Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial.

Background: Addressing high-salt diets in China through interventions can significantly reduce blood pressure (BP) and the associated health risks.

Objective: This study aims to evaluate the effectiveness of a comprehensive salt reduction intervention implemented across counties in Zhejiang Province, focusing on system establishment, extensive publicity, and targeted population interventions.

Methods: The Salt Reduction and Hypertension Prevention Project was initiated in Zhejiang Province.

Prevalence and Risk Factors of Poor Hand and Oral Hygiene Practices Among Adolescent Students in Eastern China: A Cross-Sectional Study.

Purpose: This study aimed to investigate the current status and associated factors of hand and oral hygiene behaviors among adolescent students in Zhejiang Province, Eastern China.

Methods: This study utilized a cross-sectional survey conducted in Zhejiang Province between April and June 2022. Data were collected through a self-administered, structured questionnaire that assessed tooth brushing frequency, hand washing practices before meals, after toilet use, and hand washing with soap.

The Association Between the Triglyceride-Glucose Index, Its Combination with the Body Roundness Index, and Chronic Kidney Disease in Patients with Type 2 Diabetes in Eastern China: A Preliminary Study.

Objectives: This study aimed to investigate the relationship between the triglyceride-glucose (TyG) index, its combination with the body roundness index (BRI), and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) based on a cross-sectional analysis conducted in Eastern China.

Methods: The research originates from a cross-sectional study performed in Zhejiang Province, Eastern China, between March and November 2018. The TyG-BRI index was calculated based on triglyceride, fasting blood glucose, and the BRI.

Determining the status of small dense low-density lipoprotein cholesterol level in women undergoing menopausal transition.

Objective: Research on small dense low-density lipoprotein cholesterol (sdLDL-C) and menopausal status remains scarce. Our aim is to evaluate the relationship between serum sdLDL-C level and different menopausal status in a Chinese women population.

Methods: In 2022, a cross-sectional study was conducted including electronic standardized questionnaire surveys, anthropometric measurements, and biological specimen examinations based on communities.

The effect of hyperuricemia and its interaction with hypertension towards chronic kidney disease in patients with type 2 diabetes: evidence from a cross- sectional study in Eastern China.

Objectives: This study aimed to explore the synergistic interaction effect between hyperuricemia and hypertension towards chronic kidney disease in patients with type 2 diabetes.

Methods: This research originates from a cross-sectional study performed in Zhejiang Province, Eastern China, between March and November 2018. The correlation between serum uric acid levels and the risk of chronic kidney disease was assessed using a restricted cubic spline model.

Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults.

Objective: This study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults.

Methods: 13,500 participants from the Zhejiang Adult Chronic Disease Study were followed up between 2010 and 2021. A continuous MetS severity score derived from the five components of MetS was used to quantify MetS severity, and the association between MetS severity and the risk of incident CVD was assessed using Cox proportional hazard and restricted cubic spline regression.

Analysis of differential expression profile of miRNA in peripheral blood of patients with lung cancer.

Purpose: To identify potential molecular targets for lung cancer intervention and diagnosis, we analyzed the differential miRNA expression of peripheral blood between lung cancer patients and healthy controls.

Methods: Three pairs of cases' and controls' peripheral blood samples were evaluated for miRNA expression by microarray. 12 miRNAs were selected for RT-PCR validation and target genes prediction.

Gender disparity in the associations of overweight/obesity with occupational activity, transport to/from work, leisure-time physical activity, and leisure-time spent sitting in working adults: A cross-sectional study.

Background: The associations of occupational activity (OA), commuting, leisure-time physical activity (LTPA), and sitting with overweight/obesity in working adults are controversial. This study explored these factors with the risk of overall and abdominal overweight/obesity in a Chinese working population and whether these associations differ by gender.

Methods: A cross-sectional study was conducted.

[Joint association among physical activity, sedentary leisure time, job intensity, adiposity and the risks of diabetes in adult population of Zhejiang province].

Objective: To investigate the joint association of adiposity, physical activity, sedentary leisure time and job intensity on diabetes and impaired glycoregulation.

Methods: Data was from the 2010 Zhejiang survey and 17 437 adults ( ≥18 years) were examined. Logistic regression was used in this cross-sectional study.

Optimal cut-off points for two-step strategy in screening of undiagnosed diabetes: a population-based study in China.

To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated.

[Association between dyslipidemia and different subtypes of hypertension among Zhejiang population in 2010].

Objective: To explore the association between dyslipidemia and different subtypes of hypertension among Zhejiang population.

Methods: From June to October in 2010, 19 113 local residents aged ≥ 18 years old were selected among 7571 families from fifteen counties in Zhejiang by four stage stratified-random sampling method. A self-designed questionnaire was adopted to collect information on demographic characteristics, physical activity and life style.

[Prevalence and risk factors of pre-hypertension among adults of Zhejiang province].

Objective: To access the prevalence rates of pre-hypertensive patients at different stages and its associated risk factors among adults of Zhejiang province.

Methods: Study subjects were selected among local residents aged ≥ 18 years from 15 counties by multi stage stratified cluster random sampling method, from July to November, 2010. Each participant was required to complete questionnaire, physical examination and testing for overnight fasting blood specimen.

Association of combined maternal-fetal TNF-alpha gene G308A genotypes with preterm delivery: a gene-gene interaction study.

Preterm delivery (PTD) is a complicated perinatal adverse event. We were interested in association of G308A polymorphism in tumor necrosis factor-alpha (TNF-alpha) gene with PTD; so we conducted a genetic epidemiology study in Anqing City, Anhui Province, China. Case families and control families were all collected between July 1999 and June 2002.