Publications by authors named "Mingdong Song"
Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant .
Front Cell Infect Microbiol
December 2024
Ceftazidime-avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA resistance, while its heteroresistance in CRKP remains poorly understood. This study aimed to investigate the characteristics and mechanisms of CZA heteroresistance in CRKP isolates.
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- Tigecycline (TGC) is used to treat carbapenem-resistant (CRAB) infections, while eravacycline (ERV) is a newer tetracycline that could provide additional treatment options, but their resistance mechanisms are not fully understood.
- A study analyzed 492 clinical isolates from hospitalized patients in China, comparing the resistance characteristics of ERV and TGC, finding that ERV generally had lower minimum inhibitory concentrations (MICs) than TGC.
- The results showed distinct resistance mechanisms, with certain genetic mutations and insertions contributing to the resistance; specifically, high expression levels in resistant strains were linked to the presence of insertions, impacting the effectiveness of both ERV and TGC