Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice.

The adenosine triphosphate-binding cassette transporter A7 (ABCA7) gene is ranked as one of the top susceptibility loci for Alzheimer's disease (AD). While ABCA7 mediates lipid transport across cellular membranes, ABCA7 loss of function has been shown to exacerbate amyloid-β (Aβ) pathology and compromise microglial function. Our family-based study uncovered an extremely rare ABCA7 p.

Genome sequence of , identified in the United States.

is a parvovirus that was identified in the blood of four horses in the United States. Here, we report one genome from a horse in New York State. This genome may represent a new species within the genus .

Right versus left thoracic approach esophagectomy for patients with neoadjuvant immunochemotherapy.

Background: The purpose of this study was to investigate the safety and efficacy of left thoracic approach (LTA) and right thoracic approach (RTA) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant immunochemotherapy (NICT).

Methods: This study included 83 ESCC patients who underwent right transthoracic esophagectomy ( = 61) and left transthoracic esophagectomy ( = 22) after NICT in our hospital from October 2019 to September 2023. The data of these patients were retrospectively analyzed.

Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation.

Background: There is higher prevalence of chronic kidney disease (CKD) in burn patients after hospital discharge; however, the cause remains unclear. This study aimed to investigate the lasting impacts of severe burns on the kidneys and to explore potential treatments.

Methods: The study examined the effects of burning on healthy mice and adenine-induced CKD mice.

Boy's love fans versus non-fans in the sexual identity and neural response in the digital age's young females.

With the omnipresence of online social media, Boys' Love (BL) culture has found a burgeoning audience among young females. However, we know very little about the audience of this online cultural phenomena, also the potential implications of BL culture to female remain under-explored. Study 1 conducted a survey to investigate the BL audience's demography data and attitudes to homosexual ect.

Biomimetic Nanostructure Engineering of Ultralow Ir-Loading Electrocatalysts for Oxygen Reduction Reaction.

Promoting the rate of the oxygen reduction reaction (ORR) is critical for boosting the overall energy efficiency of the flexible zinc-air batteries (FZABs). Inspired by nature, we designed "branch-leaf" like hierarchical porous carbon nanofibers with ultralow loadings of Ir nanoparticles (NPs) derived from covalent-organic framework/metal-organic framework (COF/MOF) core-shell hybrids. The as-obtained Ir/FeZn-hierarchical porous carbon nanofibers (HPCNFs) showcase enhanced ORR performance, and the ultralow Ir loading reduces the cost while maintaining catalytic capacity.

Causal Relationship Between Autoimmune Rheumatic Diseases and Iridocyclitis: A Bidirectional Two-Sample Mendelian Randomization Study.

Purpose: This study aims to explore the relationship between autoimmune rheumatic diseases (ARDs) and the risk of iridocyclitis (IC) using Mendelian randomization (MR) analysis.

Methods: Data of ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis (JIA), Behcet's disease (BD), and iridocyclitis were obtained from genome-wide association studies with large sample sizes. The instrumental variable utilized in this study for each exposure was the single nucleotide polymorphism.

O-GlcNAcylation of DJ-1 suppresses ferroptosis in renal cell carcinoma by affecting the transsulfuration pathway.

Renal cell carcinoma (RCC) is one of the most common urological malignancies worldwide, and advanced patients often face challenges with chemotherapy resistance and poor prognosis. Ferroptosis, a novel form of cell death, offers potential therapeutic prospects. In this study, we found that DJ-1 was elevated in kidney renal clear cell carcinoma (KIRC), and this abnormal expression pattern was closely associated with clinical pathological characteristics and worse prognosis.

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control.

Quality control (QC) in mass spectrometry (MS)-based proteomics is mainly based on data-dependent acquisition (DDA) analysis of standard samples. Here, we collect 2754 files acquired by data independent acquisition (DIA) and paired 2638 DDA files from mouse liver digests using 21 mass spectrometers across nine laboratories over 31 months. Our data demonstrate that DIA-based LC-MS/MS-related consensus QC metrics exhibit higher sensitivity compared to DDA-based QC metrics in detecting changes in LC-MS status.

Computer-assisted enzyme cocktails enhance fermentation by overcoming toxic inhibitors from pretreatment processes.

Lignocellulosic biomass is the most abundant form of biomass available for fuel production, serving as the fourth leading energy source globally. However, inhibitors generated during pretreatment processes often hinder fermentation performance and conversion efficiency. In this study, we developed an enhanced computer-assisted enzyme cocktail strategy (ComEC 2.

Relational Victimization, Coping Styles and Depressive Symptoms: A Test of Bidirectional Associations in Adolescence.

Although evidence from previous studies suggests that adolescents with negative coping styles who experienced victimization are more likely to exhibit depressive symptoms, these associations have not yet been disentangled to separate between-person differences from within-person effects. To investigate the within-person bidirectional relationships among relational victimization, coping styles and depressive symptoms, this study conducted a four-wave random intercept cross-lagged panel model analysis. The final sample consisted of 1506 adolescents, 72.

Integrated RNA sequencing analysis and machine learning identifies a metabolism-related prognostic signature in clear cell renal cell carcinoma.

The connection between metabolic reprogramming and tumor progression has been demonstrated in an increasing number of researches. However, further research is required to identify how metabolic reprogramming affects interpatient heterogeneity and prognosis in clear cell renal cell carcinoma (ccRCC). In this work, single-cell RNA sequencing (scRNA-seq) based deconvolution was utilized to create a malignant cell hierarchy with metabolic differences and to investigate the relationship between metabolic biomarkers and prognosis.

Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer's disease.

Background: Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by an aging population. Although the plethora of hypotheses are proposed to elucidate the underlying mechanisms of AD, from amyloid-beta (Aβ) accumulation and Tau protein aggregation to neuroinflammation, a comprehensive understanding of its pathogenesis remains elusive. Recent research has highlighted the critical role of calcium (Ca) signaling pathway in the progression of AD, indicating a complex interplay between Ca dysregulation and various pathological processes.

[The Preservation of HBV, HCV, HIV Viral Nucleic Acids in Plasma by Dry Spot Method and the Duration of Preservation].

Objective: To establish a method for preserving viral nucleic acids in plasma using a blood collection card based on the dry spot method, to predict the duration of nucleic acid preservation by establishing the Arrhenius equation, and to demonstrate the feasibility of this preservation method for the re-testing of nucleic acids in blood samples retained by blood banks.

Methods: Plasma samples positive for HBV, HCV, and HIV nucleic acids were prepared into preservation cards in the form of dry plasma spots for storage. The prepared preservation cards were placed under accelerated storage conditions at 37, 45, 50, and 55 ℃.

Design of semi-open prosthetic socket with constant force for lower limb.

Background: Prosthetic socket is a key component of the prosthesis for clinical application; its performance directly affects the adaptation of the residual limb to the prosthetic socket. There are long-term and short-term volume fluctuation of the residual limb. The volume fluctuation of the residual limb will lead to the pressure mismatch at the interface of the residual limb and the prosthetic socket, which will cause a series of skin and fit problems.

Dynamic Mechanical Properties and Damage Morphology Analysis of Concrete with Different Aggregates Based on FDM-DEM Coupling.

To study the dynamic compressive mechanical properties of concrete with different aggregates (limonite and lead-zinc ore), a dynamic mechanical experiment was carried out by the Φ 100 mm SHPB equipment. Based on the coupling of the finite difference method (FDM) and the discrete element method (DEM), a three-dimensional numerical model was constructed. The effects of various strain rates and aggregate types on the dynamic mechanical properties of concrete, the dynamic increase factor (DIF), and the dynamic impact damage process were analyzed and discussed.

The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer's Disease at the Single Cell Level.

Alzheimer's disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients are females. Basic and clinical research studies show evidence supporting sex-specific differences contributing to the complexity of AD. There is also strong evidence supporting sex-specific interaction between the primary genetic risk factor of AD, and AD-associated neurodegenerative processes.

Research on a novel flexible bionic artificial anal sphincter.

Background: Artificial anal sphincter is a novel method for the treatment of fecal incontinence. Aiming at the problems of complex mechanical structure, high mechanical failure rate, large volume and poor biocompatibility of existing artificial anal sphincters, this article proposes a novel flexible artificial anal sphincter with bionic structure.

Methods: A novel flexible artificial anal sphincter was proposed with bionic structure by analogy with the puborectalis, flexible transmission by flexible tendons, good biocompatibility by using thermoplastic urethane and medical silicone, small size and lightweight.

Analysis of cis-regulatory changes underlying phenotype divergence shaped by domestication in pigs.

Background: Cis-regulatory elements (CREs) are regions of DNA that regulate the expression of nearby genes. Changes in these elements can lead to phenotypic variations and adaptations in different populations. However, the regulatory dynamics underlying the local adaptation of traits remain poorly understood in Chinese and Western pigs.

Bibliometric analysis of microphthalmos and anophthalmos over 20 years: from 2004 to 2023.

Aim: To conduct a bibliometric analysis of studies on microphthalmos and anophthalmos (M/A), explore research hotspots, and provide information on future research interests in this field to benefit clinicians and researchers.

Methods: Totally 751 publications related to M/A from the year 2004 to 2023 were collected from the Web of Science Core Collection database. These publications consist of both original and review articles, that are composed in English.

The enhancement of immunoactivity induced by immunogenic cell death through serine/threonine kinase 10 inhibition: a potential therapeutic strategy.

Introduction: Immunogenic cell death (ICD) is capable of activating the anti-tumor immune response of the organism; however, it is concurrently a complex process involving multiple factors. The specific factors that impact the occurrence of ICD remain undefined.

Methods: Through cluster analysis, patient specimens retrieved from the TARGET, TCGA, and GEO AML databases were categorized into two subtypes based on the expression levels of ICD-related genes: ICD-high and ICD-low.

Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity.

Introduction: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within non-Hispanic White (NHW) populations. Here we provide an extensive survey of the proteomic landscape of AD across diverse racial/ethnic groups.

Methods: Two cortical regions, from multiple centers, were harmonized by uniform neuropathological diagnosis.