Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair.

With the growing interest in skeletal muscle diseases, understanding the processes, factors, and treatments associated with muscle regeneration is crucial. Skeletal muscle regeneration is a complex process that largely depends on the niche composed of cell populations, such as satellite cells, and their microenvironment. Cellular senescence is associated with various physiological processes and age-related diseases and plays a significant role in the muscle regeneration niche.

mutation regulated avian pathogenic pathogenicity though stress-resistance pathway.

gene mutation decreased the pathogenicity of the avian pathogenic strain, AE17. However, the associated regulatory mechanism of remains unknown. In this study, we examined the bactericidal activity of chicken serum and blood, as well as bacterial survival in HD11 macrophages.

[Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome].

Objective: Angiotensin-converting enzyme 2 (ACE2) gene polymorphisms have been shown to be implicated in hypertension, diabetic nephropathy, and other diseases. However, it remains unclear whether ACE2 gene polymorphisms are involved in the development of primary nephrotic syndrome (PNS) in children. The aim of this study was to assess the association between A9570G polymorphisms of ACE2 gene and PNS in a group of Han children in Guangdong Province, China.