Publications by authors named "Mingduo Liu"
Article Synopsis
- Minimally invasive thermal therapy, like microwave ablation (MWA), has high success rates in treating solid tumors but faces challenges with tumor recurrence.
- Research indicates that while MWA slightly increases the memory phenotype of peripheral CD8 T cells, their metabolism is still not ideal for sustaining long-term immunity.
- Combining MWA with glycolysis inhibition using 2-deoxy-D-glucose may enhance the differentiation of CD8 T cells, providing a promising strategy to improve outcomes and reduce the risk of tumor recurrence in future clinical trials.
Metastasis is the major cause of cancer-related death, and lymph node is the most common site of metastasis in breast cancer. However, the alterations that happen in tumor-draining lymph nodes (TDLNs) to form a premetastatic microenvironment are largely unknown. Here, we first report the dynamic changes in size and immune status of TDLNs before metastasis in breast cancer.
View Article and Find Full Text PDFBackground: Immune checkpoint blockade has shown low response rates for advanced breast cancer, and combination strategies are needed. Microwave ablation (MWA) may be a trigger of antitumor immunity. This window-of-opportunity trial (ClinicalTrials.
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