Publications by authors named "Ming-xu Da"
Purpose: Gastric cancer is the most common malignancy worldwide and is the third leading cause of cancer-related deaths, urgently requiring an early and non-invasive diagnosis. Circulating extracellular vesicles may emerge as promising biomarkers for the rapid diagnosis in a non-invasive manner.
Methods: Using high-throughput small RNA sequencing, we profiled the small RNA population of serum-derived extracellular vesicles from healthy controls and gastric cancer patients.
Article Synopsis
- The study aims to create an AI-based model to predict the progression of castration-resistant prostate cancer (CRPC) using data from multiparametric MRI and histopathology, which could help improve patient prognosis.
- Researchers collected data from 399 prostate cancer patients and used deep learning techniques on MRI images and pathology slides to develop and assess the predictive model's performance.
- The final combined model achieved an AUC of 0.86, demonstrating good predictive accuracy and potential clinical benefits in guiding treatment decisions for patients at risk of CRPC.
By the year 2035 more than 4 billion people might be affected by obesity and being overweight. Adipocyte-derived Extracellular Vesicles (ADEVs/ADEV-singular) are essential for communication between the tumor microenvironment (TME) and obesity, emerging as a prominent mechanism of tumor progression. Adipose tissue (AT) becomes hypertrophic and hyperplastic in an obese state resulting in insulin resistance in the body.
View Article and Find Full Text PDFExpression and Clinical Significance of in Gastric Cancer.
Comb Chem High Throughput Screen
June 2023
Article Synopsis
- - The research aimed to analyze the expression and clinical importance of a specific protein (denoted as " ") in gastric cancer (GC).
- - Immunohistochemistry was used to compare protein levels in GC tissues versus normal tissues, finding lower levels in cancer samples and correlations with tumor metastasis and stage.
- - The study suggests that this protein is a potential target for early diagnosis and prognosis in gastric cancer patients, with several interacting proteins identified that may also be relevant.
Background: Pyogenic liver abscesses are insidious in the early stage. Some cases progress rapidly, and the patient's condition can worsen and even become life-threatening if timely treatment is not provided. Surgery and prolonged antibiotic treatment are often required if the abscess is large and liquefied and becomes separated within the lumen.
View Article and Find Full Text PDFArticle Synopsis
- Distal pancreatectomy with En-bloc celiac axis resection (DP-CAR) is a complex surgical procedure used to treat advanced pancreatic cancer, particularly when there is tumor invasion of nearby blood vessels.
- A systematic review of 11 high-quality studies (involving 1072 patients) found that DP-CAR has a lower rate of complete tumor removal (R0 resection) and three-year survival compared to standard distal pancreatectomy (DP), along with higher postoperative mortality and longer surgery and hospital stay times.
- Despite its drawbacks, DP-CAR may provide better survival and quality of life than palliative treatments, suggesting it could be considered for patients who can handle the significant perioperative risks involved.
[S-Adenosylmethionine Inhibits Expression of Vascular Endothelial Growth Factor-C Protein and Cellular Proliferation in Gastric Cancer].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2015
Article Synopsis
- - The study investigates how S-adenosylmethionine (SAM) affects the growth of gastric cancer by altering the methylation of the VEGF-C gene promoter.
- - Researchers used MTT analyses and a nude mouse model to show that SAM significantly increases the methylation of the VEGF-C promoter, leading to decreased protein levels of VEGF-C, which is linked to cancer growth.
- - The findings suggest that SAM can reverse DNA hypomethylation of VEGF-C, effectively inhibiting gastric cancer growth both in lab experiments and in live subjects.
Recent studies have revealed that malignant tumors can actively induce the formation of new lymphatic vessels and metastasize through the lymphatic system. Tumor-induced lymphangiogenesis driven by tumors expressed lymphangiogenic growth factors such as VEGF family, fibroblast growth factor 2 (FGF-2), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and platelet-derived growth factors (PDGFs) is correlated with lymph node metastasis in experimental cancer models and in several types of human cancers. Tumor- induced lymphangiogenesis has now been firmly established as a novel mechanism for cancer progression and lymph node metastasis.
View Article and Find Full Text PDFBackground: Recent observations have suggested that overexpression of cyclooxygenase-2 (COX-2) promotes tumor lymphangiogenesis through an upregulation of vascular endothelial growth factor-C (VEGF-C) expression. It is unclear whether this mechanism also acts in gastric cancer. The aim of this study was to determine the relationship between COX-2 and VEGF-C expression in human gastric cancer, as well as to correlate with lymph node involvement, prognosis, and other clinicopathologic parameters.
View Article and Find Full Text PDFAim: To evaluate the efficacy of telomerase activity assay and peritoneal lavage cytology (PLC) examination in peritoneal lavage fluid for the prediction of peritoneal metastasis in gastric cancer patients, and to explore the relationship between telomerase activity and proliferating cell nuclear antigen expression.
Methods: Telomeric repeated amplification protocol (TRAP)-enzyme-linked immunosorbent assay (ELISA) was performed to measure the telomerase activity in 60 patients with gastric cancer and 50 with peptic ulcer. PLC analysis of the 60 patients with gastric cancer was used for comparison.
[Expression of galectin-3 mRNA in gastric cancer with peritoneal metastasis].
Sichuan Da Xue Xue Bao Yi Xue Ban
January 2006
Objective: To search for the role of galectin-3 gene in gastric cancer with peritoneal metastasis.
Methods: Using real-time quantitative RT-PCR for detecting the expression of galectin-3 mRNA in 35 matched samples, including primary cancer lesions, lymph node lesions, peritoneal metastasis and adjacent noncancerous mucosa. ANOVA and SNK-q test were used.
[Study on association between the expression of galectin- 3 and the peritoneal metastasis in gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
March 2005
Article Synopsis
- - The study aimed to explore the relationship between galectin-3 protein expression and peritoneal metastasis in gastric cancer patients.
- - Researchers analyzed tissue samples from 35 patients, finding that 97% of gastric cancer lesions showed high levels of galectin-3, while only 14% of normal tissues did.
- - The results suggest that galectin-3 could serve as a useful marker for identifying peritoneal metastasis in gastric cancer and may provide prognostic information prior to surgical intervention.
Objective: To detect the expression of IGFBP-2 mRNA in gastric cancer tissues and its roles in neoplasia and peritoneal metastasis of gastric cancer.
Methods: The IGFBP-2 mRNA expression levels in the fresh tissues from normal mucosa, primary cancer and peritoneal metastasis of 35 patients with gastric cancer were determined by the quantitative real time RT-PCR method, and the samples were sliced up and stained with hematoxylin-eosin for pathologyical examination.
Results: The levels of IGFBP-2 mRNA expression in gastric primary cancer tissues were significantly higher than those in the tissues from normal mucosa and peritoneal metastasis (P<0.