Publications by authors named "MingTong Hou"
Septic cardiomyopathy (SCM) represents a key feature of sepsis-associated cardiovascular failure, and ferroptosis is one of the essential causes of septic cardiac dysfunction. In this study, combined with omics analysis and in vivo experiments, we verified the damage of ferroptosis on cardiac tissue in septic mice and mined the target genes that can inhibit ferroptosis in cardiomyocytes. Lipocalin-2 (Lcn2) was identified to be associated with SCM progression via integrated transcriptomic and proteomic analyses.
View Article and Find Full Text PDFSalidroside attenuates sepsis-induced acute lung injury by inhibiting ferroptosis-dependent pathway.
Korean J Physiol Pharmacol
November 2024
Article Synopsis
- Sepsis can lead to acute lung injury (ALI) due to a strong inflammatory response, and salidroside (SAL) is known for its anti-inflammatory and antioxidant effects.
- The study investigated how SAL affects ALI in a septic mouse model, analyzing lung tissue damage, inflammatory factors, and the ferroptosis pathway.
- Results showed that SAL treatment improved lung tissue health, reduced harmful inflammatory markers, and inhibited ferroptosis, indicating its potential as a therapeutic option for sepsis-induced ALI.