation patents. The study's findings provide theoretical and empirical evidence to strengthen environmental governance, enhance regional innovation and promote the coordinated development of regional innovation.
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