Microstructure and Mechanical Properties of As-Cast Al-10Ce-3Mg-xZn Alloys.

The microstructure and mechanical properties of as-cast Al-10Ce-3Mg-xZn (x = 0, 1, 3, 5 wt.%) alloys were systematically investigated, with a focus on the effect of Zn on the AlCe reinforcing phase in the alloy. The results showed that the Al-10Ce-3Mg alloy consists of α-Al, a Chinese-script AlCe eutectic phase, and a massive AlCe primary phase.

Effect of Combined Addition of CeLa and GdY on Microstructure and Mechanical Properties of As-Cast Al-Cu-Mn Alloys.

In this study, the effects of the combined addition of CeLa and GdY on the microstructure and mechanical properties of as-cast Al-4Cu-1Mn alloys were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and tensile testing. The results show that the minor addition of CeLa and GdY leads to a refinement of grain size. The addition of CeLa results in the formation of supersaturated vacancies in the Al matrix, whereas the addition of GdY leads to a decrease in the precipitation temperature of the AlCu phase.

Effects of Beryllium Addition on Microstructure, Mechanical and Corrosion Performance of Al-Mg-Li Alloys.

The Al-Mg-Li alloy is ideal for ultra-lightweight aircraft components, and its further performance improvement is of great interest in the aerospace industry. In this study, the effects of various beryllium (Be) additions (Be-free, 0.1, 0.

Comparison of the efficacy and safety between rivaroxaban and dabigatran in the treatment of acute portal vein thrombosis in cirrhosis.

Background: New oral anticoagulants (NOACs) have been becoming prevalent in recent years and are increasingly used in the treatment of port vein thrombosis. The difference of the efficacy and safety between rivaroxaban and dabigatran remains unclear in the treatment of cirrhotic patients with acute portal vein thrombosis (PVT).

Methods: This retrospective study included all consecutive cirrhotic patients with acute portal vein thrombosis in our institute from January 2020 to December 2021.

Physical and mental health impairments experienced by operating surgeons and camera-holder assistants during laparoscopic surgery: a cross-sectional survey.

Introduction: Surgeons may experience physical and mental health problems because of their jobs, which may lead to chronic muscle damage, burnout, or even withdrawal. However, these are often ignored -holder assistants during laparoscopic surgery. We aimed to analyze the differences between operating surgeons and camera-holder assistants.

An Autophagy-Associated MITF-GAS5-miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis.

Background: Sepsis induces GAS5 expression in the vascular endothelium, but the molecular mechanism is unclear, as is the role of GAS5 in sepsis.

Methods And Results: We observed that GAS5 expression in the endothelium was significantly upregulated in a sepsis mouse model. ChIP-PCR and EMSA confirmed that the oxidative stress (OS)-activated MiT-TFE transcription factor (MITF, TFE3, and TFEB)-mediated GAS5 transcription.

Strategies involving low-molecular-weight heparin for the treatment and prevention of venous thromboembolism in patients with obesity: A systematic review and meta-analysis.

Introduction: Recent studies have indicated that the dosage of LMWH in patients with specific weights may be controversial. Therefore, we conducted a meta-analysis to explore an appropriate dosage of LMWH for the prevention and treatment of venous thromboembolism (VTE) in patients with obesity.

Materials And Methods: We searched the PubMed, EMBASE, and Cochrane Library databases up to July 23, 2022.

Effect of Rolling Temperature on Microstructure and Properties of Al-Mg-Li Alloy.

In this study, the effects of hot-rolled processes at different temperatures (420 °C, 450 °C, and 480 °C) and subsequent solid solution and aging treatments on the microstructure, mechanical properties, and corrosion properties of Al-Mg-Li alloys with trace Sc and Zr addition were investigated. The aging treatment of rolled sheets after solid solution treatment could obtain AlLi particles and Al(Sc, Zr)/AlLi core-shell particles to improve the mechanical properties of Al-Mg-Li alloy products effectively. The results showed that, as the rolling temperatures increased from 420 °C to 480 °C, the alloy's ultimate tensile strengths and yield strengths increased, while the corrosion resistance decreased.

Microstructure, Mechanical Properties and Corrosion Behaviors of Al-Li-Cu-Mg-Ag-Zn Alloys.

Combined with microstructure characterization and properties tests, the effects of Zn contents on the mechanical properties, corrosion behaviors, and microstructural evolution of extruded Al-Li-Cu-Mg-Ag alloys were investigated. The results show that the increase in Zn contents can accelerate hardening kinetics and improve the hardness of peak-aged alloys. The Zn-added alloys present non-recrystallization characteristics combined with partially small recrystallized grains along the grain boundaries, while the T1 phase with finer dimension and higher number density could explain the constantly increasing tensile strength.

Pharmacokinetic interaction study of combining imatinib with dasatinib in rats by UPLC-MS/MS.

This study examined whether oral administration of dasatinib to the rats with imatinib led to any pharmacokinetic interactions. Twenty-four rats were divided randomly into three groups, imatinib group (imatinib 25 mg/kg, n = 8), dasatinib group (dasatinib 15 mg/kg, n = 8) and co-administration group (dasatinib 15 mg/kg and imatinib 25 mg/kg, n = 8). The concentration of imatinib and dasatinib in rat plasma was determined by a sensitive and simple UPLC-MS/MS method.

Evaluation of the effect of apatinib (YN968D1) on cytochrome P450 enzymes with cocktail probe drugs in rats by UPLC-MS/MS.

An accurate and validated liquid chromatography method and a triple quadrupole mass spectrometry method were developed and validated to simultaneously evaluate the cytochrome P450 (CYP) enzymes in vivo using the co-administration of these probes. Phenacetin, losartan, metoprolol and midazolam were used as the probe substrates for rat CYP1A2, CYP2C11, CYP2D4 and CYP3A1 enzymes, respectively. The purpose of the study was to investigate the effect of apatinib on these cytochrome P450 enzymes in vivo with co-administration of these probes.

Herbal extract elemene intrathoracic injection in the treatment of lung cancer patients with malignant pleural effusion: a meta-anaylsis.

Objective: The aim of this study was to evaluate the clinical efficacy of elemene intrapleural injection in the treatment of lung cancer with malignant pleural effusion by meta-analysis.

Materials And Methods: PubMed (1960-2014.4), EMBASE (1980-2014.

The clinical value of Fufangkushen injection in the treatment of stomach cancer: a meta-analysis.

Objective: The purpose of this meta-analysis was to evaluate the effects of Fufangkushen injection combined with chemotherapy in the treatment of stomach cancer.

Materials And Methods: The relevant clinical trials about Fufangkushen injection combined with chemotherapy in the treatment of stomach cancer were search in the data bases of Pubmed, EMBASE, Cochran and CNKI. The data related to objective response rate, Karnofsky (KPS) score and toxicity were extracted and pooled using the Stata 11.