Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis.

Background: Mitochondrial dysfunction and damage can result in the release of mitochondrial DNA (mtDNA) into the cytoplasm, which subsequently activates the cGAS-STING pathway, promoting the onset of inflammatory diseases. Various factors, such as oxidative stress, viral infection, and drug toxicity, have been identified as inducers of mitochondrial damage. This study aims to investigate the role of mtDNA as a critical inflammatory mediator in the pathogenesis of ketamine (KET)-induced cystitis (KC) through the cGAS-STING pathway.

Rice husk biochar resuscitates the microecological functions of heavy-metal contaminated soil after washing by enriching functional bacteria.

Biochar has great potential for simultaneously improving soil ecological functions and eliminating environmental pollutants. However, studies on this strategy in the restoration of ecological functions in chelator-washed soil are lacking, and the effect of biochar on the structure, functions, and microbial interactions of washed soil microbiomes are unclear. Hence, the effect of rice husk biochar (RHB, 2 %) on the physicochemical properties, heavy metal fractions, and microbial community structure of glutamate-N, N-diacetic acid (GLDA)- and ethylenediaminetetraacetic acid (EDTA)- washed remediated soil were investigated.

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling.

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly expressed in dorsal root ganglion (DRG) neurons and functions as a Gαq-coupled G protein-coupled receptor (GPCR)-like receptor to sense noxious heat. TMC6-deficient mice display a substantial impairment in noxious heat sensation while maintaining normal perception of cold, warmth, touch, and mechanical pain.

Sunitinib for adenocarcinoma of the rete testis: a case report.

Background: Adenocarcinoma of the rete testis (AORT) is an extremely rare and aggressive tumor with a poor prognosis. Its etiology and pathological characteristics have not been extensively studied, making accurate diagnosis and appropriate management challenging. AORT, an invasive testicular tumor with a mortality rate of 46%, treatment typically involves radical orchiectomy, retroperitoneal pelvic lymph node dissection (RPLND), adjuvant chemotherapy, and/or ongoing monitoring, but the response to conventional radiation and chemotherapy is limited.

A Systematic Immune and Prognostic Analysis of CD48 Interaction with Tumor Microenvironment in Pan-Cancer.

Background: The cluster of differentiation 48 (CD48) is a member of the signaling lymphocyte activation molecule family, constitutively expressed on most hematopoietic cells. CD48 was reported to affect immune regulation in certain tumors, thereby influencing tumor development and prognosis, but its impact on the prognosis and immune infiltration in pan-cancer remains unclear.

Material And Methods: We systematically analyzed the raw data from The Cancer Genome Atlas (TCGA), Tumor Immune Estimation Resource (TIMER), and Tumor Immune Dysfunction and Exclusion (TIDE) databases.

Online Active Continual Learning for Robotic Lifelong Object Recognition.

In real-world applications, robotic systems collect vast amounts of new data from ever-changing environments over time. They need to continually interact and learn new knowledge from the external world to adapt to the environment. Particularly, lifelong object recognition in an online and interactive manner is a crucial and fundamental capability for robotic systems.