Surface Plasmon Resonance-Enhanced CdS/FTO Heterojunction for Cu Detection.

Copper ion (Cu) pollution poses a serious threat to marine ecology and fisheries. However, the complexity of seawater and its interference factors make the online detection of Cu quite challenging. To address this issue, we introduce the concept of the photo-assisted adjustment barrier effect into electrochemical detection, using it as a driving force to generate electrochemical responses.

Preparation of hollow double-layer Pt@CeO nanospheres as oxidase mimetics for the colorimetric-fluorescent-SERS triple-mode detection of glutathione in serum.

Glutathione (GSH) is an essential antioxidant in the human body, but its detection is difficult due to the interference of complex components in serum. Herein, hollow double-layer Pt@CeO nanospheres were developed as oxidase mimetics, and the light-assisted oxidase mimetics effects were found. The oxidase activity was enhanced significantly by utilizing the synergistic effect of Schottky junction and the localized surface plasmon resonance (LSPR) of Pt under UV light.

Using the Photo-Piezoelectric Effect of AuPt@BaTiO Oxidase Mimetics for Colorimetric Detection of GSH in Serum.

Nanozymes possess major advantages in catalysis and biosensing compared with natural nanozymes. In this study, the AuPt@BaTiO bimetallic alloy Schottky junction is prepared to act as oxidase mimetics, and its photo-piezoelectric effect is investigated. The synergy between the photo-piezoelectric effect and the local surface plasmon resonance enhances the directional migration and separation of photogenerated electrons, as well as hot electrons induced by the AuPt bimetallic alloy.

Using Multistage Energy Barrier of Heterojunctions in Improving Cr(VI) Detection.

Detecting heavy metals in seawater is challenging due to the high salinity and complex composition, which cause strong interference. To address this issue, we propose using a multistage energy barrier as an electrochemical driver to generate electrochemical responses that can resist interference. The Ni-based heterojunction foams with different types of barriers were fabricated to detect Cr(VI), and the effects of the energy barriers on the electrochemical response were studied.

Using the photo-enhanced barrier effect on electrochemical response for highly sensitive detection of melamine.

Melamine added to milk powder can lead to kidney injury and even death, but rapid detection is still hard due to the strong interference of milk powder solution. Herein, the CC/CeO/CNPs mesh was constructed to detect melamine by using the photo-enhanced barrier effects on electrochemical response. Schottky barrier was regulated effectively to produce electrochemical response to melamine by photo-induced electrostatic interaction, which exhibited strong resistance to interference in milk powder solution.

Novel pathogenic variants in the androgen receptor gene associated with androgen insensitivity syndrome identified through exome sequencing and in silico analysis.

Androgen insensitivity syndrome (AIS) is a common disorder/differences of sex development with a 46, XY karyotype, but diverse genital phenotypes. Various pathogenic variants within the androgen receptor (AR) gene on the X chromosome are the primary pathogenesis of AIS. However, some patients with AIS still lack a definitive molecular diagnosis.

Plasmonic Array at the Liquid-Liquid Interface: A Dual-Mode Optical Sensing Platform for Multianalytes.

Analyte-triggered nanoparticle (NP) assemblies in bulk colloidal suspension have been extensively utilized in various optical sensors. Nevertheless, the assembling process is still limited by the slow diffusion dynamics of NPs and the low concentration of analytes in trace detections, which hinders further improvement of the sensitivity and repeatability of the sensors. In this work, by functionalizing the gold NPs with specific ligands, we constructed a dual-mode optical sensing platform for multianalytes based on the plasmonic NP array at the liquid-liquid interface.

The construction and destruction of gold nanoparticle assembly at liquid-liquid interface for Cd sensing.

The analyte-induced aggregation of plasmonic nanoparticles (NPs) in the bulk solution have been widely employed in optical sensors. However, in trace detection, the slow diffusion kinetics of NPs and the ultralow concentration of analytes significantly limit the binding opportunity of the analytes, thus impose penalties on the sensitivity, reproducibility and response time of the sensors. Herein, we propose a novel sensing method with two working modes that based on the construction/destruction of NP arrays at the liquid-liquid interface (LLI).

Dual-Modulated Heterojunctions for Anti-Interference Sensing of Heavy Metals in Seawater.

Trace analyte detection in a complex environment such as in seawater is usually challenging for classic redox-based electrochemical sensors since the matrix effect of high salinity and various interfering species with similar redox properties can generate false positive/negative signals, thus impacting the sensitivity and specificity of the sensors. In this work, unlike redox-based approaches, we propose a novel sensing mode that relies on dual-modulated interfacial energy barriers of heterojunctions. By constructing the hierarchical structure of Ni/TiO/porous-reduced graphene oxide/chitosan (CS), we introduce interfacial energy barriers of Schottky junctions into the electrochemical sensors for Cu.

Ion-bearing stairs: alkali metal complexes of 1,2-diaza-4-phospholides.

In this work, eight alkali metal complexes with 1,2-diaza-4-phospholide ligands were prepared and characterized by X-ray single-crystal structural analysis and NMR spectroscopy. Their structures showed varied coordination motifs: (i) a dimeric 1,2-diaza-4-phospholide lithium complex with -bidentate bridging coordination (4) consists of two lithium atoms that are linked two μ-bridging, κ,κ-coordinated ligands; (ii) the polymeric chain 1,2-diaza-4-phospholide potassium complex (5) showed an ion-bearing stair-shaped chain structure running through axis , where the steps are η interactions, and there is a transition platform between every two stairs; (iii) the polymeric chain 1,2-diaza-4-phospholide potassium complex (6) also presented a polymeric chain structure in the solid state but displayed a head-to-tail arrangement of two 1,2-diaza-4-phospholides; (iv) in comparison to 6, the 1,2-diaza-4-phospholide sodium complex (7) displayed a tetrameric structure, in which the sodium ions are arranged in a distorted tetrahedral fashion and each of them occupies a vertex of the tetrahedron; (v) the polymeric chain 1,2-diaza-4-phospholide potassium complex (8) presented a solvent-free chain structure, in which potassium ions each is η-bonded by two 1,2-diaza-4-phospholides and η-coordinated by another, consisting of a stair-shaped chain structure running through axis but without significant intermolecular contacts between the adjacent stairs in comparison to that of 5; (vi) the polymeric chain 1,2-diaza-4-phospholide sodium complex (9) presented a solvent-free chain structure, in which sodium ions each is η(),η(,),η()-bonded by three 1,2-diaza-4-phospholides, consisting of a chain structure running through axis ; and (vii) the treatment complex 8 with elemental sulphur or selenium in the presence of crown ether gave rare thiophosphonato potassium [η(,,)-3,5-Budp-(μ-K)(S)([18]crown-6)] (10) or a selenophosphonato potassium [η(,,)-3,5-Budp-(μ-K)(Se)([18]crown-6)] (11). Both of the complexes crystallized in the orthorhombic space group as pale-yellow (or red) crystals.

Using photo-induced p-n junction interface effect of CoMnO/β-MnO oxidase mimetics for colorimetric determination of hydroquinone in seawater.

Detection of pollutants in seawater faces a great challenge of strong interference, and the facile detection method is lacked. The CoMnO/β-MnO p-n junction oxidase mimetics were successfully prepared for colorimetric detection of hydroquinone in seawater. The catalysis ability was enhanced significantly by the photo-induced p-n junction interface effect.

Hypogonadotropic hypogonadism associated with another small supernumerary marker chromosome (sSMC) derived from chromosome 22, a case report.

The idiopathic hypogonadotropic hypogonadism (IHH) is portrayed as missing or fragmented pubescence, cryptorchidism, small penis, and infertility. Clinically it is characterized by the low level of sex steroids and gonadotropins, normal radiographic findings of the hypothalamic-pituitary areas, and normal baseline and reserve testing of the rest of the hypothalamic-pituitary axes. Delay puberty and infertility result from an abnormal pattern of episodic GnRH secretion.

Fabrication of the Ni-based composite wires for electrochemical detection of copper(Ⅱ) ions.

Copper ions (Cu) pollution in the water environment poses a great threat to the health function of life-sustaining metabolic activities. However, the current detection methods need relatively expensive instruments, complex operation procedures and long time, so a facile and direct detection method is desired to be developed. In this work, the Ni-based composite wires with p-n junction (the Ni/NiO/ZnO/Chitosan wire) and Schottky junction (the Ni/NiO/Au/Chitosan wire) were fabricated, and the barrier driven electrochemical sensing mechanism was studied.

1,2,4-Triazolato paddlewheel dibismuth complexes with very short Bi(II)-Bi(II) bonds: bismuth(III) oxidation of 1,2,4-triazolato anions into neutral -1,2,4-triazolyl radicals.

Bismuth(iii) oxidation of 3,5-di-substituted-1,2,4-triazolato anions afforded a paddlewheel 1,2,4-triazolato dibismuth complex [L2(Bi-Bi)L2] (L = η1,η1-3,5-R2tz, R = Ph (3), iPr (4)) with very short Bi(ii)-Bi(ii) bonds (2.8650(4)-2.8721(3) Å).

Construction of hierarchical 2D/2D TiC/MoS nanocomposites for high-efficiency solar steam generation.

Solar steam generation has been considered one of the most promising approaches for dealing with the energy and freshwater resource crises in recent years. However, achieving high efficiency in photo-thermal conversion remains a considerable challenge. Here, a series of hierarchical TiC/MoS nanocomposites were designed for steam generation by a hydrothermal method.

Preparation of NiMnO/C necklace-like microspheres as oxidase mimetic for colorimetric determination of ascorbic acid.

The NiMnO/C necklace-like microspheres (NLM) were successfully prepared by hydrothermal method and oil bath. This unique necklace-like structure makes them exhibit the enhanced intrinsic oxidase-like activity, as the special interface can help capture electrons from 3,3',5,5'-tetramethylbenzidine. The fabricated NiMnO/C NLM were successfully used as the high-performance oxidase mimetic to catalyze the oxidation of TMB directly for the color reaction.

Using the interfacial barrier effects of p-n junction on electrochemistry for detection of phosphate.

A novel type of electrochemical sensor for detection of phosphate in water environment was developed by combining the interfacial barrier of p-n junction with the adsorption of phosphate. The electrochemical response was produced by the induced change of the barrier height, which was only caused by the specific adsorption of phosphate. Two linear concentration ranges (0-0.

Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most aggressive cancers with a high rate of recurrence and metastasis. Trifluridine (TFT) is a thymidine analog to target thymidylate synthase (TS) and has potent ant-herpes simplex virus activity. However, little is known whether and how TFT treatment can modulate the growth of TNBC.

Fabrication of the Ni/ZnO/BiOI foam for the improved electrochemical biosensing performance to glucose.

The Ni foam decorated with ZnO/BiOI core-shell p-n junction nanorods was prepared and employed as an enzyme loading matrix to detect glucose. The detection potential was decreased significantly (0.3 V) and the sensitivity was enhanced largely (115.

Combined inorganic base promoted N-addition/[2,3]-sigmatropic rearrangement to construct homoallyl sulfur-containing pyrazolones.

The first sequentially combined inorganic base promoted N-addition/[2,3]-sigmatropic rearrangement reaction of α-alkylidene pyrazolinones and propargyl sulfonium salts has been reported to construct homoallyl sulfur-containing pyrazolones with moderate to excellent yields. α-Alkylidene pyrazolinones function as N-nucleophilic agents distinguished from the reported C-addition reactions. Propargyl sulfonium salts were first involved in the [2,3]-sigmatropic rearrangement protocol differentiated from the well-established annulation reactions.

Regioselective N-Addition/Substitution Reaction of α-Alkylidene Pyrazolinones with Propargyl Sulfonium Salts to Construct Allylthio-Containing Pyrazolones.

The regioselective N-addition/substitution reaction between α-alkylidene pyrazolinones and propargyl sulfonium salts has been developed to construct functionalized allylthio-containing pyrazolones with moderate to excellent yields. α-Alkylidene pyrazolinones act as N-nucleophilic agents which are distinguished from reported C-nucleophilic reactions. Excellent regioselectivity, readily available starting materials, the broad range of substrates, gram-scale synthesis, and simple operation illustrate the synthetic advantages of this new reaction pathway.

Novel pathogenic mutations in disorders of sex development associated genes cause 46,XY complete gonadal dysgenesis.

Disorders of sex development (DSDs) are congenital conditions in which chromosomal, gonadal and sex is atypical. It is difficult to diagnose and manage patients with DSD in clinical practice, and the molecular etiology of DSD is still not completely understood. Here, we identified two novel pathogenic mutations from three unrelated Chinese patients with 46,XY complete gonadal dysgenesis (CGD) that is a clinical subgroup of DSD by whole exome sequencing.

Fabrication of CQDs/MoS/Mo foil for the improved electrochemical detection.

We proposed a new method for regulating the electrochemical signal by using Schottky barrier. The results show that the height of Schottky barrier can be altered by adsorbing charged substance to control the enhancement and attenuation of electrochemical signal. The Schottky interface formed by MoS and CQDs (carbon quantum dots) can achieve the selective detection of dopamine and overcome the distraction of ascorbic acid and uric acid with similar redox signal.

Auxetic Thermoresponsive Nanoplasmonic Optical Switch.

Development and use of metamaterials have been gaining prominence in large part due to the possibility of creating platforms with "disruptive" and unique optical properties. However, to date, the majority of such systems produced using micro or nanotechnology are static and can only perform certain target functions. Next-generation multifunctional smart optical metamaterials are expected to have tunable elements with the possibility of controlling the optical properties in real time via variation in parameters such as pressure, mechanical stress, and voltage or through nonlinear optical effects.