Publications by authors named "Mingfang Bi"

is an important zoonotic Gram-positive bacterium that appears in chains, without spores or flagella, and belongs to the . It can be transmitted through droplets or contact, with the preferred antibiotics being penicillin, erythromycin, or cephalosporins. However, the misuse of these drugs has led to antibiotic resistance, posing a significant threat to both human and animal health.

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Article Synopsis
  • - The study focuses on the impact of porcine circoviruses, especially PCV2 and PCV3, on the pig industry in Xinjiang, noting their high prevalence and harmful effects compared to PCV1 and PCV4, which are less common.
  • - Researchers collected and analyzed samples from 453 deceased pigs in Xinjiang between 2022 and 2024, revealing positive detection rates of 15% for PCV1, 71% for PCV2, 25% for PCV3, and 17% for PCV4, along with important genetic insights.
  • - The findings contribute to understanding porcine circovirus distribution and evolution, highlighting variability in PCV2 and stability in PCV3, and
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Spacer acquisition step in CRISPR-Cas system involves the recognition and subsequent integration of protospacer by the Cas1-Cas2 complex in CRISPR-Cas systems. Here we report an anti-CRISPR protein, AcrVA5, and reveal the mechanisms by which it strongly inhibits protospacer integration. Our biochemical data shows that the integration by Cas1-Cas2 was abrogated in the presence of AcrVA5.

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The recently identified pathogenic Porcine circovirus type 3 (PCV3) may threaten to reduce the pig population dramatically worldwide. In our previous study, a PCV3-specific monoclonal antibody (mAb-1H11) was successfully applied in immune-histochemistry staining and ELISA, which specifically recognize PCV3 capsid protein in PCV3-positive pig tissues. In the present study, we expressed and purified the soluble sole capsid protein of PCV3.

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