Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower.

Sclerotinia sclerotiorum as a necrotrophic fungus causes the devastating diseases in many important oilseed crops worldwide. The preferred strategy for controlling S. sclerotiorum is to develop resistant varieties, but the molecular mechanisms underlying S.

Associations between dietary coenzyme Q10 intake and lipid profiles in adults: a national cross-sectional study.

Objective: This study aimed to determine the average intake of CoQ10 from dietary sources and explore the dose-response relationships between the dietary-derived CoQ10 intake and lipid profiles.

Methods: We performed a cross-sectional study based on the China Health and Nutrition Survey, which included 7,938 adults. The dietary intake assessment used three consecutive 24-h recalls combined with a household inventory.

Design and synthesis of ()-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase.

The mitotic kinase Aurora A, a pivotal regulator of the cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery. However, the lack of specificity and potential toxicity have impeded clinical trials involving orthosteric inhibitors. In this study, allosteric sites of Aurora A were predicted using the AlloReverse web server.

The impact of environmental tournament on CO emissions from the perspective of synergizing the reduction of pollution and carbon emissions.

Synergizing the reduction of pollution and carbon emissions is the essential way for the construction of ecological civilization in the new era. Based on the panel data of 278 Chinese cities from 2006 to 2020, we study the effect of environmental tournament on carbon dioxide (CO) emissions. The results show that environmental tournaments have both effectiveness and limitations.

Functional Metallocenes as Cofactors Promote the Catalytic Performance of Mimetic Enzymes.

Coenzymes (cofactors) are essential for bio-redox reactions, group transfer reactions, and heterogeneous reactions of bio-enzymes, as well as the auxiliary transfer of electrons or atoms to promote bio-enzyme activity. However, when mimetic enzymes are scaled to the micro or nanoscale levels, both the absence of cofactor activity and the presence of migrating internal atoms cause self-depletion, eventually limiting sustained usage. Herein, cofactor regulation, a key issue long neglected in traditional mimetic enzyme construction is addressed.

A Novel Biosynthetic Strategy for Ginsenoside Ro: Construction of a Metabolically Engineered Strain Using a Newly Identified UGAT Gene from as the Key Enzyme Gene and Optimization of Fermentation Conditions.

Ginsenoside Ro, as one of the few oleanane-type ginsenosides, is well known for its unique molecular structure and biological activities. Currently, research on the biosynthesis of ginsenoside Ro is still in its early stages. Therefore, the establishment of a new ginsenoside Ro cell factory is of great significance for the in-depth development and utilization of genes related to ginsenoside Ro synthesis, as well as for the exploration of pathways to obtain ginsenoside Ro.

Regulation of ginseng adventitious root growth in Panax ginseng by the miR156-targeted PgSPL24-09 transcription factors.

MicroRNA (miRNA) is a class of non-coding endogenous small-molecule, single-stranded RNAs, and it is involved in post-transcriptional gene expression regulation in plants and plays an important role in plant growth and development. Among them, miRNA156 regulates members of target SPL gene family and thus participates in plant growth and development, hormonal response and adversity stress. However, it has not been reported in ginseng.

Identification of Gene for Ginsenoside Rg1 Biosynthesis as Revealed by Combining Genome-Wide Association Study and Gene Co-Expression Network Analysis of Jilin Ginseng Core Collection.

Ginseng, an important medicinal plant, is characterized by its main active component, ginsenosides. Among more than 40 ginsenosides, Rg1 is one of the ginsenosides used for measuring the quality of ginseng. Therefore, the identification and characterization of genes for Rg1 biosynthesis are important to elucidate the molecular basis of Rg1 biosynthesis.

Functional Validation of the Cytochrome P450 Family Gene in .

Ginseng ( C. A. Meyer) is an ancient and valuable Chinese herbal medicine, and ginsenoside, as the main active ingredient of ginseng, has received wide attention because of its various pharmacological active effects.

Efficacy of using telecare services for community-dwelling people with diabetes: A systematic review and meta-analysis.

Objective: To evaluate the glycated hemoglobin (HbA1c), blood pressure, self-efficacy, and quality of life efficacy of using telecare services for community-dwelling people with diabetes.

Methods: Cochrane Library, Web of Science, PsycINFO, PubMed, EMBASE, CINAHL, and Scopus databases were systematically searched from their inception dates to June 22, 2023. Two evaluators independently selected and evaluated eligible studies.

Genome-wide identification and integrated analysis of the FAR1/FHY3 gene family and genes expression analysis under methyl jasmonate treatment in Panax ginseng C. A. Mey.

Ginseng (Panax ginseng C. A. Mey.

Dual-Aptamer Recognition of DNA Logic Gate Sensor-Based Specific Exosomal Proteins for Ovarian Cancer Diagnosis.

Clinical diagnosis of ovarian cancer lacks high accuracy due to the weak selection of specific biomarkers along with the circumstance biomarkers localization. Clustering analysis of proteins transported on exosomes enables a more precise screening of effective biomarkers. Herein, through bioinformatics analysis of ovarian cancer and exosome proteomes, two coexpressed proteins, EpCAM and CD24, specifically enriched, were identified, together with the development of an as-derived dual-aptamer targeted exosome-based strategy for ovarian cancer screening.

The AP2/ERF Transcription Factor PgERF120 Regulates Ginsenoside Biosynthesis in Ginseng.

Ginseng ( C.A. Meyer) is a perennial herb belonging to the family and has been used for thousands of years in East Asia as an essential traditional medicine with a wide range of pharmacological activities of its main active ingredient, ginsenosides.

The effectiveness of brief reminiscence-based psychosocial interventions for cancer patients: A systematic review and meta-analysis.

Aim: To determine the effectiveness of brief reminiscence-based psychosocial interventions in alleviating psychological distress in cancer patients.

Background: Cancer patients suffer tremendous psycho-spiritual pain, which affects their quality of life. Brief reminiscence-based psychosocial interventions have demonstrated positive effects on the mental health of cancer patients; however, the efficacy of these interventions has been inconsistent.

Transcriptome-Wide Identification and Integrated Analysis of a Gene Involved in Ginsenoside Ro Biosynthesis in .

as a traditional medicinal plant with a long history of medicinal use. Ginsenoside Ro is the only oleanane-type ginsenoside in ginseng, and has various pharmacological activities, including anti-inflammatory, detoxification, and antithrombotic activities. UDP-dependent glycosyltransferase (UGT) plays a key role in the synthesis of ginsenoside, and the excavation of UGT genes involved in the biosynthesis of ginsenoside Ro has great significance in enriching ginsenoside genetic resources and further revealing the synthesis mechanism of ginsenoside.

Inverse Association between the Global Diet Quality Score and New-Onset Hypertension in Adults: A Nationwide Cohort Study.

Background: The Global Diet Quality Score (GDQS) is a simple and practical dietary metric associated with a number of chronic diseases. The GDQS included various foods related to blood pressure, especially diverse plant-based foods that have shown to lower blood pressure. However, studies on the role of the GDQS in reducing the risk of new-onset hypertension and whether its performance differs from that of other dietary metrics are lacking.

Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective.

Due to nonspecific pathological changes and the rapid degradation of insulin in postmortem blood samples, the identification of the cause of death during insulin overdose has always been a difficulty in forensic medicine. At present, there is a lack of studies on the toxicological changes and related mechanisms of an insulin overdose, and the specific molecular markers of insulin overdose are still unclear. In this study, an animal model of insulin overdose was established, and 24 SD rats were randomly divided into a control group, insulin overdose group, and a recovery group ( = 8).

ASD2023: towards the integrating landscapes of allosteric knowledgebase.

Allosteric regulation, induced by perturbations at an allosteric site topographically distinct from the orthosteric site, is one of the most direct and efficient ways to fine-tune macromolecular function. The Allosteric Database (ASD; accessible online at http://mdl.shsmu.

L-shaped association between dietary coenzyme Q10 intake and high-sensitivity C-reactive protein in Chinese adults: a national cross-sectional study.

: Chronic inflammation contributes to the occurrence and progression of many diseases. Most previous clinical studies have explored the effect of high-dose CoQ10 supplements on inflammation. Food is another important source of CoQ10, but the relationship between the intake of CoQ10 from dietary sources and inflammation was unknown.

An amorphous Ni-Fe catalyst for electrocatalytic dehydrogenation of alcohols to value-added chemicals.

As for the hydrogen production process electrocatalytic water splitting, the green and sustainable electro-oxidation of organic molecules at the anode is thermodynamically more favourable than the oxygen evolution reaction (OER). Here, we proposed for the first time to replace the OER process by the oxidation of N-Boc-4-piperidine methanol (BPM), a parallel reaction, which finally leads to the green production of N-Boc-4-piperidine carboxaldehyde (BPC). The amorphous NiFeO(OH) nanospheres with rich valence states were adopted as the anode catalyst, with creation of more active sites.

New urbanization and carbon emissions intensity reduction: Mechanisms and spatial spillover effects.

The advancement of new urbanization policy (NU) and the attainment of double carbon targets play pivotal roles in facilitating high-quality economic development in China. This paper conducts a comprehensive analysis of the mechanism and spatial spillover effects of NU on carbon emission intensity reduction (CEIR), building upon an examination of the nature of NU and the principles of urban carbon pollution control. The research employs a multi-period difference-in-difference model (DID) to explore the causal relationship between NU and CEIR, using panel data from 278 prefecture-level cities spanning the period of 2006 to 2020.