Objectives: Resistance to apoptosis in esophageal squamous cell carcinoma (ESCC) constitutes a significant impediment to treatment efficacy. Exploring alternative cell death pathways and their regulatory factors beyond apoptosis is crucial for overcoming drug resistance and enhancing therapeutic outcomes in ESCC.
Methods: Mammalian Ste 20-like kinase 1 (MST1) is implicated in regulating various cell deaths, including apoptosis, autophagy, and pyroptosis.
The purpose of this study was to compare the predictive value of different lymph node staging systems and to develop an optimal prognostic nomogram for predicting distant metastasis in pancreatic ductal adenocarcinoma (PDAC). Our study involved 6364 patients selected from the Surveillance, Epidemiology, and End Results (SEER) database and 126 patients from China. Independent risk factors for distant metastasis were screened by univariate and multivariate logistic regression analyses, and a model-based comparison of different lymph node staging systems was conducted.
View Article and Find Full Text PDFOlanzapine is an antipsychotic drug applied in psychiatry to treat psychoses, especially schizophrenia and schizoaffective disorders with similar or better improvement than haloperidol and risperidone in the treatment of depressive and negative symptoms. The effect of olanzapine on neural synchrony remains to be explored. We investigated the effects of olanzapine on gamma oscillations in the CA3 region of the hippocampus and frontal association cortex.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantages of high stability, low immunogenicity, good biocompatibility, long circulation time and homing characteristics. Furthermore, the artificial modification of MSC-exosomes could amplify their advantages and their inhibitory effect on tumors and could overcome the limit of tumor-promoting effect.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma carries a poor prognosis and poses a serious threat to global health. Currently, there are few potential prognostic biomarkers available for the prognosis of hepatocellular carcinoma.
Methods: This pilot study used 4D label-free quantitative proteomics to compare the proteomes of hepatocellular carcinoma and adjacent non-tumor tissue.
Biochem Biophys Res Commun
November 2023
RPL27 is linked to the development of various diseases including malignant tumors. RPL27 may play an oncogenic function in hepatocellular carcinoma (HCC), but this is unknown. So, the aim of this study was to investigate how the human liver cancer cell lines SNU449 and HepG2 responded to RPL27 knockdown in terms of proliferation and apoptosis.
View Article and Find Full Text PDFOrganophosphorus insecticides (OPs), acting as serine phosphorylating agents in acetylcholinesterase (AChE), are highly effective neurotoxic insecticides. In our previous research, we found that six herbivorous pests and four ladybirds howed significantly higher AChE LC50 values than seven parasitoids and a predator (), and that there was a significant correlation with the corresponding bimolecular rate constant (Ki) value. The Ki value of pests was much smaller than that of natural enemies and had a higher LC50 value.
View Article and Find Full Text PDFPlant-derived exosome-like nanovesicles play an important role in transferring their biological cargos to recipient cells. The effect of garlic-derived exosome-like nanovesicles (GENs) against inflammatory bowel disease (IBD) remains unknown. This study aimed to investigate the effect of GENs on dextran sulphate sodium (DSS)-induced colitis in mice.
View Article and Find Full Text PDFNeuropathic pain is a refractory disease with limited treatment options due to its complex mechanisms. Whereas erythropoietin-producing hepatocyte A1 (EphA1) mediates the production of inflammatory factors that are important in the progression of neurological diseases, its role and molecular mechanisms in neuropathic pain remain unclear. In the present study, we established a mouse model of chronic constriction injury (CCI).
View Article and Find Full Text PDFSpontaneous imbibition of surfactants could efficiently enhance oil recovery in low permeability sandstone reservoirs. The majority of studies have considered the application of individual surfactants to alter wettability and reduce interfacial tension (IFT). However, a significant synergistic effect has been reported between different types of surfactants and between salts and surfactants.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
April 2023
Trophic dynamics is one of the major regulators of fishery production in marine ecosystems, which is important for the implementation of ecosystem-based fisheries management. Based on data collected form bottom trawl surveys in Haizhou Bay and adjacent waters during autumn of 2011 and 2018, Delta-GAMMs (Delta-generalized additive mixed models) were constructed to evaluate the effects of biotic and abiotic factors on the predation of five key prey species (including , , spp., , and ) in the Haizhou Bay.
View Article and Find Full Text PDFAnthocyanin accumulations in the flowers can improve seed production of hybrid lines, and produce higher commodity value in cotton fibre. However, the genetic mechanism underlying the anthocyanin pigmentation in cotton petals is poorly understood. Here, we showed that the red petal phenotype was introgressed from Gossypium bickii through recombination with the segment containing the R region in the A07 chromosome of Gossypium hirsutum variety LR compared with the near-isogenic line of LW with white flower petals.
View Article and Find Full Text PDFIn order to broaden the application of clean fracturing fluid in ultra-high temperature reservoirs, a surfactant gel for high-temperature-resistant clean fracturing fluid was developed with a gemini cationic surfactant as the main agent in this work. As the fracturing fluid, the rheological property, temperature resistance, gel-breaking property, filtration property, shear recovery performance and core damage property of surfactant gel were systematically studied and evaluated. Results showed the viscosity of the system remained at 25.
View Article and Find Full Text PDFIntroduction: Spinal cord injury causes permanent neurological deficits, which have devastating physical, social, and vocational consequences for patients and their families. Traditional Chinese medicine uses acupuncture to treat neuropathic pain and improve nerve conduction velocity. This treatment can also reduce peripheral nerve injury joint contracture and muscle atrophy in affected patients.
View Article and Find Full Text PDF5-HT receptors (5-HTRs) are widely expressed in the central nervous system, including in the ventrolateral orbital cortex (VLO). The VLO is an important cortical component for pain processing. Brain 5-HTRs are implicated in both pro- and anti- nociceptive functions.
View Article and Find Full Text PDFMonocytes/macrophages, a plastic and heterogeneous cell population of the tumor microenvironment (TME), can constitute a major component of most solid tumors. Under the pressure of rapid proliferation of the tumor, monocytes/macrophages can be educated and foster immune tolerance via metabolic reprogramming. Our studies have shown that the activation of FABP5, a lipid-binding protein, decreases the rate of β-oxidation causing the accumulation of lipid droplets in monocytes.
View Article and Find Full Text PDFThe internal coupled electromagnetic melt treatment (ICEMT) method is firstly proposed to produce high-quality and large-sized aluminum alloy billets. A three-dimensional model was established to describe the ICEMT process of direct chill casting (DC casting). The effect of ICEMT on the fluid flow patterns and temperature field in the DC casting of ϕ880 mm AA2219 billets is numerically analyzed.
View Article and Find Full Text PDFDue to the emergence of traditional drug resistance in tumor treatment, the anti-cancer therapies are facing multiple challenges. Immunotherapy, as a new and universal treatment, has been gradually concerned. The macrophages, as an important part of the immune system, play an important role in it.
View Article and Find Full Text PDFThe RNA modification N-methyladenosine (mA) has critical roles in many biological processes. However, the function of mA in the early phase of mammalian development remains poorly understood. Here we show that the mA reader YT521-B homology-domain-containing protein 1 (YTHDC1) is required for the maintenance of mouse embryonic stem (ES) cells in an mA-dependent manner, and that its deletion initiates cellular reprogramming to a 2C-like state.
View Article and Find Full Text PDFN-methyladenosine (mA), the most abundant reversible modification on eukaryote messenger RNA, is recognized by a series of readers, including the YT521-B homology domain family (YTHDF) proteins, which are coupled to perform physiological functions. Here, we report that YTHDF2 and YTHDF3, but not YTHDF1, are required for reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). Mechanistically, we found that YTHDF3 recruits the PAN2-PAN3 deadenylase complex and conduces to reprogramming by promoting mRNA clearance of somatic genes, including Tead2 and Tgfb1, which parallels the activity of the YTHDF2-CCR4-NOT deadenylase complex.
View Article and Find Full Text PDFWe present an injection-seeding -switched 1645 nm Er:YAG ceramic laser with high frequency stability and energy stability by combining the injection-seeding technique and Pound-Drever-Hall technique. 10.31 mJ single-frequency pulses with optimal frequency stability (525 kHz) and relative energy stability (0.
View Article and Find Full Text PDFA 4-pass structure Er:YAG MOPA system at 1645 nm is theoretically and experimentally investigated. In accordance with the theoretical analysis, the 4-pass structure significantly improved the amplification performance. The highest gain is about 4 with 1 mJ incident seed energy.
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