Publications by authors named "Mingbao Xu"
Background Aims: Refractory B-cell lymphomas are difficult to successfully treat with current chemotherapeutic regimens; however, immunotherapy may be an effective form of treatment for these patients.
Methods: Fourteen refractory lymphoma patients (age, 29-74 y) were enrolled in the trial. α-1,3-galactosyl (α-Gal) epitopes were synthesized on lymphoma cell membranes with the use of bovine recombinant α-1,3-galactosyltransferase (α-GT) and neuraminidase to enhance tumor immunogenicity.
[Seroepidemiological survey of chickens infected with Toxoplasma gondii in Wuxi City].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
April 2012
Article Synopsis
- The study aimed to assess the prevalence of Toxoplasma gondii infections among scattered chickens in Wuxi City.
- A total of 309 scattered chickens were tested, showing a 22.33% overall positive infection rate, compared to only 2.67% in 150 intensive farming chickens, indicating a significant difference.
- The results suggest a high infection rate in scattered chickens, highlighting the need for increased attention from medical and veterinary professionals and food safety workers.
Aim: To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal epitope-pulsed dendritic cells (DCs) and cytokine-induced killer cells.
Methods: Freshly collected hepatocellular carcinoma (HCC) tumor tissues were incubated with a mixture of neuraminidase and recombinant α1,3-galactosyltransferase (α1,3GT) to synthesize α-Gal epitopes on carbohydrate chains of the glycoproteins of tumor membranes. The subsequent incubation of the processed membranes in the presence of human natural anti-Gal IgG resulted in the effective phagocytosis to the tumor membrane by DCs.