Publications by authors named "Mingbin Zhan"
Article Synopsis
- - The study explores the role of DLX5, a key transcription factor for bone cell differentiation, in the progression of ossification of the posterior longitudinal ligaments (OPLL) under mechanical stimulation (MS).
- - Researchers found that OPLL cells displayed significantly higher levels of DLX5 and osteogenic-related genes when subjected to stretch stimulation, unlike non-OPLL cells, indicating a difference in response to mechanical stress.
- - The findings suggest that the NOTCH signaling pathway mediates the increase in DLX5 during MS, contributing to the progression of OPLL, highlighting a potential target for understanding the disease's mechanisms.
Front Cell Dev Biol
July 2022
Article Synopsis
- * Research in aged mice showed that senolytics can rejuvenate vascular endothelial cells in the bone endplate, potentially improving nutrient transport to the IVD and reducing its degeneration.
- * Preliminary results indicate that senolytics decrease markers of cellular aging in endothelial cells, which could lead to better blood supply and overall health of the IVD.
